Aaron J. Krych, M.D.

The main purpose of this study is to evaluate the clinical and functional outcomes of patients undergoing biologic knee preservation surgery. Secondary purpose is to identify possible correlation between outcome and pre-operative radiological findings (i.e. bony abnormalities such as mal-alignment, size of cartilage defect).

The purpose of this investigation is to characterize the genetic and epigenetic characteristics of different musculoskeletal tissues, as well as their associated disease states. Epigenetic markers represent promising therapeutic targets, as well as diagnostic biomarkers with important clinical utility.

The purpose of this study is to evaluate the clinical and functional outcomes of patients undergoing arthroscopic shoulder surgery.

The overall primary objective of this 21-site international randomized trial is to determine if graft type (QT, BPTB or HT) with or without a lateral extra-articular tenodesis (LET) will affect the rate of Anterior Cruciate Ligament (ACL) clinical failure 2 years after surgery.

This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection. Researchers will collect this data from the time of baseline visit, which is within 28 days of injury, through the temporal sequence of post-operative or post-injury recovery and return to activity.

The hypotheses for this study are (1) that T1ρ and T2 will be significantly elevated in the lateral side of ACL-injured knees immediately after injury (indicating damage caused by initial injury), and will not fully recover at 6-month, 1-year follow ups; (2) that T1ρ and T2 will be significantly elevated in the medial side of ACL-injured knees at 1-year follow-up; and (3) that differences in the bio-marker expression patterns can be correlated with the initial MRI findings, which would provide information regarding the full spectrum of intra-articular pathology and the subsequent clinical outcomes.

The purpose of this research study is to gather information on the safety and effectiveness of Autologous Chondrocyte Transplantation system, Novocart® 3D, in comparison to standard microfracture treatment for injured knee.

The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee. The patient population is heterogeneous, involving different kinds of joint surface lesions: focal cartilage lesions, osteochondral defects and mild to moderate osteoarthritis, including multiple defects.

Horizontal meniscus tears meeting specified criteria will be repaired by any commonly used suture technique. Subjects will be followed for 2 years to evaluate the effectiveness of the repair, by assessing the re-operation rate, and by assessing improvements in knee pain and knee function.

This confirmatory study is a prospective randomized trial comparing the efficacy and safety of an autologous chondrocyte tissue implant (NeoCart) to the surgical intervention microfracture in the treatment of cartilage defects in the knee.

The purpose of this study is to investigate the outcomes for middle-aged and elderly patients who have a traumatic shoulder dislocation resulting in a bony Bankart injury.

Capsular REpair randomiSed controlled Trial (CREST) is a multi-center, randomized controlled trial with a sample size of 240 patients (120 patients in each group). The primary outcome measure is functional outcome as measured by the change in Hip Outcome Score at 6 months with secondary outcomes being hip range of motion, i-HOT 12, overall satisfaction, and VAS. Patients are stratified based on gender. Patients, outcome assessors, and data analysts are blinded to surgical allocation. Using an intention-to-treat approach, outcome analyses will be performed using an analysis of covariance and descriptive statistics.

The primary objective of the study is to assess the local and systemic safety of a single operative application of autologous chondrons mixed with culture expanded allogeneic AMSCs (RECLAIM) in the treatment of symptomatic focal cartilage defects of the hip.

The secondary objectives of the study are to assess the effect of RECLAIM on pain and function in the target hip, and to assess the effect of RECLAIM on bone and cartilage structures within the target hip using MRI.

The primary objective of this registry is to obtain long-term survivorship data for the use of fresh OCAs in cartilage repair and reconstruction procedures.

The overall goal of this project is to reduce risk of second anterior cruciate ligament (ACL) injury in vulnerable populations (active athletes between 14 = 24 years old) through the identification of relative injury risk groups based on subject-specific movement patterns prior to second injury, as well as through the determination of effect for differential rehabilitation protocols following initial ACL reconstruction and prior to return to sport. As nearly one-third of athletes who have a primary ACL injury and return to sport will experience a secondary injury, results from the proposed work will allow us to prospectively identify high risk patients who are the most appropriate recipients of enhanced treatment, including targeted training, which may reduce the risk of second ACL injury. Secondary ACL injury has the potential to end athletic careers, promote the development of osteoarthritis, and have debilitating effects on quality of life. Hence, the information gathered in this investigation will offer ACL injured athletes the optimal potential to reduce or potentially prevent these negative health effects before they are initiated.

The purpose of this study is to compare individuals with meniscal root tears that are treated surgically with a meniscal root repair compared to those that are treated without surgery and instead receive anti-inflammatory medications, physical therapy and have a temporary period in which they do not put any weight on the leg.

The purpose of this study is to gather clinical outcomes data and imaging for patients who are receiving Cartiform for articular cartilage defects as a standard of care treatment.                                           

The purpose of this study is to test the safety of this novel cell, combination- based regenerative therapy for use in patients with symptomatic focal cartilage defects of the knee.

This study will assess the effect of incorporating a tonal exercise device into clinical and chiropractic care for lower back pain. 

The purpose of this study is to validate the patient approved knee assessment (PAKA) by providing the questionnaire to patients to assess patient needs, formulate a questionnaire based on this information, and finally validate the questionnaire in assessing the same outcomes as existing questionnaires for clinical use.