Clinical Trials

The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more physically active in their daily lives.

The purpose of this study is to compare resting blood pressure, heart rate, and quality of life outcomes in cardiac rehab patients with canine involvement versus traditional cardiac rehab therapy alone.

The purpose of this study is to evaluate the impact of interventions on important CV biomarkers to provide valuable information on the mechanism linking depression and anxiety to cardiac prognosis resulting in improved quality of life and diagnosis.

While pulmonary rehabilitation provides benefits to people with COPD, only 1.5% have access to pulmonary rehabilitation each year. The main barriers are related to travel and transportation. This protocol will evaluate the effect of a home-based rehabilitation system on quality of life and steps. The system allows for monitoring by a health care system. A health coach will review the data and provide coaching to facilitate behavioral change and self-efficacy. Patients will be randomized to 1 of 2 groups.

The primary aim of this study is to assess colon and rectal surgery patient perceptions of physical fitness, willingness to participate in a prehabilitation program, access to cardiovascular and strength training equipment, and impact of the COVID19 pandemic on fitness and health. The secondary aim is to evaluate if patient’s perceptions of physical fitness correlate with baseline demographic and health variables and outcomes following surgery.

The primary purpose of this study is to determine if a 3-week interdisciplinary chronic pain self-management program is effective in improving 1) patient-reported measures of pain, function, quality of life mood and sleep; 2) physical capacity; 3) performance as measured by change in activity counts; and 4) sleep efficiency as measured by actigraphy.  Activity and patient reported outcomes as well as measures of performance will all be collected in patients before during and after participation in the 3-week interdisciplinray pain program and subsequently analyzed to determine how much each of these improve over the course of treatment and ...

The purpose of this study is to create a computerized multidimensional assessment that can quickly assign hospitalized patients to ability-matched rehabilitation care plans, in three essential areas; Mobility, Daily Activity, and Applied Cognition (ability to think/problem solve).

The purpose of this study is to assess two accelerated rehabilitation programs for use with the InSpace™ device in the treatment of full thickness Massive, Irreparable Rotator Cuff Tears (MIRCTs) performed during an arthroscopic procedure.  

The purpose of the study is to learn more about adolescent and young adults' experience with chronic pain. In particular, we are studying factors which lead to pain-associated disability and factors which predict decreased disability during and after participation in a three-week intensive treatment program. In addition to gathering information from the young people with chronic pain, parents are also asked to give their perspective.

The purpose of this study is to evaluate a tele-rehabilitation service directed at treating upper limb weakness due to stroke to see if it is feasible to provide at Mayo Clinic, and also to assess if the stroke patients and clinicians are satisfied with the process.

The overall goal of this project is to reduce risk of second anterior cruciate ligament (ACL) injury in vulnerable populations (active athletes between 14 = 24 years old) through the identification of relative injury risk groups based on subject-specific movement patterns prior to second injury, as well as through the determination of effect for differential rehabilitation protocols following initial ACL reconstruction and prior to return to sport. As nearly one-third of athletes who have a primary ACL injury and return to sport will experience a secondary injury, results from the proposed work will allow us to prospectively identify high risk ...

The purpose of this research study is to examine how certain genes and lifetime and ongoing stress may impact rehabilitation and recovery after stroke.

This is a randomized, double-blind, placebo-controlled parallel group outpatient study that will utilize standard stroke rehabilitation outcome measures, as well as fMRI techniques in a subset of subjects, to evaluate the effect of HT-3951 on motor recovery and behavior in medically stable subjects following ischemic stroke.

The purpose of this study is to conduct a comprehensive clinical and biomechanical screening of high school, collegiate-level, recreational, and Olympic/professional-level athletes with the goal of identifying individual functional and performance deficits that lead to future injury.

The purpose of this study is to understand the lived experience of physical therapy rehabilitation for older adults after being seriously injured by a fall, requiring hospitalization.

The purpose of this study is to identify Arabic interpreters’ perspective on their successes, challenges, barriers and/or difficulties with interpreting words, concepts, and health beliefs within the context of the outpatient PPT (Pediatric Physical Therapy) setting. Also, to discover families’ expectations for PPT episodes, perceptions of care, and exercise-related health beliefs of Arabic speaking Middle Eastern pediatric patients and their families who require interpreter services.

The primary purpose of this study is to evaluate the whether or not a preoperative Short Grit Scale Score is associated with maximum distance walked following total knee or hip arthroplasty.

Cardiopulmonary rehabilitation (CP rehab) with an exercise component is important in the care from many people with heart or lung disease. Measuring the benefits of CP rehab (i.e., measuring ‘how well CP rehab works’) depends upon having tests or ‘tools’ that can very well detect positive changes in physical and clinical function. One such tool is maximal cardiopulmonary exercise testing (CPET). This is the gold standard for measuring exercise capacity. However, maximal CPET is expensive, has extensive set-up and space requirements, needs direct medical supervision, and involves interpretive complexity; these factors have limited the widespread use of maximal ...

The purpose of this study is to raise awareness of and actively address patient physical mobilization needs throughout admission to the ICU, and assess the impact this has on patient quality of care.

The purpose of this study is to compare the effectiveness of combination therapy with antidepressants (AD), fear avoidance rehabilitation (EFAR) AD+EFAR vs. each treatment alone to improve pain, self-reported function, depression, and anxiety in patients with chronic low back pain and high negative affect.

The goal of this study is to provide longitudinal data on the efficacy of cognitive behavior- based interdisciplinary pain rehabilitation treatment combined with physical therapy, occupational therapy, and substance use education for patients with chronic pain with various levels of risk for opioid abuse.  

The overall objective of this project is to investigate the effects of timing of surgery (early vs. delayed) and timing of post-op rehabilitation (early vs. delayed) for the treatment of military personnel and civilians that have sustained a Multiple Ligament Knee Injury (MLKI).

The purpose of this study is the evaluation of new tools and strategies for the clinical assessment, management, and rehabilitation of concussions.

The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.

The purpose of this study is to determine whether an exercise program reduces fatigue and improves physical activity in thyroid cancer patients, and to determine the effect of a home-based program compared to a center- based program.

The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

The proposed study is intended to inform the hypotheses that (1) regular dosing of exoskeleton walking will provide health benefits to non-ambulatory and poorly-ambulatory individuals with SCI, including decreased pain and spasticity, improvements in bowel and bladder function, decreased body-mass index (BMI), enhanced well-being; (2) regular dosing of exoskeleton walking will facilitate neurological or functional recovery in some individuals with SCI, particularly those with incomplete injuries; and (3) the level of mobility enabled by a lower limb exoskeleton is commensurate with the walking speeds, distances, and surfaces required for community ambulation.

The purpose of this study is to evaluate long-term patient outcomes and satisfaction with our comprehensive pelvic floor rehabilitation program at 3-months, 6-months and 12-months following therapy completion.