Sun-Hee Lee, Ph.D.

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• Assessing Dynamic Changes in the Plasma Proteome to Identify Clinically Relevant Early Detection and Treatment Response Biomarkers for High Grade Serous Ovarian Cancer - A CPTAC Pilot Project Rochester, Minn.

  This study aims to identify candidate High Grade Serous Cancer (HGSC) early detection and chemotherapy treatment response biomarkers.  For the purpose of this study we define high grade serous cancers to include invasive cancers arising in the ovary and/or fallopian tubes (FT).  Using mass spectrometry we will deeply profile and quantitate dynamic changes in the plasma proteome and N-gylcocapture sub-proteome that occur as a consequence of surgical debulking and platinum-based chemotherapy.