Clinical Trials

The purpose of this study is to compare the effectiveness and safety of an automated insulin delivery (AID) system using a model predictive control (MPC) algorithm versus Sensor-Augmented Pump/Predictive Low Glucose Suspend (SAP/PLGS) therapy with different stress assessments over a 4-week period.

The purpose of the current research study is to understand how physiological measures, cognitive performance, and self-report of perceived stress change after acute stress and how different features of a relaxation room promote recovery after stress.

This research project’s vision is to develop a technology to predict burnout in RNs by combining workplace, psychological, and physiological factors, and exploring the barriers to adopting such a technology.

Aim 1 is to create a unique, open-access, de-identified dataset that transforms the science of burnout internationally and informs the interaction of continuous physiological measures (measured from smart watches) and repeated psychological and work-related factors for predicting burnout in RNs at Mayo Clinic’s Florida and Rochester sites.

Aim 2 is to develop an analytical framework combining probabilistic graphical models (PGMs) and multitask learning (MTL) to derive interpretable predictions of ...

The basis of this study is to strengthen and provide clinical validation for The Oxygen Plan Stress Test and resulting Stress Number® and Stress Number® Breakdown’

The purpose of this study it so gather preliminary data regarding the impact a relaxation device has on stress level.

The purpose of this study is to assess the effectiveness of an intervention program promoting emotional and cognitive health to modify high levels of perceived daily stress and quality of life in the patients of an executive health program.

The purpose of this study is to assess the feasibility and acceptability of the use of a wearable health monitor (Health Tag) for measuring stress among family caregivers (FCGs) of palliative care patients.

The purpose of this study is to evaluate the outcomes of a comprehensive wellness program including Stress Management and Resiliency Training (SMART), physical fitness education, and nutrition education in Student Registered Nurse Anesthetists (SRNAs) in Mayo’s Nurse Anesthesia Graduate Programs.

The purpose of this study is to ascertain the effects of the Authentic Connections intervention among nurse leaders who are mothers at Mayo Clinic Rochester in comparison to a control group. Outcomes that will be measured include: psychological distress, depression, self-compassion, parenting stress, burnout, and feasibility measures.

The investigators are doing this research study to find out if the Stress Management and Resiliency Training (SMART) therapy will help subjects with their major depression treatment.

The aim of this study is to develop a feasible, acceptable, and sustainable comprehensive cancer distress management program that is tailored to the unique needs of cancer patient survivors.

The primary purpose of this study is to compare outcomes of depressive symptoms (PHQ-9 and HAM-D) over 6 months following an eight-week program of SMART-D therapy + treatment as usual versus treatment as usual for patients with major depression in partial-to full-remission.

The purpose of this study is to assess baseline anxiety experienced by children and their parents/guardians associated with outpatient visits in pediatric oncology.  Assess coping mechanisms used by children and their parents/guardians to alleviate the anxiety associated with outpatient visits in pediatric oncology.

The purpose of this study is to track the treatment burden experienced by patients living with Type 2 Diabetes Mellitus (T2DM) experience as they work to manage their illness in the context of social distancing measures. 

To promote social distancing during the COVID-19 pandemic, health care institutions around the world have rapidly expanded their use of telemedicine to replace in-office appointments where possible.1 For patients with diabetes, who spend considerable time and energy engaging with various components of the health care system,2,3 this unexpected and abrupt transition to virtual health care may signal significant changes to ...

This study seeks to find out if Sex SMART (Stress Management And Resiliency Training for Sexuality), using mindfulness techniques in a woman's everyday routine, is a feasible and effective treatment to increase sexual function in women who report sexual distress compared to those receiving the current standard of care.

The purpose of this study is to measure, rank, and categorize the subject sample of depression, stress, resilience, and happiness scores using quantitive surgeys. This research aims to learn how a Three Good Things (3GT) journaling activity affects a subject's symptoms of stress, depression, reslieince, and happiness.  The data will allow the project team to gain an in-depth understanding of the impact of the use of resilience strategies from a patient's perspective. This project aims to review if there is a correlation between stress, depression, resiliency, and happiness scores to the use of Positive Psychology.

The purpose of this study is to see how usefull will the Heart SMART program be in moderate or high stress patients who are referred to the Women's Heart and Preventive Cardiology clinics at Mayo Clinic.

The purpose of this study is to assess the effect of Mayo Clinic’s Resilience Training Program among healthcare employees and members of an employee-based wellness center.

The purpose of this study is to determine the usefulness and effectiveness of Muse, a brain sensing headband intervention, to affect quality of life, stress, fatigue and sleep in newly diagnosed breast cancer patients who are undergoing surgical treatment.

The purpose of this study is to evaluate the feasibility of a resiliency program to provide an effective and sustainable solution to several important problems experienced by medical professionals.

This study examines Stress Management and Resilience Training (SMART) for family caregivers (FCG) of patients receiving chemotherapy for advanced cancer to potentially help with the stressful aspects of providing care. All participants will receive the SMART intervention.

The purpose of this study is to improve dignity and life quality for patients and their families, and to effectively counter burnout and vulnerability to adverse mental experience in the highly stressful environment of end-of-life care.

The purpose of this study is to test the effectiveness of cancer stress management (CBCSM) as a clinical service at Mayo Clinic.

The FMD-ICI study will utilize animal and human data that finds that fasting may promote survival mechanisms and stress resiliency. The study aims to assess the impact that a restrictive calorie diet, mostly of fat and complex carbohydrates, mimicking fasting and increasing resiliency will have in protecting patients from the adverse effects of all advanced cancer treatments which require immunotherapy. By managing the adverse side effects of ICI treatments in select cancer patients, the study will assess the effect of immunotherapy plus the Xentigen fasting mimicking diet on adverse events rates, including immune-mediated colitis. Patients will be supplied with all their dietary requirements for 4 ...

The purpose of this study is to evaluate the effectiveness of a mindfulness-based intervention (MBI) on subjective reports of wellness including emotional, physical, functional, and social domains during radiotherapy for the treatment of cancer.

The purpose of this study is to examine the effects of a health coaching intervention on the stress and burden of caregivers of patients awaiting heart or lung transplant.

Hypotheses:  Caregivers will have traits and behaviors pre-transplant that will predict caregiver readiness, quality of life, and transplant recipient outcomes. Specifically, thoracic pre-transplant caregivers report stress, symptoms of anxiety or depression, and perceive high caregiver burden. These factors may be amenable to pre-transplant intervention to improve overall patient and caregiver outcomes.

Aims, purpose, or objectives:  We will conduct a pilot trial to test whether caregivers of heart and lung transplant candidates ...