Clinical Trials

The primary purpose of this study is to evaluate the effectiveness of Apraglutide (5 mg subcutaneously (SC), once weekly) in reducing the administered volume per week of PS from baseline, compared with placebo in adults with Short Bowel Syndrome and Intestinal Failure.

Short bowel syndrome is a malabsorptive condition characterized by extreme reduction in functional small intestinal length most commonly as a result of surgical resection due to mesenteric ischemia or Inflammatory Bowel Disease (IBD) although other etiologies are also present. 

This investigation constitutes an initial evaluation of the stoma occlusion device in humans with a mature permanent Brooke ileostomy. The overall objective of this study is to assess feasibility and initial operating characteristics of a novel stoma occlusion device. The study will recruit 20 patients for placement of the device into the mature Brooke ileostomy and subsequent 2 hour observation period. The device will remain in the ileostomy for up to 2 hours.

The purpose of this study is to assess the immediate outcomes associated with early closure of diverting loop ileostomy.  In addition, days to return to work will be calculated.