Targeting mechanisms of cellular damage to promote tissue regeneration
Abhishek Chandra, Ph.D., M.S., and his team at Mayo Clinic are exploring new treatment options for osteoporosis that target processes occurring within cells.
Overview
Mayo Clinic's Bone Injury and Repair Laboratory led by Abhishek Chandra, Ph.D., M.S., studies the causes of bone tissue deterioration and potential ways to promote tissue growth to treat osteoporosis.
Dr. Chandra and his team focus on the underlying causes of bone loss due to aging, radiation treatment for cancer (radiotherapy) and disease. The team studies the development of mesenchymal stem cells as they transition into final cell types in a process known as cell fate determination. The team studies how aging and health problems affect the development of cells and the bone marrow environment.
Dr. Chandra is particularly interested in developing treatments to improve bone quality in osteoporosis and resulting fractures caused by radiotherapy. In addition, his lab studies DNA damage and repair, programmed cell death called apoptosis, cellular senescence and regulation of pathways involved in age-related deterioration of bone cells.