Megha M. Tollefson, M.D.

The purpose of this research is to see if a new topical (applied to the skin) formulation of sirolimus, PTX-022, is safe and effective in treating people with microcystic Lymphatic Malformations (mLM). 

The purpose of this study is to develop a better understanding of the cause and natural history of vascular anomalies, discrepancies of growth, and related syndromes.

The purpose of this study is to evaluate how children and young adults perceive their midline sternotomy scars (in terms of appearance, associated symptoms, consciousness, satisfaction with appearance/symptoms, and impact on quality of life)? 

The purpose of this study is to develop a registry to collect long-term data on patients with pediatric cutaneous mastocytosis, and develop better knowledge of the timing, symptoms, resolution or progression of the disease, and predictive markers of its severity.

The purpose of this study is to create a research registry of patients with Immune-Mediated Inflammatory Skin Conditions (IMISC) within academic and community, real-world practices in order to assess the safety and effectiveness of current and future therapies.

This study is a 2-part (parts A and B) phase 2/3 study to evaluate the safety, pharmacokinetics (PK) and efficacy of dupilumab in patients 6 months to less than 6 years of age with severe atopic dermatitis (AD).

The purose of this study is to compare the safety and effectiveness of two different strengths of Rapamycin cream, topical and placebo over 26 weeks in the treatment of facial angiofibroma (FA) associated with Tuberous Sclerosis Complex (TSC).

The purpose of this extension study is to evaluate the effectiveness and safety of two dosage strengths of PF-04965842, 100 mg and 200 mg taken orally once daily, over approximately two years of study participation. Patients who meet safety step-down criteria will have their dose reduced once, from 200 mg QD to 100 mg QD, or from 100 mg QD to placebo.

The purpose of this study is to investigate PF-04965842 in patients aged 12 years and over with a minimum body weight of 40 kg who have moderate to severe atopic dermatitis.

The purpose of the study is to assess the effectiveness and safety of ruxolitinib cream in children with atopic dermatitis.

The primary purpose of this study is to evaluate the clinical effectiveness of apremilast compared with placebo in children and adolescents (ages 6 through 17 years) with moderate-to-severe plaque psoriasis.

The primary purpose of this two-part study is to evaluate the safety and tolerability of VT30.  

Part 1 is a 4-week treatment, open-label, 4-sequence, escalating repeat-application cohort study, with intra-subject and inter-cohort dose escalation.

Part 2 is a 12-week treatment, randomized, placebo-controlled, double-blind, safety and exploratory effectiveness study. Part 2 will be initiated only after the successful completion of Part 1 with results that demonstrate the general safety and tolerability of topically applied VT30. 

The purpose of this study is to evaluate the effectiveness of a specific and inexpensive topical approach to lowering the burden of flares in children with atopic dermatitis.  

The current clinical guidelines for management of atopic dermatitis now recommend bleach baths. This requires simply the addition of regular household bleach to twice-weekly baths. At the Mayo Clinic, dilute acetic acid (vinegar) has been recommended for decades in wet wraps to treat patients hospitalized for their atopic dermatitis. However, this practice has not been widely adopted in the pediatric dermatology community. Will the use of dilute acetic acid (vinegar) in twice weekly baths help manage atopic dermatitis in pediatric patients as well as, or better than, the current accepted guidelines?

The goal of this study is to objectively evaluate bone health and contributing factors in children with Atopic Dermatitis (AD). 

The goal of this study is to determine whether or not patients with overgrowth syndromes have decreased bone density.

The purpose of this study is to identify the key elements of the clinical discussion between patients and clinicians regarding acne treatment and to develop an evidence-based decision aid for acne treatment. 

Multi-center, double-masked randomized, efficacy, safety and pharmacokinetic (PK) study.

The purpose of this study is to develop a resource (bank) of biospecimens and data collected from individuals with a vascular tumor or malformation to facilitate discovery and development of novel biomarkers for diagnosis and treatment of disease, better elucidate etiologic factors relating to vascular anomalies, and novel targeted therapeutic strategies for vascular anomalies.

The purpose of this study is to use a validated survey tool to find health related quality of life scores for patients with vascular malformations or vascular malformation-overgrowth syndromes, to assess for potential differences in health related quality of life between patients with vascular malformation versus vascular malformation-overgrowth syndromes, as well as stratify across other variables including demographics and disease severity, and to compare health related quality of life in our patient population to that of the general population as well as to other well-studied chronic medical conditions.

The purpose of this project is to determine the genetic causes of disease and establish accurate clinical indicators and biomarkers of disease activity with an overall goal of improving care for patients with morphea.

The purpose of this research is to develop a better understanding of the cause of vascular overgrowth syndromes and to develop a clinically relevant classification system. The researchers will also seek to determine if there is a relationship between the specific gene mutation and the clinical features (genotype-phenotype correlation).

The purpose of this study is to survey parents or caregivers of children with psoriasis regarding their quality of life with the newly-developed Psoriasis Caregiver Impact Scale (PsoriaCIS).

The purpose of this study is to develop a psoriasis-specific tool to assess the quality of life of the parents and caregivers of children with psoriasis.

The purpose of this study is to identify the long-term occurrence of non-melanoma skin cancers in patients who had ultraviolet light therapy as a child in the years 1970 to 2000.

This study leverages the availability of a validated series of instruments to measure the effect of highly visible, chronic skin disorders, including atopic dermatitis (AD), on patients 8 years of age and above in causing stigma and psychiatric issues, particularly anxiety and depression.