Osama A. Abulseoud, M.D.

This research study is designed to fill gaps in our understanding of bipolar disorder. This study involves collecting information from participants to answer key questions relevant to bipolar disorder which might help change or improve the way we do things in the future. This is an observational study and does not involve any additional treatment beyond your standard care at the clinic.

Aim 1: To test the efficacy of melatonin in attenuating post-COVID cognitive impairment.

Aim 2: To utilize multimodal imaging to study the changes in brain iron content, resting state functional connectivity, and working memory network task activation after 12 weeks of melatonin treatment.

Aim 3: To compare baseline brain iron content, resting state functional connectivity, and working memory network task activation differences between patients with post-COVID cognitive impairment and age- and sex-matched healthy controls.

The purpose of this study is to create a larger database and bio-repository to examine pharmacogenomics in patients with BD type I and type II treated with mood stabilizing anticonvulsants, atypical antipsychotics and antidepressant medications.