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BD2 Integrated Network
Scottsdale/Phoenix, AZ
Rochester, MN
This research study is designed to fill gaps in our understanding of bipolar disorder. This study involves collecting information from participants to answer key questions relevant to bipolar disorder which might help change or improve the way we do things in the future. This is an observational study and does not involve any additional treatment beyond your standard care at the clinic.
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Central And Peripheral GABA And Glutamate Modulation With Intravenous Ketamine For Treatment-Resistant Depression (G2K): A Randomized, Double-Blind, Placebo-Controlled Study (G2K)
Rochester, MN
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA and Glu levels from baseline to 24-hr postinfusion utilizing LCMS, with baseline to 24-hr post-infusion change in depression (MADRS) in 30 TRD adults.
Closed for Enrollment
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Central versus Peripheral Glutamate Biomarkers for Treatment Response during Two Infusions of Intravenous Ketamine for Treatment-Resistant Depression
Rochester, MN
This feasibility study aims to better understand the neurobiology of major depression and how ketamine may therapeutically impact brain function. This research may provide important insights into the mechanism of ketamine response, thus, potentially increasing the likelihood of successful treatment interventions and decrease the number of ineffective treatments and/or risk for serious side effects.
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Chronobiology And Depression: Circadian Analytics As A Biomarker For Diagnosis And Longitudinal Monitoring Of Depressive Subtypes
Rochester, MN
The purpose of this study is to explore whether Medibio’s system can provide objective measures of response to standard medication treatment for unipolar depression and bipolar depression, and to see if the system can tell these two conditions apart.
Medibio’s system uses software to analyse a person’s heart rate, activity, and posture to provide objective measures of a person’s autonomic nervous system, sleep, and other daily patterns.
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Long-term Outcomes of a Clinical Ketamine Service for Treatment-resistant Depression
Rochester, MN
The purpose of this study is to evaluate and analyze the clinical data that is already being collected for clinical purposes to determine the long-term effects of the repeated use of subanaesthetic ketamine/esketamine for patients with depression. We hypothesize that patients who have a greater number of infusions/treatments will be more likely to have increased side effects to the drug. We would like to be able to also analyze data related to any other assessments that are implemented as part of the clinical practice in the future.
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