Clinical Trials

The purpose of this study is to assess the impact of sedation strategy on cognitive outcomes after left atrial appendage occlusion (LAAO) occlusion with the WATCHMAN FLX™ or AMULET device.

Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery. Air is the traditional method used to inflate the breathing tube cuff. Researchers wish to find if lidocaine works better than air to facilitate tolerance to the breathing tube (decreased coughing, sore throat, hoarseness). They also want to learn more about its effectiveness for this particular surgical intervention.

The purpose of this study is to assess the agreement and repeatability between TOF values obtained from ToFscan and TetraGraph.

The purpose of this study is to determine if anesthesia after concussion is associated with cognitive dysfunction, and if recent concussion is a patient safety risk in the perioperative period

The purpose of this study is to determine whether patients who receive sugammadex immediately after the removal of a surgical breathing tube will have a decrease in the incidence of postoperative residual paralysis and an associated decrease in the incidence of postoperative respiratory depression.

The overall objective of this study is to develop the tools and preliminary data to permit the evaluation of the proposed conceptual framework of how procedures requiring anesthesia affect child health. 

In this study, we are comparing the performance of children who did and did not receive anesthesia before their third birthday on tests of cognitive skills such as memory, attention and planning/organization

The purpose of this study is to compare a ventilation strategy using higher levels of positive end expiratory pressure and recruitment maneuvers to one using lower levels of positive end expiratory pressure without recruitment maneuvers in obese patients at an intermediate-to-high risk for post surgery respiratory complications.

The purpose of this study is to evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.

The purpose of this study is to determine if neurodevelopmental abnormalities in children exposed to anesthesia prior to age 3 are associated with specific changes in brain MRI.  Individuals who have already undergone detailed neuropsychological testing as part of an earlier study will be invited to return for brain imaging.

The purpose of this study is to compare intubating conditions at varying levels of rocuronium-induced neuromuscular blockade.

The purpose of this study is to determine measurement difference and variability of bispectral index (BIS) values when monitored in a bilateral frontal montage.

The aim of the study is to create a registry to prospectively collect pre-operative, during surgery and post-operative data, questionaries will assess (at baseline before the surgery, 3-4 weeks, and at 3-6 months) cognitive function, assessed with a Mini-mental State Examination (MMSE), PROMIS Fatigue 7a form, quality of life (QoL), assessed using the SF-12 questionnaire, quality of sleep assessed using PROMIS Sleep disturbance 7a form (1 week after surgery).

The purpose of this study is to compare two methods of postoperative pain management for patients who have undergone total knee replacement surgery.

The purpose of the study is to determine the feasibility of administration of high dose intravenous ascorbic acid in the operative and post-operative environments as well as sample size for a prospective, randomized, placebo controlled study.