Faculty

Jeffrey L. Winters, M.D.

Clinical Studies

Evaluating sPD-L1 Clearance in Patients Undergoing Plasma Exchange Therapy Rochester, Minn.
The purpose of this study is to establish the clearance rate of sPD-L1 in patients undergoing plasma exchange, and to establish the kinetics of sPD-L1 regeneration in vivo.

Evaluation of the AMICUS Extracorporeal Photopheresis (ECP) System using the phelix Irratiation Device in Patients with Chronic Graft Versus Host Disease (MVSS FRE006-17) Rochester, Minn.
The purpose of this study is to evaluate the inhibition of lymphocyte proliferation in ECP treated MNC samples obtained from cGVHD subjects treated with the AMICUS ECP System.
High Inlet Flow Rate Hematopoietic Progenitor Cell Collection Using the Fenwal Amicus Rochester, Minn.
The purpose of this study is to perform a paired comparison of CD34+ cell and lymphocyte yield, as well as cross-cellular contamination, on the same patient/donor using the 85 ml/min high flow rates versus the standard speeds of 65 ml/min for pre WBC of > 35 x109/L or 90 ml/min for pre WBC of ≤ 35 x109/L. Quantities of CD34+cells, lymphocytes, white blood cells, red blood cells, and platelets in the products would be compared. In addition, collection efficiency of CD34+ cells and lymphocytes would be compared. The yields and collection efficiencies would be used to judge the effect of the high flow rates.
Leukemic Cells Depletion (Leukapheresis) using Amicus Separator (Fresenius-Kabi) Rochester, Minn.

The purpose of this study is to determine if the device being used, the Amicus apheresis device, can perform effective leukapheresis procedures and be used instead of the COBE Spectra when it is no longer available.