SUMMARY
Laura J. Lambert, Ph.D., is a biomedical scientist who specializes in creating and studying genetically engineered preclinical models of patient alleles and understanding the role of genetic variants in disease. Her broad research interests include repurposing drugs, discovering novel therapeutics and advancing genetic therapies.
Dr. Lambert has extensive experience creating, characterizing and treating patient-specific models of human disease. She also uses gene therapy and other therapeutic approaches for rare genetic conditions. These include exon skipping, ribozymes, CRISPRa and CRISPRi, prime editing, and base editing.
Focus areas
- Genome editing.
- CRISPR and gene replacement therapy.
- Nonviral delivery vectors.
- Patient-specific and patient-derived precision modeling.
- N=1 drug repurposing.
Significance to patient care
Dr. Lambert's research program works to improve care for people with rare diseases by making it easier to diagnose them, using laboratory research to understand these diseases better and turning personalized treatments into practical medical solutions.
Professional highlights
- Researcher, Minnesota Rare Disease Advisory Council, 2024-present.
- Co-investigator, Minnesota Partnership for Biotechnology and Medical Genomics, 2023-present.
- Director, Functional Omics Resource, Mayo Clinic, 2022-present.