Faculty

Frank V. Brozovich, M.D., Ph.D.

Location

Rochester, Minnesota

Contact

Brozovich.Frank@mayo.edu Clinical Profile

SUMMARY

It's unclear how changes in the regulation of smooth muscle contractile proteins contribute to cardiovascular disease. Through his research, Mayo Clinic cardiologist Frank V. Brozovich, M.D., Ph.D., aims to identify changes in protein structure and cell signaling that result in abnormal contractility. This work includes investigating pulmonary hypertension and heart failure with reduced or preserved ejection fraction.

Dr. Brozovich's research methods include transgenic, molecular biological, biochemical and biophysical experimental techniques.

Focus areas

  • Identifying alterations in signaling pathways that contribute to cardiovascular disease processes.
  • Investigating the regulation of cardiac and vascular contractility in both health and disease.
  • Defining protein-protein interactions and protein phosphorylation in the NO-PKG pathway that regulate signaling and control vascular tone.

Significance to patient care

The long-term objective of Dr. Brozovich's research is to identify new targets for rational drug design to treat cardiovascular conditions.

PROFESSIONAL DETAILS

Primary Appointment

  1. Consultant, Division of Comprehensive Cardiology, Department of Cardiovascular Medicine
  2. Chair for Education, Division of Comprehensive Cardiology, Department of Cardiovascular Medicine
  3. Director, Cardiac Education Clinic, Division of Comprehensive Cardiology, Department of Cardiovascular Medicine
  4. Director, Residency Education Clinic, Division of Comprehensive Cardiology, Department of Cardiovascular Medicine

Joint Appointment

  1. Consultant, Department of Physiology & Biomedical Engineering
  2. Consultant, Department of Biochemistry and Molecular Biology

Academic Rank

  1. Professor of Medicine
  2. Professor of Physiology

EDUCATION

  1. Clinical Fellowship Department of Cardiology, Graduate Hospital, University of Pennsylvania
  2. Chief Medical Resident Department of Medicine, Brockton/West Roxbury Veterans Administration Medical Center, Brockton, MA, Harvard Medical School
  3. Internship - Internal Medicine Department of Medicine, Beth Israel Hospital, Harvard Medical School
  4. Postdoctoral Research Fellowship Cardiovascular Division, Department of Medicine, Beth Israel Hospital, Harvard Medical School
  5. Resident - Internal Medicine Department of Medicine, Beth Israel Hospital, Harvard Medical School
  6. Predoctoral Research Fellow Department of Physiology and Biophysics, University of Washington, Seattle
  7. MD/PhD University of Washington, Seattle
  8. Predoctoral Research Fellow Department of Bioengineering, University of Washington, Seattle
  9. MSE University of Washington, Seattle
  10. BSE University of Washington, Seattle

Clinical Studies

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Publications

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Related links

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BIO-00093642

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