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Clinical Studies
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Comparison of Flexor Hallicus Brevis and Adductor Pollicis as Sites for Neuromuscular Monitoring with Electromyography (Thumb vs Great Toe) after Sugammadex Administration
Jacksonville, Fla.
The purpose of this study is to assess the onset of neuromuscular blockade and recovery profiles of aminosteroidal neuromuscular blocking agents (NMBAs) after sugammadex at the flexor hallucis brevis (great toe) and adductor pollicis (thumb) muscles.
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Comparison of onset of Neuromuscular Blockade with Electromyographic and Acceleromyographic Monitoring: A Prospective, Randomized Trial
Jacksonville, Fla.
The primary aim of this study is to compare the time difference from neuromuscular blocking agent (NMBA) administration to neuromuscular blockade (NMB) onset defined as a train-of-four count (TOFC) equal to 0, utilizing electromyographic (EMG) vs. acceleromyographic (AMG) neuromuscular monitors while intubating conditions are being evaluated.
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Comparison of the ToFscan and TetraGraph during Recovery of Neuromuscular Function in the Post Anesthesia Care Unit
Jacksonville, Fla.
The purpose of this study is to assess the agreement and repeatability between TOF values obtained from ToFscan and TetraGraph.
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Comparison of Visual and Electromyography Assessments in Response to Train-of-Four Stimulation of the Ulnar Nerve
Jacksonville, Fla.
The purpose of this study is to correlate the objective electromyography (EMG)-derived data (TOFR, TOFC, PTC) with subjective (blinded) evaluation of responses using the TetraGraph.
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Correlation Between Cardiac Output and Recovery Time After Reversal of Rocuronium-Induced Blockade with Sugammadex (CO and TOF)
Jacksonville, Fla.
The purpose of this study is to evaluate the cardiac output measurements during patient's recovery from anesthesia and determine if there is correlation between the cardiac output measurement and residual neuromuscular blockade
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Ease of Application of Various Neuromuscular Devices for Routine Monitoring
Jacksonville, Fla.
The purpose of this study is to determine how long it takes anesthesia providers to apply various neuromuscular monitors that are utilized to determine the depth of neuromuscular blockade.
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Electromyographic and Acceleromyographic Monitoring in Restricted Arm Movement Surgical Setting
Jacksonville, Fla.
The purpose of this study is to compare the ease of use and repeatability of Electromyographic (EMG) vs. Acceleromyographic (AMG) neuromuscular responses in surgical settings in which the patients’ arm movement is restricted (placed under surgical drapes) in laparoscopic or robotic procedures.
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Electromyographic Assessment of the TetraGraph in Normal Volunteers
Jacksonville, Fla.
The purpose of this study is to get performance data on the TetraGraph, to see if it is an easy-to-use and accurate quantitative neuromuscular monitor, by testing it on normal volunteer adults.
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Electromyographic Monitoring and Postoperative Recovery
Jacksonville, Fla.
The aim of this study is to determine whether EMG monitoring in the operating room reduces the incidence of postoperative residual blockade (measured at the time of tracheal extubation and on arrival to the PACU).
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Electrophysiological Comparison of mAP and mADM Using EMG
Jacksonville, Fla.
The primary aim of this clinical investigation is to examine a prototype of a quantitative monitoring instrument that will meet most, if not all, of the clinical requirements.
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Randomized Double-Blinded, Controlled Trial to Compare the Effectiveness of Sugammadex versus Placebo to Prevent Residual Neuromuscular Block in the Post-Anesthesia Care Unit as Evaluated with a Non-Invasive Respiratory Volume Monitor
Jacksonville, Fla.
The purpose of this study is to determine whether patients who receive sugammadex immediately after the removal of a surgical breathing tube will have a decrease in the incidence of postoperative residual paralysis and an associated decrease in the incidence of postoperative respiratory depression.
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The Role of Sugammadex and Quantitative Monitoring in “Fast-Track Anesthesia” During Liver Transplantation (TG Sgx OLT)
Jacksonville, Fla.
The purpose of this study is to determine the incidence of postoperative residual weakness (a train-of-four ratio < 0.9) in patients getting ‘fast track anesthesia’ following liver transplantation. Our clinical practice routinely utilizes sugammadex in this patient population and we have anecdotally observed excellent outcomes. We hypothesize that the incidence of postoperative residual weakness with sugammadex and quantitative monitoring is low (<5%) and that patients receiving fast track anesthesia have shorter hospital length of stays than the national average (12). Additionally, postoperative pulmonary complications (PPC) can occur from residual weakness. We will utilize previous definitions of PPCs (13). Specifically, postoperative pneumonia within 30 days or respiratory failure that requires unplanned non-invasive mechanical ventilation (such as bilevel positive airway pressure ventilation) or need for reintubation due to respiratory distress will be documented.
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