Rafael J. Sierra, M.D.

The purpose of this study is to evaluate the safety and effectiveness of VT-X7. Also, to evaluate superiority at 365 days in a composite endpoint of Overall Success, overall safety of the VT-X7 procedure, quality of life (QoL), and patient survival. The exploratory objective is to compare Experimental and Control Arms in exploratory endpoints.

The purposes of this study is to isolate RNA from bone tissues from ONFH and osteoarthritis (OA) femoral heads and perform RNA sequencing to measure gene expression.

The purpose of this study is to improve the surgical treatment outcomes of femoroacetabular impingement (FAI), which is affecting an increasing number of military personnel and young active individuals in the general population. The proposed study will investigate critical patient, disease, and surgical treatment predictors of femoroacetabular impingement (FAI) surgery outcomes.

This study is designed to:
-analyze effects of surgical treatment
-improve surgical care and quality of life of patients with hip problems/diseases
-ID predictors of surgical outcomes to identify/improve future treatments
-Collect data, images, from patients undergoing surgical treatment of hip disorders (we will not be collecting social security numbers to send to Washington University).

The purpose of this study is to obtain prospective follow-up of a cohort of patients treated with an open surgical hip dislocation (OSHD) at Mayo Clinic from 1997-2018 and to report the long-term outcomes.  Specifically, we will assess the proportion of patients undergoing additional procedures to the affected hip, the proportion of patients satisfied with the procedure, the proportion of patients who would have the procedure again, the preoperative, postoperative, and current activity levels of the patient using a standardized questionnaire.

The purpose of this study is to ascertain which patients have undergone a revision PAO and to track their respective follow-ups.

The purpose of this study is to evaluate the complication risk and survivorship associated with shoulder and hip decompression surgeries. Identifying the incidence and nature of complications will provide insights into the risks associated with these procedures, while understanding survivorship trends will assess the long-term efficacy and durability of the surgeries. Understanding these factors is crucial for improving patient outcomes, refining surgical techniques, and informing preoperative counseling.

The purpose of this study is to provide access to the VT-X7 (Vancomycin, Tobramycin Exchanged in 7 Days) system for subjects with periprosthetic joint infection (PJI) of the hip or knee who lack therapeutic treatment alternatives.

The study will assess the outcomes of patients treated with concomitant hip arthroscopy at the time of periacetabular osteotomy (PAO) for patients with hip dysplasia compared with patients treated with PAO alone.

The purpose of this study is to assess perioperative and postoperative outcomes to date in patients treated with surgery (Periacetabular Osteotomy or PAO) for Developmental Dysplasia of the Hip (DDH) receiving formal postoperative physical therapy versus those patients who did not receive formal postoperative physical therapy.

The purpose of this study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty

The purpose of this study is to document the effects of clinical and/or x-ray abnormalities of the hip suggestive of femoroacetabular impingement (a structural deformity in the hip joint) of asymptomatic adolescents to see if they show progression of their first pathology findings on MRI, after 5 years of follow up.

The purpose of this study is to evaluate the correlation between a novel pelvic sensor that assesses spinopelvic motion with lateral sit-to-stand radiographs, and to evaluate the relationship between a novel pelvic sensor with pelvic tilt, sacral slope, and lumbar lordosis.

The purpose of this study is to determine the most efficient and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.

The purpose of this study is to determine if cells from a patient's own adipose tissue is safe and capable of helping regenerate the femoral head in patients with osteonecrosis. The standard of care is known as hip decompression which simply removes dead tissue from the femoral head and creates a new cavity to be filled in by healthy bone. This trial will use hip decompression plus saline injection in one hip and hip decompression supplemented with adipose derived regenerative cells in patients with osteonecrosis in both of their hips.

The purpose of this study is to develop a research repository (a repository is a database of information) to collect data from patients being treated for hip disorders.

Aim #1: The aim of this research is to examine the results of periacetabular and femoroacetabular osteoplasty procedures in patients with symptomatic non-arthritic hip disease using clinical and radiographic evaluation.

The purpose of this study is to determine if the concentration of mesenchymal stem cells in the joint fluid of the hip increases to compare with the severity of the disease in patients with osteonecrosis ( bone decay) of the femoral head (leg bone/hip joint).

The purpose of this study is to determine potential genetic predisposition to FAI through NGS in a family with multigenerational disease.  Provide genetic counseling and orthopedic management options to family members with unknown disease status.  Establish screening and risk-stratification parameters via NGS through publication of genetic abnormalities associated with FAI.

We plan to analyze patient satisfaction, radiographic outcomes, and complication rates for young patients undergoing primary total hip arthroplasty at ten year follow up. At the current time, little is known about patient outcome in this age group with the above length of follow up.

Hip dysplasia is a complex problem that exists on a spectrum from mild to severe disease. Periacetabular osteotomy (PAO) remains the gold standard for most patients with dysplasia; however, the procedure is quite invasive making the decision to proceed in cases of mild disease difficult. Hip arthroscopy (HA) is an alternative minimally invasive technique that can be used to address mild dysplasia. Nevertheless, HA has less capability for correction and in rare instances can exacerbate instability in the dysplastic hip. There is a paucity of data examining outcomes between these two treatment strategies for this challenging problem.

Tears of the abductor tendons have become an evermore-recognized source of debilitating lateral hip pain. Two broad surgical approaches have been described to manage these tears: repairing the tendons or performing a transfer of the Gluteus Maximus tendon. While a classification system has already been proposed to describe tear morphology and quality of the gluteus medius muscle on preoperative magnetic resonance imaging, little evidence is available to guide treatment (reconstruction versus muscle transfer).