Devang K. Sanghavi, M.B.B.S., M.D.

The purpose of this study is to evaluate the effect of oral midodrine administration on vasopressor-free days in patients with septic shock (primary outcome).

The long-term goal of this research is to provide a basis for further study of intravenous ketamine infusions compared to placebo intravenous saline infusions to improve depressive symptoms in depressed patients in the Intensive Care Unit.  First, it is important to provide preliminary evidence of the potential improvement in depressive symptoms with intravenous ketamine infusions compared to placebo intravenous saline infusions and to learn about unanticipated challenged of conducting a double-blinded randomized trial.

The objective of this randomized double-blind clinical trial is to obtain initial evidence of the potential benefit of intravenous ketamine infusion compared to placebo intravenous saline infusion for the treatment of depressive symptoms among patients in the ICU and use those estimates to design a larger, multi-center, randomized trial. 

All patients will be receiving standard psychiatric care for any underlying psychiatric condition and standard psychiatric follow‐up by their non-study psychiatrist, who will be making any changes in the treatment deemed warranted by the patient’s condition.

As a part of the COVID-19 pandemic, Mayo Clinic Florida is utilizing remote monitoring technology to monitor non-ICU patients in order to identify patients who will need the ICU and prevent crashing patients on the floor. MCF is using approved InTouch video and Biofourmis remote vital sign monitoring technology, both used by Mayo Clinic in other capacities. This study will not be a study of the efficacy or the accuracy of these devices as they are already incorporated as standard of practice. This study will assess the reduction of on floor crashing patients, quality of care, and satisfaction of providers by using this technology.  

The purpose of this study is to compare measurements of blood pressure (BP) between the Philips non-invasive blood pressure (NIBP) system (including NIBP cuff and portable patient monitor) and invasive radial arterial line (A-line) in critical care patients.