Christopher H. Evans, Ph.D.

Closed for Enrollment

• A Phase I Study Evaluating the Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Osteoarthritis of the Knee (AAVIL-1Ra) Rochester, Minn.

  The purpose of this study is to determine the safety of sc-rAAV2.5IL-1Ra, a gene therapy carried by a virus and delivered by injection into the knee joint of patients with moderate osteoarthritis of the knee.

• Establishing and Validating Standard Operating Procedures for Assays on Synovial Fluid Rochester, Minn.

  The purpose of this study is to find out whether knee joint fluid (synovial fluid) contains substances which may interfere with laboratory tests not normally done on synovial fluid. 

• Whole Genome Sequencing of a Patient with Early Onset Osteoarthritis Rochester, Minn. The purpose of the study is to identify a possibly novel mutation in an individual with early onset osteoarthritis.