Julia S. Lehman, M.D.

Closed for Enrollment

• A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Oral BTK Inhibitor PRN1008 in Moderate to Severe Pemphigus Rochester, Minn.

  The purpose of this study is to evaluate the effectiveness and safety of oral PRN1008 in moderate to severe pemphigus.

• Development of diagnostic and prognostic tissue-based biomarker assays for inflammatory dermatoses Rochester, Minn.

  Inflammatory dermatoses are sometimes difficult to diagnose with accuracy using current methods (clinical examination and routine skin biopsy). Targeted therapies (biologics) are available for severe inflammatory dermatoses, but selection of which particular biologic agent to use is often arbitrary. Trials of these medications are expensive and may be multiple before an effective treatment is found.
  We propose to develop tissue-based biomarker assays for the diagnosis and therapeutic prognosis for inflammatory skin diseases.

• Diagnostic and Prognostic Validity of Tissue-based Biomarker Assay for Acute Graft-versus-host Disease of the Skin: A Retrospective Study Scottsdale/Phoenix, Ariz., Rochester, Minn., Jacksonville, Fla.

  The purpose of this study is to validate the diagnostic and prognostic utility of our tissue-based assay, the aim is to perform a multi-institution, retrospective study of our assay compared with the current clinical gold standard (clinicopathologic correlation and prospective observation of clinical course, respectively). 

• Methods Validation Assessment for Study of Inflammatory Skin Disease Rochester, Minn.

  The purpose of this study is to assess the degree of signal alterations or attenuation in formalin-fixed vs. fresh skin biopsy specimens of inflammatory skin disease, using molecular methods .