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Clinical Studies
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ARrest RESpiraTory Failure From PNEUMONIA (ARREST PNEUMONIA) (ARREST)
Rochester, Minn.,
Jacksonville, Fla.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to establish the effectiveness of a combination of an inhaled corticosteroid and a beta agonist compared to placebo for the prevention of acute respiratory failure (ARF) in hospitalized patients with pneumonia and hypoxemia.
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Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles for Hospitalized Patients With Moderate-to-Severe ARDS: A Phase III Clinical Trial (EXTINGUISH ARDS)
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.,
Jacksonville, Fla.
The purpose of this study is to evaluate the safety and effectiveness of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitalized patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
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Pilot Clinical Trial of a home-based program of rehabilitation with health coaching to improve outcomes in post-intensive care syndrome patients
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to develop further and test the feasibility, safety, and efficacy of a home-based, nurse health coach-facilitated program of PR, physical activity and symptom monitoring, and comprehensive remote health coaching intervention that aims to improve health-related quality of life (HRQoL), daily physical activity, Post ICU Syndrome (PICS) domain-specific impairments, caregiver burden, and healthcare utilization in PICS patients from hospitals with distinct location, diversity, and practice settings.
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Predicting Acute Respiratory Distress Syndrome (ARDS) and Acute Respiratory Failure (ARF) after Hematopoietic Stem Cell Transplantation (HSCT)
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to deepen our understanding of the ARDS mechanism following transplantation through an analysis of cytokines, metabolomics and proteomics before ARDS occurs, and during the early phase of ARDS development.
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'Use of Midodrine in Septic Shock Patients
Rochester, Minn.,
Mankato, Minn.,
Eau Claire, Wis.,
Jacksonville, Fla.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to evaluate the effect of oral midodrine administration on vasopressor-free days in patients with septic shock (primary outcome).
Closed for Enrollment
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Community Engagement to Address Disparities in Complex Care for Spanish-Speaking Patients with Limited English Proficiency
Rochester, Minn.,
Jacksonville, Fla.,
Scottsdale/Phoenix, Ariz.
The purpose of this research is to identify appropriate strategies to address complex care decision-making and the needs of Spanish-speaking patients with limited English proficiency, as well as their caregivers, family members, and community members.
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Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations
Rochester, Minn.,
Jacksonville, Fla.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.
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Mechanistic Effects of Health Coaching to Reduce COPD Hospitalizations
Rochester, Minn.,
Scottsdale/Phoenix, Ariz.
The purpose of this study is to explore the benefit of Health Coaching on patients with COPD versus self guided lifestyle education. The goals are to see if Health Coaching improves well-being and quality of life and physical activity in patients with COPD and also if the benefits are maintained overtime (lifestyle change). This study will also be looking at how often a patient visits the doctor unscheduled for COPD related causes.
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