Overview

The Genome Function, Stability and Nuclear Organization in Cancer Laboratory at Mayo Clinic, led by Dr. Rodriguez-Bravo, studies cell and molecular biology mechanisms of genome organization and stability regulation in cancer. The lab has a special interest in transcription and genome integrity dysregulation in hormone-driven cancers such as prostate cancer.

Dr. Rodriguez-Bravo's research team is investigating the functional role of nuclear pore complex components called nucleoporins, as well as chromosomal instability causes and consequences in cancer. Her primary goal is to uncover fundamental molecular mechanisms to determine future therapeutic opportunities.

Using prostate cancer as a model, Dr. Rodriguez-Bravo's group applies a multidisciplinary approach involving genome editing and single-cell high-resolution microscopy, along with biochemical, transcriptomic, epigenetic and computational analysis to decipher novel molecules and mechanisms. Researchers in the lab use different types of experimental models, including cells, preclinical patient-derived models and patient tumor tissue samples covering different stages of the disease.

Dr. Rodriguez-Bravo works very closely with colleagues in Mayo Clinic's Department of Urology, sharing the common goal of discovery and innovation to unveil new therapeutic interventions for genitourinary malignancies.

Affiliations

Dr. Rodriguez-Bravo's lab is affiliated with these Mayo Clinic research groups:

• Department of Biochemistry and Molecular Biology
• Department of Urology
• Mayo Clinic Comprehensive Cancer Center — Research