Lily C L Wong-Kisiel, M.D.

The purpose of this study is to evaluate the long-term safety and tolerability of cenobamate adjunctive therapy in subjects with primary generalized tonic-clonic (PGTC) seizures who have completed the Core Study YKP3089C025.

The purpose of this study is to demonstrate the efficacy of adjunctive cenobamate 200 mg dose (or the adolescent equivalent) compared with placebo on Primary Generalized Tonic-Clonic (PGTC) seizures in subjects ≥ 12 years of age.

The primary purpose of this study is to evaluate the safety and tolerability of cenobamate in pediatric subjects 2 to ≤ 18 years of age with partial-onset (focal) seizures.

The seconday objectives of this study are to evaluate the efficacy of cenobamate tablets and suspension in pediatric subjects with partial onset (focal) seizures, to collect plasma samples of cenobamate to support the evaluation of the pharmacokinetics of cenobamate tablets and suspension in pediatric subjects with partial onset (focal) seizures, to collect plasma samples of cenobamate to support the evaluation of the PK/pharmacodynamics of cenobamate in pediatric subjects with partial onset (focal) seizures, and the acceptability and palatability assessment (determined by a 5-point Hedonic Scale) of the oral formulation and tablets – Day 1, and Day 15.

The purpose of this study is to evaluate the long-term safety and tolerability of NBI-921352 when administered for up to 106 weeks. Also, to investigate the effect of NBI-921352 on long-term seizure control.

The primary objective of this study is to create common data elements collected at all centers participating in this collaborative allowing for direct data comparison amongst participating centers. Secondary objectives will compare how Pediatric Epilepsy Centers evaluate surgery candidates in order to inform future studies to compare and potentially standardize the process.

The objectives of this study are to assess the effectiveness of NBI-921352 as adjunctive therapy on the frequency of countable motor seizures (defined as generalized tonic-clonic seizure [GTCS], tonic, atonic or focal onset   seizures [FOS] with noticeable motor component), to evaluate the effectiveness of NBI-921352 using the Clinical and Parent/Caregiver Global Impression of Change scales and the Clinical and Parent/Caregiver Global Impression of Severity scales, to explore the effect of NBI-921352 on symptoms and seizure activity, physical activity, quality of life, as well as seizure freedom. to characterize the pharmacokinetics (PK) of NBI-921352 and determine the effect of NBI-921352 on plasma levels of concomitant antiseizure medications (ASMs) and evaluated metabolites. and to evaluate the safety and tolerability of NBI-921352.

The purpose of this study is to find out how the ketogenic diet may affect the quality of life of children.

The purpose of this study is to collect medical information from a group of infants in order to better understand West syndrome. EEG tests are usually ordered when infants have movements that look like seizures or infantile spasms. If there is hypsarhythmia, then the doctors know to give the specific treatment for West syndrome. We would like to see if there is EEG pattern that is always present even before the infantile spasms start and West syndrome diagnosed.