Overview

The mission of Mayo Clinic's Division of Clinical Trials and Biostatistics, which is part of the Department of Quantitative Health Sciences, is to provide high-value analytical collaborations and research services to Mayo investigators with the overall goal of improving human health. The division accomplishes this by providing statistical support for thousands of active projects through collaboration with investigators both inside and outside of Mayo Clinic. These can cover a wide range of disciplines including cancer, Alzheimer's disease, respiratory specialities, cardiology, neurology, radiology, surgery, anesthesiology, nursing, and laboratory medicine and pathology.

Division staff members develop, maintain and promote state-of-the-art designs and analytical methods expertise and are active in multiple initiatives surrounding study design, data acquisition, data management, analyses and interpretation. Additionally, they contribute to many specialized research areas including:

• Basic science research.
• Clinical trials.
• Population health.
• Translational science.

The Division of Clinical Trials and Biostatistics is composed of 25 doctoral-level statisticians, 74 biostatisticians and 120 statistical programmers, with members based at all three Mayo Clinic campuses (Minnesota, Arizona and Florida). The division's unique collaboration model emphasizes the importance of disease-area knowledge in the design and analysis of research studies by embedding a dedicated statistical team into the research groups they support. This highly effective model has led to the division's successes in obtaining and supporting several large, multiyear federal grants including but not limited to:

• The secondary use of electronic medical records for surgical complication surveillance.
• Understanding the connection between traumatic brain injury and Alzheimer's disease.
• Mechanisms of low frequency EEG for focal epilepsy.
• CORE Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA).
• Mayo's Alzheimer's Disease Research Center.
• Frontiers in Congenital Disorders of Glycosylation.
• Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease.

The Division of Clinical Trials and Biostatistics also serves as the statistics and data coordinating center to support investigator-initiated, multicenter cancer research programs, including:

• Academic and Community Cancer Research United (ACCRU) network.
• Alliance for Clinical Trials in Oncology.
• Alliance Foundation Trials.
• Cancer Prevention Network.
• Early Cancer Therapeutics Group.
• Six large international clinical trial databases (SHARE).
• Specialized Programs of Research Excellence (SPORE) grants.

Division of Clinical Trials and Biostatistics faculty and staff are internationally renowned experts in many different statistical methodologies and disciplines, including the design and analysis of clinical trials, advanced survival analysis methodology, categorical data analysis, risk modeling, patient-reported outcomes, quality of life, Bayesian modeling, sampling theory, quality control, and causal inference. They serve on national steering committees and professional organizations and actively participate in national initiatives that have major impact on research directions in their respective areas of expertise.

Division leadership

Chaired by Jennifer Le-Rademacher, Ph.D., the leadership team in the Division of Clinical Trials and Biostatistics guides research operations, services and support.