Robert C. Miller, M.D.

Closed for Enrollment

• A Prospective Radiogenomics Registry for Validating Predictive Models and Biomarkers of Radiotherapy Toxicity in the REQUITE Study Jacksonville, Fla.

  The purpose of this study is to help predict which patients are at greater risk for side effects from radiotherapy.

  Aims, purpose, or objectives:

  1. Establish a prospective cohort of 500 patients with breast, lung, and prostate cancer treated with external beam radiotherapy at Mayo Clinic Florida followed with standardized quality of life and toxicity assessments.
  2. Establish a registry of patient data and germline DNA samples for validation of models and biomarkers for early detection of risk of radiotherapy related side effects.
  3. The registry will establish a cohort of patients at May Clinic Florida that can be used as a resource for external partnerships in research.

   

• Phase III, Randomized, Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy Rochester, Minn., Scottsdale/Phoenix, Ariz.

   

  The purpose of this study of sulfasalazine is to see how well it works in preventing acute diarrhea in patients with cancer who are undergoing pelvic radiation therapy. Sulfasalazine may relieve diarrhea in patients with cancer who are undergoing pelvic radiation therapy.