Mohsen Khosravi Maharlooei, M.D.

Open

• Studying Regulatory T Cells and Functional Markers of Immune Tolerance in Liver Transplant Patients with Spontaneous Operational Tolerance Scottsdale/Phoenix, Ariz.

  The purpose of this study is to determine if specific immune signatures, indicative of a balanced immune response and graft acceptance, will distinguish tolerant patients from those requiring ongoing immunosuppressive therapy. Also, to uncover a deeper understanding if the molecular and immunological mechanisms associated with operational tolerance will uncover novel targets for therapeutic interventions, ultimately paving the way for personalized and minimally immunosuppressed liver transplant approaches.

• Unraveling Immunological Dysregulation and Genetic Factors in Psoriatic Arthritis (PsA) Scottsdale/Phoenix, Ariz.

  The purpose of this study is to evaluate the phenotype, stability, functionality, transcriptome and TCR repertoire of peripheral vs synovial Tregs from PsA patients and HCs. Additionally, to establish a HIS mouse model of PsA to evaluate autoimmune responses against the joint and tendon tissues, and to evaluate the potential of CD2-KO Tregs in protecting human joint and tendon cells from autoreactive immune responses in vivo.