David J. Daniels, M.D., Ph.D.

The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.

The purpose of this research study is to further our understanding of syringomyelia and Chiari malformations. This study is being done to learn about the underlying causes, natural history, and optimal treatment of syringomyelia and Chiari malformations.

The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia.

The purpose of this study is to generate endothelial and smooth muscle cell lines from patients with brain arteriovenous malformations (AVM)s for subsequent use in cell culture (and eventually animal models) in order to delineate the underlying cell, molecular, genetic, and epigenetic features of brain AVMs.

The purpose of this study is to verify the gene array data by examining the protein expression in brain tissue of diffuse intrinsic pontine glioma (DIPG) patients compared to normal healthy subjects using western blot.

The purpose of this registry is to use a comprehensive database to study syringomyelia and chiari 1 malformation, the natural history, and clinical course following treatment in a large number of patients, and use advanced magnetic resonance imaging, CT and x-ray imaging to study the pathophysiology of the condition.