Infectious Diseases Research

Below are current clinical trials.

271 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD3)

   Jacksonville, Fla.

   This is a prospective, multicenter, randomized, double-blinded, placebo-controlled Phase 3 study of a microbiota suspension of intestinal microbes. Patients who have had at least two recurrences after a primary episode and have completed at least two rounds of standard-of-care oral antibiotic therapy or have had at least two episodes of severe CDI resulting in hospitalization within the last year may be eligible for the study. Subjects who are deemed failures following the blinded treatment per the pre-specified treatment failure definition may elect to receive an unblinded RBX2660 enema.

2. Silver-impregnated Suprapubic Catheters (SPC) in Urogynecology

   Rochester, Minn.

   Urinary catheters are used routinely in the postoperative care of urogynecology patients after surgery involving the genitourinary tract. However, Urinary tract infections(UTI) associated with indwelling catheter is the second leading cause of nosocomial infections. 20% of hospital acquired bacteremia arise from UTI with an associated mortality of 10%.

   There are many different types of catheters available for use. Standard indwelling catheters are made from a variety of materials including polyvinyl chlorine, plastic, plain latex, polytetrafluoroethylene, silicone elastomer, pure silicone hydrogel and polymer hydromer. Specialized catheters have been developed with the aim of reducing infection. Strategies generally involved coating the inner, outer or both surfaces of the catheter with antimicrobial materials. These materials can be antibiotic or antiseptic with the most common antiseptic material used being silver. Silver ions are bactericidal, are used safely when applied topically to humans and used in controlling infections.

   Previous studies comparing UTI rates in transurethral catheters have reported a significant reduction of UTI rate in silver-alloy catheters with a range of 5-12% compared to standard catheters with a range of 7-50%. There are no studies comparing the UTI rate in silver-alloy supra-pubic catheters to standard supra-pubic catheters. The investigators hypothesize that this study will show a statistically significant decrease in UTI rate among the individuals with a silver-alloy suprapubic catheter compared to the standard silver-alloy catheter.

3. A Study to Evaluate the Safety of the SARS-CoV-2 Vaccination in Patients Waitlisted for Solid Organ Transplantation

   Jacksonville, Fla.

   The purpose of this study is to determine the safety of the SARS-CoV-2 vaccination in patients listed for solid organ transplantation, including heart, lung, liver, kidney, and pancreas.

    

4. Mucosal and Microbiota Changes During Acute Campylobacteriosis

   Rochester, Minn.

   Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to understand if changes in gut bacteria and gut mucosal lining during an acute infection can help identify individuals who might be at risk for developing problems in the future.

5. COVID in the Community (Enrolling by Invitation Only)

   Rochester, Minn.

   Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in 2019 in Wuhan, China, and has since spread globally resulting in over 1 million confirmed cases in the US and 81,000 deaths to date. While the majority of cases result in mild symptoms, some progress to pneumonia and multi-organ failure, challenging our hospital capacity and available medical staff. Current estimates of confirmed COVID-19 cases miss those who have recovered from infection prior to widespread testing, those with mild or no symptoms, and those with symptoms who have not been tested due to limited availability of testing.  Thus, the true prevalence of COVID-19 infections in the US, Minnesota, and our surrounding community is unknown.  Antibodies to SARS-CoV-2 in the blood indicate that someone has been infected with the virus and developed an immune response.  Whether or not these individuals are protected from re-infection and how long this protection (if it exists) lasts are still unknown.

   Further, a number of persons are at higher risk of infection compared to the general population due to greater exposure to COVID-19.  In particular, first responders, persons working in long term care facilities that have had outbreaks of COVID-19, and day care providers.  Understanding rates of asymptomatic infections, rates of seroconversion, and risk of re-infection in these groups will be critical to understanding protective immunity.  In addition, this information will help inform public health measures to better isolate and prevent spread of COVID-19 in these settings in the future.

   To address these questions, we propose two surveillance studies of SARS-CoV-2 in the general population and high risk settings to estimate the extent of SARS-CoV-2 infections in our surrounding community.  We propose to use CLIA approved tests to identify serum antibodies to SARS-CoV-2 to identify past infection.

6. A Study to Generate Algorithms for Early Prediction of Aggressive Progression and Hospitalization in Patients Diagnosed with SARS-CoV-2/COVID-19 Infection

   Rochester, Minn.

   The purpose of this study is to observe participants who have tested positive for COVID-19 using Current Health AI to learn about the disease.

7. Health Coaching Post COVID

   Rochester, Minn.

   The purpose of this study is to examine whether health coaching provides added benefit to usual care for patients with post COVID syndrome. 

8. Continuous Glucose Monitor (CGM) Use in COVID-19 Patients

   Jacksonville, Fla.

   The purpose of this research is to determine if CGM (continuous glucose monitors) used in the hospital in patients with COVID-19 and diabetes treated with insulin will be as accurate as POC (point of care) glucose monitors. Also if found to be accurate, CGM reading data will be used together with POC glucometers to dose insulin therapy.

    

9. A Study to Evaluate the Safety and Tolerability of Rebiotix RBX2660 (microbiota suspension) in Subjects with Recurrent Clostridium difficile Infection

   Rochester, Minn.

   To assess the safety and tolerability of RBX2660 in subjects with recurrent CDI who have had prior recurrent CDI that was resolved with antibiotic treatment.

10. Cellular Senescence and COVID-19 Long-Hauler Syndrome

    Rochester, Minn.

    The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated.