Filter Results
Clinical Studies
Results filtered:Study status:
Closed for Enrollment
Closed for Enrollment
-
Assessment of Impulsivity and its Association with Post-Treatment Relapse in Subjects with Substance Use Disorders: A Feasibility Study
Rochester, Minn.
Impulsivity is a major component of addictive behavior contributing to the initiation and perpetuation of Substance Use Disorders (SUDs). The purpose of this study is to investigate the correlation of self-reported measures of impulsivity, neurocognitive task measures of impulsivity, with craving intensity, the correlation of neurocognitive task measures of impulsivity, and the association between impulsivity measures and sequence variability in the A2AR gene.
-
Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome
Rochester, Minn.,
Albert Lea, Minn.
The purpose of this project is to identify biomarkers by discovery of genomic and metabolomic markers associated with response to acamprosate treatment. To achieve this we will use “pharmacometabolomics-informed pharmacogenomics” such as generation a panel of iPSCs (stem cells) to discover biomarkers. A new prospective randomized placebo-controlled trial of 3 month long treatment with acamprosate/placebo will provide new biospecimens, in addition to previously collected biospecimens, to enable the search for genetic and metabolomic biomarkers associated with sobriety or relapse in participants of this new study.
.