Faculty

Brian A. Neff, M.D.

Clinical Studies

A Phase 1/2 Trial of AAVAnc80-antiVEGF Gene Therapy in Individuals with Unilateral Vestibular Schwannoma Rochester, Minn.
The purpose of this study is to assess the safety, tolerability, and bioactivity of escalating doses of AAVAnc80-antiVEGF administered via unilateral intracochlear administration (using the investigational delivery device as part of a delivery system).
Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Patients with Vestibular Schwannoma Rochester, Minn.
The purpose of this study is to evaluate whether the administration of aspirin can delay or slow tumor growth and maintain or improve hearing in patients with vestibular schwannoma (VS).
Quantification and Standardization of Eosinophilic Cationic Protein, Major Basic Protein, and IL-5 in Chronic Otitis Media Fluid Samples Rochester, Minn.
During myringotomy and possibly a tube insertion procedure a small amount of fluid that is being removed from the middle ear (whether or not you participate in the study) will be examined for different proteins or it may be saved and used for future research studies.

Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Rochester, Minn.
The purpose of this study is to assess the use of AR-42 in adult patients undergoing NF2-tumor removal. AR-42 is a small molecule which crosses the blood brain barrier (BBB) in rodents, but the investigators are not certain yet if it will penetrate human Vestibular Schwannoma. Meningiomas are outside the BBB, but also seem to be unusually resistant to all current medical treatments.
Quantification and Standardization of Eosinophilic Cationic Protein, Major Basic Protein, and IL-5 in Chronic Otitis Media Fluid Samples Scottsdale/Phoenix, Ariz.
During myringotomy and possibly a tube insertion procedure a small amount of fluid that is being removed from the middle ear (whether or not you participate in the study) will be examined for different proteins or it may be saved and used for future research studies.