Clinical Trials

The purpose of this study is to compare the time needed to achieve ventilation with early insertion of supraglottic airway vs. standard of care with face mask ventilation.  This will involve patients with suspected difficult mask ventilation undergoing surgical procedure that requires administration of neuromuscular blockade agents intraoperatively. These surgical procedures include laparoscopic and robotic surgeries.

The purpose of this research is to study the natural history of "ventilator associated pneumonia" and its causes and treatments.

The primary purpose of this study is to measure the transpulmonary driving pressures of patients on airway pressure release ventilation (APRV) during a 1 hour period to assess how the lung responds to the mechanical breath profile of APRV with a time-controlled adaptive ventilation (TCAV) protocol.

The purpose of this study is to test the correspondence between Airway Driving Pressure (DPAW; defined as plateau pressure minus positive end-expiratory pressure) and transpulmonary driving pressure (DPTP)—the quotient of tidal volume and lung compliance (CL), in response to intra-abdominal hypertension and changes in positive end-expiratory pressure during laparoscopic and robotic surgical interventions requiring intra-abdominal insufflation.

The primary objective of this study is to identify the presence, intensity and distress of symptoms in patients receiving noninvasive ventilation in the ICU using a modified version the Edmonton Symptom Assessment Scale (ESAS).

The secondary objective is to describe the most frequent and most distressing symptoms experienced by patients receiving NIV in the ICU.

There are currently no devices approved in the United States for providing continuous, temporary, extracorporeal carbon dioxide removal (ECCO2R). Although such devices have approvals outside of the United States, there have been no pivotal randomized, controlled trials (RCT) that have scientifically validated the safety and efficacy of ECCO2R for any potential indication. A primary potential indication is for acute hypercapnic respiratory failure in patients experiencing an acute exacerbation of COPD.
This study is being conducted under an FDA approved IDE to establish the safety and efficacy of an investigational Class III medical device for FDA pre-market approval (PMA) via a ...

Severe acute respiratory failure requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure, high mortality, and functional impairment. The purpose of this study is to improve the outcomes of patients at high risk with early intervention using an electronic medical records checklist aimed at preventing the lung injury that commonly leads to organ failure.

The purpose of this study is to compare the percentage of time sedation depth is maintained within the target range, in absence of rescue sedation, as assessed according to the RASS scale, in isoflurane- vs propofol-treated patients.

The purpose of this study is to evaluate the effectiveness of a seven-day slow-tempo music intervention on the primary outcome of delirium/coma free days among mechanically ventilated, critically ill older adults.

Critically ill older adults admitted to the intensive care unit (ICU) are at a higher risk to develop delirium, which predisposes them to longer lengths of ICU and hospital stay, increased in-patient mortality, and higher risk of new acquired cognitive impairment and dementia. Music listening is a non-pharmacological intervention that holds potential to decrease ICU delirium.

The purpose of this study is to evaluate whether or not the diaphragm and abdominal muscle thickness determine the duration of mechanical ventilation in adult critically ill patients.

This study aims to assess the experiences of lesbian, gay, bisexual, transgender, and/or queer (LGBTQ) patients who have been admitted to the intensive care unit and to identify any unique stressors or heteronormative biases that are faced by LGBTQ patients in the course of an admission to the ICU. Most patients who are admitted to the ICU require a surrogate decision maker to communicate on their behalf at some point in their stay. However there is wide variety in legal standards for who has the authority to act as a surrogate decision maker if the patient has not designated one already. Fifteen ...

The purpose of this trial is to compare the effectiveness of psychological support based on positive suggestions (PSBPS) vs. usual care on mental health morbidity and cognitive function in survivors of critical illness.

The objective of this project is to refine and test a behavioral intervention to be administered in parallel with medical treatment in the ICU.

The purpose of this study is to evaluate the use of a non-invasive bedside echocardiography to assess the effect of mechanical ventilation (invasive and non-invasive) on the function of the heart.

The purpose of this study is to compare a strategy using high PEEP (10 cmH2O) with recruitment maneuvers versus low PEEP (5 cmH2O) without recruitment maneuvers, during thoracic surgery under standardized one lung ventilation with low VT (5 mL/kg predicted body weight – PBW) in adults.

The purpose of this study is to evaluate the effect of a pre-ICU admission simulation session on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.