Infectious Diseases Research

Below are current clinical trials.

271 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. SER-109 Versus Placebo to Prevent Recurrent Clostridium Difficile Infection (RCDI)

   Rochester, Minn.

   The study will involve administering the study drug as a single dose of study drug or placebo. This study is designed to demonstrate the superiority of the experimental drug versus placebo in adult patients with recurrent CDI.

2. A Study to Evaluate the Immune Response of Healthy Individuals for the 2017-2018 Seasonal Flu Vaccine

   Rochester, Minn.

   The purpose of this study is to evaluate the immune response of healthy individuals to the 2017-2018 seasonal flu vaccine.

3. Teleworking in the Health Care Industry Due to COVID-19

   Rochester, Minn.

   The purpose of this study is to understand how transitioning to telework due to COVID-19 impacts employee satisfaction in one health care facility and how select non-clinical employees describe their experiences after transitioning from an in-person work environment to telework.

4. Recurrent Clostridium Difficile vs Post Infectious IBS: A Prospective Study

   Rochester, Minn.

   The purpose of this study is to assess patients suspected of recurrent C. difficile disease (rCDI) and using a combination of clinical and laboratory markers to determine disease versus post infectious irritable bowel syndrome (IBS) with C. difficile colonization.

5. Alcoholic Hepatitis: A Multicenter, Observational Study by the TREAT Consortium

   Rochester, Minn., La Crosse, Wis., Albert Lea, Minn.

   To conduct a prospective, multicenter, observational study of patients with well-characterized alcoholic hepatitis (AH) and frequency matched individuals (by age, gender, and race) with comparable history of alcohol consumption but no clinical evidence of liver disease (controls). At the end of the study, a robust clinical information, central bio-repository will be developed from both cases and controls.

6. A Study to Evaluate Clazakizumab in Patients with Life-threatening COVID-19 Infection (Enrolling by Invitation Only)

   Scottsdale/Phoenix, Ariz.

   The primary purpose of this study is to assess the safety of clazakizumab treatment in COVID-19 infected patients with respiratory failure due to hyperinflammation related to cytokine storm.

7. PC945 Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and tolerability of PC945 for the prevention of fungal aspergillus infections in the lung in patients who have received a lung transplant.

8. A Study to Evaluate MesilatE for Treating Hospitalized Patients with COVID-19 (Enrolling by Invitation Only)

   Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The primary purpose of this study is to determine if the reduction in TMPRSS2 activity via direct inhibition with Camostat mesilate combined with standard of care (SOC) treatment will increase the proportion of patients alive and free from respiratory failure at Day 28 in SARS-CoV-2 as compared to SOC treatment with placebo.

    

    

9. Efficacy and Safety of COVID-19 Vaccine in Cancer Patients

   Jacksonville, Fla.

   We hypothesize that cancer patients on cytotoxic chemotherapy which affect immune response may not mount adequate immune response to COVID-19 vaccines.

   Aims, purpose, or objectives:

   1. To determine the antibody response to COVID-19 vaccine after vaccination.
   2. To assess the adverse events of COVID-19 vaccines in cancer patients.
   3. To determine the incidence and severity of COVID-19 infection after the vaccination.

10. A Study to Collect Tissue, Fluids, Blood and/or Fungal Samples in Patients with Pulmonary and Extrapulmonary Coccidioidomycosis

    Scottsdale/Phoenix, Ariz.

    The purpose of this study is to create a biorepository of tissue, fluid and fungal specimens for future studies.