Casey M. Clements, M.D., Ph.D.

Closed for Enrollment

• A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis. (VICTAS) Rochester, Minn.

  The purpose of this study is to investigate the effectiveness of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the effectiveness of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.

• Implementation of a Shared Decision-Making Intervention in Practice: The Chest Pain Choice Pathway Rochester, Minn.

  The purpose of this study is to incorporate the Chest Pain Choice decision aid in a stakeholder-guided evidence-based clinical practice pathway, to implement it in practice, and to evaluate its effects — potential to improve patients’ experience of care while simultaneously limiting unnecessary healthcare utilization and improving population health.

• Inflammatix, Inc. / TriVerity in the Diagnosis and Prognosis of Emergency Department Patients with Suspected Infections and Suspected Sepsis (SEPSIS-SHIELD)(MCBD) (SEPSIS-SHIELD) Rochester, Minn.

  The purpose of this study is to analyze biological samples collected from participants with suspected infections to test the efficacy of the InSep test in development.

• Specificity of Physician Concern for Severe Sepsis Rochester, Minn.

  The purpose of this study is to determine the accuracy and clinical usefulness of a physicians impression prior to having objective laboratory data or imaging results for the diagnosis of sepsis.

• Study to Compare SeLux Rapid Blood Culture Method with Standard-of-Care: SLD002-20 BAC (SLD002-20 BAC) Rochester, Minn.

  The purpose of this study is to evaluate the positivity rate of the Selux rapid blood culture platform compared with the  standard clinical platform using blood samples drawn from adult patients with suspected septicemia or bacteremia.