Gustavo A. Cortes Puentes, M.D.

Open

• Evaluating the Impact of Gender-Affirming Treatments on Pulmonary Function in Transgender and Gender Diverse (TGD) Patients Rochester, Minn.

  The purpose of this study is to evaluate the longitudinal changes in lung volumes and spirometry parameters, after both masculinizing and feminizing hormone therapy in transgender and gender diverse (TGD) patients. Also, to determine the time of “gender adjustment” of PFT’s (pulmonary function test) normative values (PFTs results correlate most closely with patient’s gender than with their sex-assigned at birth) in response to gender-affirming hormone therapy in transgender and gender diverse (TGD) patients. Additionally, to implement a personalized approach to PFT interpretation using gender-appropriate normative values in transgender and gender diverse (TGD) patients, during the transition period and after attaining end points of gender transition.

• Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure: A Feasibility, Double Arm, Single-blinded Study. Rochester, Minn.

  The purpose of this study is to assess the feasibility of implementation of, and adherence to VentCoach protocol in critically ill patients intubated for acute hypoxemic and/or hypercapnic respiratory failure. We hypothesize that, when compared to standard of care, VentCoach is feasible, safe, and easy to implement]