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  • Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune Profiling Rochester, Minn.

    The purpose of this study is to provide novel information describing how immune responses to inactivated influenza A/H1N1 vaccine are generated. 
  • Development of a Peptide-Based SARS-CoV-2 Candidate Vaccine (SARS-CoV-2) Rochester, Minn.

    The purpose of this study is to identify SARS-CoV-2 peptides capable of being processed and presented by antigen presenting cells during viral infection, to test peptides for biologic/immunologic relevance in PBMCs from recovered COVID-19+ cases, and to perform in vivo infection studies in mice (ACE2 x HLA A2 transgenic) using individual peptide and/or peptide combinations with and without adjuvants to identify the optimal protective potential of the identified peptide/peptides against wild virus challenge.

     

     

     
  • Mayo Clinic COVID-19 Pandemic Response Biobank (Prospective) (NA) Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

    The purpose of this research repository is to prospectively collect research biospecimens and corresponding clinical and patient provided data from COVID-19 patients with confirmed infection with the novel SARS-CoV-2 virus to enable high quality research. 
  • Mayo Clinic COVID-19 Pandemic Response Biobank of Clinical Residual Samples Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

    The purpose of this study is to collect residual (waste) blood, urine, and stool specimens remaining from clinician order testing and corresponding clinical and patient provided data from COVID-19 patients with confirmed or suspected infection with the novel SARS-CoV-2 virus to enable high quality research. 

     
  • The Impact of Age on Vaccine-Induced Activation of Human Inflammasome Complexes and Adaptive Immunity against Influenza Virus Rochester, Minn.

    The purpose of this study is to examine the effects of aging on the innate immune system components controlling inflammation following influenza vaccination. We will also examine correlations between these early innate responses and the subsequent adaptive immune responses.
  • Transcriptomic Signatures of Influenza Vaccine Responses Rochester, Minn.

    The purpose of this research study is to better understand the immune response to the Adjuvanted Subunit flu vaccine (MF59) and the High Dose flu vaccine (HDFlu) in people 65 years of age and older.
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