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  • Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH) (CASH-B) Rochester, Minn.

    The purpose of this study is to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.

Closed for Enrollment

  • Cavernous Malformation Prospective Registry (cav mal) Rochester, Minn.

    Investigators are trying to learn more about why cavernous malformations form. In addition, investigators are trying to determine which cavernous malformations might cause future symptoms and which ones may be more benign. To do this, investigators are trying to look at various lifestyle factors, medication use, and other medical problems and how they influence what happens over time
  • Identification of risk factors and risk markers in Patients with Cavernous Malformations Rochester, Minn.

    This study aums to determine whether various markers of vascular stability are predictive of clinical events (intracerebral hemorrhage or focal neurologic deficits). The study will alos determine the prevalence of vitamin D deficiency in patients with cavernous malformation and determine if vitamin D deficiency correlates with presenting classification (Hemorrhage, Focal Neurologic Deficit, Seizure, Asymptomatic state) or natural history (hemorrhage risk).
  • Multicenter Arteriovenous Malformation Research Study (MARS) of Outcomes Rochester, Minn.

    The purpose of this study is to identify robust, clinically-applicable risk factors for stroke and death in unruptured bAVMs, and study long-term outcomes in patients with and without treatment.
  • Natural History of Vertebrobasilar Non-Saccular and Dolichoectatic Aneurysms: A Retrospective Review and Prospective Cohort Study Rochester, Minn.

    The purpose of this study is to learn more about why and what influences these types of brain aneurysms to form, grow or rupture. We will be looking at factors such as medical problems, medications, lifestyle factors and how they may be a role.
  • The Natural History of Intracranial AVMs Rochester, Minn.

    The purpose of this study is to learn more about arteriovenous malformation (AVM), a type of blood vessel abnormality in the brain. 
  • Trial Readiness in Cavernous Angiomas with Symptomatic Hemorrhage (CASH) (CASH) Rochester, Minn.

    The purpose of this study is to set up the infrastructure for future clinical trials for patients with cavernous malformations. To do this we will be assessing the quality of MRI and data collection from patients with cavernous malformations across multiple sites in the country. At Mayo, we will be looking at new MRI "sequences" in addition to the usual sequences to see if that helps determine which cavernous malformations may bleed again.
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