Erik K. St Louis, M.D.

The purpose of this study is to follow patients with REM sleep behavior disorder (RBD) over time and learn which types of RBD patients may be at risk of developing other diseases.

The purpose of this study is to evaluate the use of a smartphone app for stroke patients with obstructive sleep apnea in order to better use their positive airway pressure (PAP) therapy.

This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD).

The purpose of this study is to examine the safety and effectiveness of suvorexant (MK-4305) to improve sleep in individuals who have Alzheimer's disease.

The purpose of this study is to provide access to treatment with pitolisant while a U.S. New Drug Application (NDA) is being prepared and submitted for review for marketing approval. This program will be open to adult patients in the U.S. with Excessive Daytime Sleepiness (EDS) associated with narcolepsy, with or without cataplexy. Pitolisant will be made available through treating physicians participating in the program.

Automobile driving is a crucial aspect of everyday life, but driving safety problems including car crashes or speeding violations are a serious public health problem. Alzheimer’s Disease (AD) affects the ability to safely drive and raises crash risk. Mild cognitive impairment (MCI) raises the risk of dementia, and people with MCI have been shown to have problems with memory, decision making, and the ability to concentrate that could lead to unsafe driving, even before obvious dementia begins. Whether MCI patients who continue to drive are safe drivers or not is unknown.

This study aims to obtain EEG data on individuals at all stages of AD from preclinical through severe dementia.

The purpose of this study is to measure electrophysiologic biosensor signals recorded from patients. We will measure electrophysiologic and biosensor signals in patients with neurological, psychiatric, sleep and medical disorders, and compare them to measurements in age- and sex-matched controls without these disorders, and analyze medical records  to determine possible demographic or clinical predictors for observed differences in signal characteristics between patients and controls. The goal is to define biosensor signal characteristics and alterations in human subjects and their associations with clinical characteristics and to explore changes in biosensor characteristics over time in selected individuals.

The purpose of this study is to determine the frequency of sleep behavior disorder by age group and sex in Olmsted County MN.