Xue Wang, Ph.D.

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SUMMARY

Mayo Clinic health sciences researcher Xue Wang, Ph.D., applies and develops computational tools to understand patient and clinical datasets. Dr. Wang primarily focuses on neurodegenerative diseases and cancer to identify changes in genes and pathways in these diseases.

Focus areas

• Gene and pathway changes. Dr. Wang works to identify perturbed genes and pathways in patients with diseases and conditions, including Alzheimer's disease, progressive supranuclear palsy and breast cancer. To do this, she analyzes next-generation sequencing data — for example, bulk-tissue transcriptome and single-cell or nucleus RNA-seq analyses — from healthy donors and donors with one of the diseases in question.
• Cell signaling. She develops bioinformatic tools to deconvolute cell type-specific signals from bulk-tissue signals.
• RNA-seq therapeutics. Dr. Wang is developing a general computational platform to design RNA-seq therapeutics such as antisense oligonucleotides.

Significance to patient care

Dr. Wang's work using patients' transcriptome data helps identify risk factor genes and protective genes in Alzheimer's disease and progressive supranuclear palsy. By creating a computational platform for RNA-seq therapeutics design, Dr. Wang aims to advance the development of new treatments.