Induction of Oral Tolerance During Early Life
Immunoglobulin A (in red) is found throughout the intestine.
As offspring grow during infancy, maternal components in breast milk that prevent antigen translocation become reduced and allow luminal antigens to translocate to the immune cells within the intestinal lamina propria. This process is vital for the induction of oral tolerance.
We are investigating the components supporting the induction of tolerance to oral antigens and the consequences of preventing antigen translocation during this time.
Funding source: National Institute of Diabetes and Digestive and Kidney Diseases R01 DK134366.