Daniel B. F. Saris, M.D., Ph.D.

The purpose of this study is to administor Patient Reported Outcome questionnaires to patients with musculoskeletal conditions who are undergoing a surgical procedure at Mayo Clinic Orthopedic Surgery and Sports Medicine practice.

The purpose of this study is to evaluate the effectiveness of SoftStitch™ for All-Inside Meniscal Repair of longitudinal tears on the posterior horn, and to observe improvement for ePROM and functional assessments of the knee at 24 months follow-up when compared to baseline.

The secondary objective is to assess complications related to SoftStitch™, retears and repeated surgery. Structural healing of the meniscus will be evaluated at 6 months with MRI. Also, the safety profile of SoftStitch™ for All-Inside Meniscal Repair will be observed.

The objectives of this study are to produce an allogeneic cartilage bank whereby cartilage tissue is obtained from consented donors who meet 21 CFR 1271 donor eligibility criteria, and to simluate clinical implantation of living donor osteochondral allografts banked from Aim 1, demonstrated to meet both viability and sterility requirements, in patients undergoing osteochondral transplantation in the Mayo clinical practice. Actual grafting using collected cartilage will not occur. This is a process validation study.

The results of this study will optimize the care for patients with a meniscus root tear. Surgeons will be able to determine if MRR (meniscus root repair) with transtibial pullout technique is an effective treatment and will identify potential risk factors for poor clinical outcomes. In addition, investigators will determine if MRR is successful in delaying the radiographic progression of arthritis in the involved compartment.