Bart M. Demaerschalk, M.D.

The purpose of this study is to assess if patient outcomes are improved when the Comprehensive Stroke Center/Primary Stroke Center (CSC/PSC) system is supplemented with an Integrated Stroke Practice Unit (ISPU) system of care, a patient-centric model of care involving the patient and caregiver/family that coordinates care from the acute management through the rehabilitation and recovery of the patient.

The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial study is to assess post-procedural efficiency of carotid endarterectomy and carotid stenting.

The purpose of this study is to examine the relationship between stroke risk stratification categories, according to ABCD2 scoring and post-ischemic stroke status, and passively- and actively collected data (from a smartphone application). Also, to investigate patterns of changes in behavioral and physiological states associated with a stroke event. Addtionally, to explore whether digital phenotyping can provide a valid, useful method for tracking behavioral and physiological changes over time. If our proposed protocol is validated, it has the potential to be applied in both clinical and research settings to improve stroke screening for older adults

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.