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What is this?
A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

Study phase

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

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  1. The Role that Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia

    Rochester, MN

  2. Direct Anterior vs. Anterolateral Approach for Hip Arthroplasty After Femoral Neck Fracture in the Senior Population

    Rochester, MN

  3. Understanding Post-Traumatic Headache: Forward Translation of a Posttraumatic Headache Animal Model to Posttraumatic Headache in the Human

    Scottsdale/Phoenix, AZ

  4. Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

    Rochester, MN

  5. Phase I Trial of Sargramostim and Nivolumab for Metastatic Melanoma to the Lung

    Rochester, MN

  6. A Study of ALX148 With Azacitidine for Higher Risk Myelodysplastic Syndrome

    Rochester, MN

  7. A Study of the Effectiveness and Safety of Rivaroxaban on Venous Thromboembolic Risk in Patients Following Hospital Discharge

  8. Once-daily Oral VT-464 in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.

    Jacksonville, FL

  9. Nanopore Sequencing for Detecting Bacteria in Bile and Preventing Surgical Site Infections in Patients Undergoing Surgery for Benign or Malignant Pancreatic Tumors

    Rochester, MN

  10. Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil

    Rochester, MN

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