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  • Advanced MR and PET Imaging in Inflammatory Demyelinating Diseases of the Central Nervous System Rochester, Minn.

    The purpose of this study is to investigate white matter myelin integrity using Pittsburgh compound-B positron emission tomography (PiB PET) imaging in patients in different phases of MS and related disorders. Also, to measure neuroinflammation and microglial activity using translocator protein 18 (TSPO) PET imaging in different phases of MS and related disorders. In addition, to determine if white matter integrity and neuroinflammation measured by PET imaging, are associated with disease course, clinical disability accumulation and other imaging markers of disease burden in MRI, MR spectroscopy MRS and DTI.
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