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A Study to Evaluate Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
Rochester, MN
The purpose of this study is to investigate how abrupt loss of ovarian hormones following bilateral oophorectomy affects overall aging, physical performance, and cognitive function, including the risk for Alzheimer’s disease in women who had this procedure performed prior to natural menopause for benign conditions.
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A Study to Understand Sex-Specific Effects of Endocrine Disruption on Physical Activity
Rochester, MN
The purpose of this study is to determine whether a history of premenopausal bilateral salpingo-oophorectomy (BSO, removal of ovaries and fallopian tubes) is associated with decreased performance on objective measures of physical activity.
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WISP (Women Choosing Surgical Prevention)
Rochester, MN
This phase II trial studies how well surgery works in preventing ovarian cancer in patients with genetic mutations at risk of ovarian cancer. Risk reducing salpingo oophorectomy (RRSO) is surgery to remove the fallopian tubes and ovaries at the same time. Interval salpingectomy with delayed oophorectomy (ISDO) is surgery to remove the fallopian tubes. It is not known whether ISDO works better than RRSO at lowering risk of ovarian cancer and improving the sexual function and psychosocial well-being in patients with genetic mutation.
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A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy
Rochester, MN
The purpose of this study is to compare the cardiovascular function in young women (<46 years)="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" oral="" dose)="" or="" titrated="" estradiol="" dosing="" to="" achieve="" average="" premenopausal="" estradiol="" level="" (80-120="" pg/ml),="" to="" characterize="" the="" relationship="" between="" the="" serum="" estradiol="" level="" and="" cardiovascular="" function="" in="" young="" women=""><46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent ... years)="" on="" estradiol="" replacement="" after="" bilateral="" oophorectomy,="" and="" to="" compare="" the="" body="" composition="" in="" young="" women="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" ...="">
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Use of Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy and Risk of Malignancy in Genetic Mutation Carriers
Rochester, MN
The purpose of this study is to determine if an increase risk of malignancy occurs in these patients if they use hormonal replacement therapies after a risk reducing salpingo-oophorectomy
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A Study to Evaluate the Impact of Menopause on Cardiac Stiffness Acquired with Magnetic Resonance Elastography
Rochester, MN
The purpose of this study is to evaluate the effects of menopause transition on myocardial stiffness in healthy female subjects without a history of heart disease who are expected to be close to the average age of menopause transition (~51 years), in the 48-53 year age range. All eligible subjects will undergo two study visits that will include a cardiac MRI/MRE exam, echocardiography imaging and blood test.
The purpose of this aim is to characterize the relationship between the serum estradiol level and myocardial stiffness changes in young women (<46) on estradiol replacement therapy after bilateral oophorectomy. Subjects will be ...