Jaeyun Sung, Ph.D.

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SUMMARY

Mayo Clinic researcher Jaeyun Sung, Ph.D., is a computational biologist specializing in precision medicine. Dr. Sung uses artificial intelligence, machine learning and multi-omics systems biology to identify actionable biomarkers and develop targeted diagnostic and therapeutic strategies. By integrating large-scale biological data with advanced computational methods, Dr. Sung's laboratory bridges bench science and clinical application to drive innovation in oncology as well as autoimmune and inflammatory diseases. He aims to refine diagnostic precision, personalize treatments and advance data-driven approaches to improve patient outcomes.

Focus areas

• Algorithm-based biomarkers for precision health. Dr. Sung develops interpretable machine learning models to extract clinically relevant biomarkers from multi-omics data, enabling more-precise diagnostics and targeted interventions.
• Integrative multi-omics in microbiome science. Dr. Sung's lab uses network modeling and multi-omics analyses to characterize complex biological interactions. This research uncovers key mechanisms that drive health and disease.
• Systems-level investigation of autoimmune inflammatory disorders. Dr. Sung's research team integrates transcriptomic, proteomic and metabolomic data. This helps find molecular signatures in conditions such as rheumatoid arthritis and giant cell arteritis, informing new therapeutic strategies.
• Microbiome-driven therapeutic development. Using predictive modeling and ecological resilience frameworks, Dr. Sung's team designs microbiome-informed therapies and novel interventions for complex diseases.

Significance to patient care

Dr. Sung's research helps improve patient care in several ways:

• Precision medicine. Dr. Sung creates computer tools to find substances in people's bodies called biomarkers. These biomarkers can help healthcare professionals identify diseases more accurately and create personalized treatments. Dr. Sung is especially interested in biomarkers for patients with autoimmune and inflammatory diseases.
• Gut microbiome. Experts call the bacteria, viruses and fungi that live in each person's gut the gut microbiome. Dr. Sung studies the gut microbiome to predict patient health, create ways to make the gut microbiome healthier and find better treatments.
• Translational impact. Dr. Sung works with other healthcare professionals to use what he finds in patient care, speeding up the process from lab research to real-world treatments at Mayo Clinic.