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A Long-term Follow-Up Study to Evaluate the Safety and Efficacy of RGX-314 Following Subretinal Administration in Participants with Neovascular Age-related Macular Degeneration and Fellow Eye Treatment Substudy
Rochester, Minn.
The purpose of this study is to evaluate the long-term safety and efficacy of RGX-314.
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A Randomized, Partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants With nAMD (ASCENT)
Rochester, Minn.
The purpose of this study is to investigate the effectiveness and safety of two doses of RGX-314 administered as a single subretinal injection in the study eye of patients with nAMD, and to evaluate mean change from baseline in best-corrected visual acuity (BCVA) of RGX-314 relative to aflibercept at Week 54.
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Prevalence and Risk Factors for Pentosan Polysulfate Maculopathy: A Population-Based Analysis (PPS)
Rochester, Minn.
The purpose of this study is to to address the current lack of a true prevalent diagnosis of interstitial cystitis and perform outreach to prospectively screen patients with multimodal retinal imaging including fundus examination, fundus autofluorescence, spectral domain optical coherence tomography, and near infrared reflectance imaging by utilizing the Rochester Epidemiology Project (REP). Additionally, this study aims to provide additional insights into the risk of PPS maculopathy, investigate additional risk factors for PPS maculopathy development, and inform development of evidence-based screening guidelines.
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Vitreous Cavity Bacterial Contamination and Vitreous Fluidics after Vitreoretinal Surgery
Rochester, Minn.
The objective of this study is to evaluate and determine factors such as surgical technique, length of surgery, and surgical instrumentation associated with bacterial contamination of vitreous fluid following vitreoretinal surgery.
Closed for Enrollment
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A Phase 2, Prospective, Multicenter, Randomized, Double-Masked, Active-Controlled Study to Assess the Safety, Tolerability, and Evidence of Activity of a Repeat Intravitreal Injection of UBX1325 in Patients with Neovascular Age-Related Macular Degeneration
Rochester, Minn.
A Phase 2, Prospective, Multicenter, Randomized, Double-Masked, Active-Controlled Study to Assess the Safety, Tolerability, and Evidence of Activity of a Repeat Intravitreal Injection of UBX1325 in Patients with Neovascular Age-Related Macular Degeneration
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