Clinical Trials

The OPTIMUM registry is a minimal risk observational study that uses a prospective cohort design to follow patients who have multivessel or left main coronary artery disease ("surgical anatomy" according to ACC/AHA Appropriateness Criteria for PCI12) and are deemed ineligible for coronary artery bypass surgery. It is anticipated that 20 sites will be selected to participate in the registry from a national network of leading centers across the United States with recognized expertise in both complex PCI and coronary artery bypass surgery. We will invite leading cardiac centers, as defined by US News and World reports rankings for heart care. ...

The purpose of this study is to screen for unique or characteristic circulating peptides, hormonal biomarkers and circulating mRNA in patients who have experienced spontaneous coronary artery dissection (SCAD).

The primary research hypothesis is that in the modern cardiac catheterization laboratory, where PCI procedural duration is relatively short and rates of intracoronary stenting and dual antiplatelet therapy use is high, lower ACT targets, as compared with higher ACT targets, will be associated with lower rates of bleeding while having similar rates of ischemic events.

This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment elevation. Safety will be assessed by evaluating the association of major adverse events (re-arrest, bleeding, pulmonary edema, hypotension, acute renal insufficiency, and pneumonia) with early coronary angiogram. Efficacy will be assessed by a composite endpoint of improved left ventricular regional and global function (both regional wall motion analysis and left ventricular ejection fraction) as measured by echocardiography prior to hospital discharge and favourable neurological function (Cerebral Performance Categories ...

The purpose of this study is to determine the sensitivity and specificity of the 15O-H2O PET myocardial perfusion imaging (MPI) study to detect coronary artery disease (CAD) using the truth-standard of invasive coronary angiogram (ICA) with fractional flow reserve (FFR) or coronary computed tomography angiogram (CCTA).

In the present study we aim at validating the computation of FFRangio values from the angiogram by comparing them to measured wire-based FFR values, in a larger scale and in a completely blinded manner. Investigation of a wide range of users in various conditions may strengthen the reliability of the FFRAngio measurements.

The purpose of this study is to look at a contrast-enhanced MR angiography method in comparison to current methods. The contrast-enhanced method can generate images with more spatial detail and can be used to view a much larger region of the patient’s body than is presently possible.

3D angiography (3DA) imaging is a valuable method for assessing cardiovascular anatomy prior to and following trans-catheter intervention.  Current 3DA contributes substantially to the overall patient radiation dose for these procedures.  The purpose of this work is to assess the clinical efficacy of reduced radiation dose 3DA.

The purpose of this study is to answer the question: “Does a short course of oral anticoagulation with a direct oral anticoagulant after transradial access for coronary angiography/left heart catheterization and/or percutaneous coronary intervention reduce the incidence of radial artery occlusion?” The hypothesis is that oral anticoagulation will reduce the incidence of radial artery occlusion at 30 days without a significant increase in the rate of clinically significant bleeding.

The purpose of this study is to establish a registry that will address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction) between ED (Emergency Department) arrival and diagnostic angiography in detail, by characterizing and following the ED and peri-ED use of advanced OAP (Oral Anti-Platelet) agents. In addition to exploring ED treatment patterns and success of both ischemic and bleeding risk stratification prior to definition of the coronary anatomy, data generated via the UPSTREAM registry will allow plausible attribution of ischemic and bleeding outcomes to pre-catheterization antiplatelet therapy in the management of NSTEMI. This registry further seeks ...

The purposes for this study are to determine the ability of volumetric dynamic 4D CTA compared to replace current single-phase CTA and eliminate venous contamination that can decrease scan accuracy. Additionally, we seek to estimate the ability of this new imaging technique (volumetric dynamic 4D CTA) to reduce the dose of intravenous iodine and radiation dose. 

The study is being done to compare radiation exposure between two standard-of-care methods of abdominal aortic aneurysm repair.

This study aims to perform a prospective analysis of patients undergoing fibrillation ablations and compare the validity of the electroanatomical registration with superimposed angiography. In addition, this study aims to compare and understand the relationship between the cardiac vessels.

Our purpose for this study is to help design a therapy plan that can decrease extra radiation exposure to your heart during radiotherapy. The therapy plan will use images obtained using a dual-source CT scanner

The objective of this study is to evaluate the image quality and radiation dose of a CT angiography protocol (CTA) using tube potential selection and weight-based method.