Faculty

Nicholas F. LaRusso, M.D.

Publications

Jalan-Sakrikar N, Guicciardi ME, O'Hara SP, Azad A, LaRusso NF, Gores GJ, Huebert RC. Central role for cholangiocyte pathobiology in cholestatic liver diseases. Hepatology. 2024 Sep 9 Epub 2024 Sept 09
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McRae AN, Ticho AL, Liu Y, Ricardo-Silgado ML, Mangena NN, Jassir FF, Gonzalez-Izundegui D, Calderon G, Rohakhtar FR, Simon V, Li Y, Leggett C, Hurtado D, LaRusso N, Acosta AJ. Regulator of G-protein signaling expression in human intestinal enteroendocrine cells and potential role in satiety hormone secretion in health and obesity. EBioMedicine. 2024 Sep; 107:105283 Epub 2024 Aug 13
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Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Perez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF. Mitochondrial RNA cytosolic leakage drives the SASP. Res Sq. 2024 Aug 27
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Pant K, Richard S, Peixoto E, Baral S, Yang R, Ren Y, Masyuk TV, LaRusso NF, Gradilone SA. Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling. Hepatology. 2024 Aug 23 [Epub ahead of print]
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Juran BD, McCauley BM, Atkinson EJ, Schlicht EM, Bianchi JK, Vollenweider JM, Ye H, LaRusso NF, Gores GJ, Sun Z, Lazaridis KN. Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis-methylomics of cholestatic liver disease. Hepatol Commun. 2024 Aug 1; 8 (8) Epub 2024 July 18
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Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP. The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1. Gastroenterology. 2023 Jul; 165 (1):228-243.e2 Epub 2023 Apr 12
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Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP. The epigenetic reader, bromodomain containing 2, mediates cholangiocyte senescence via interaction with ets proto-oncogene 1. Gastroenterology. 2023 Jul; 165 (1):228-43.e2
Hochberg JT, Sohal A, Handa P, Maliken BD, Kim TK, Wang K, Gochanour E, Li Y, Rose JB, Nelson JE, Lindor KD, LaRusso NF, Kowdley KV. Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid. JHEP Rep. 2023 Jun; 5 (6):100729 Epub 2023 Mar 23
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Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, LaRusso NF, Eggen BJL, Jonker JW, Robbins PD, Niedernhofer LJ, Kruit JK. Failure to repair endogenous DNA damage in beta-cells causes adult-onset diabetes in mice. Aging Biol. 2023; 1 (1) Epub 2023 Oct 23
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Grant CW, Juran BD, Ali AH, Schlicht EM, Bianchi JK, Hu X, Liang Y, Jarrell Z, Liu KH, Go YM, Jones DP, Walker DI, Miller GW, Folseraas T, Karlsen TH, LaRusso NF, Gores GJ, Athreya AP, Lazaridis KN. Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis. Exposome. 2023; 3 (1):osac011 Epub 2023 Jan 05
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Singh Y, Jons WA, Eaton JE, Vesterhus M, Karlsen T, Bjoerk I, Abildgaard A, Jorgensen KK, Folseraas T, Little D, Gulamhusein AF, Petrovic K, Negard A, Conte GM, Sobek JD, Jagtap J, Venkatesh SK, Gores GJ, LaRusso NF, Lazaridis KN, Erickson BJ. Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. Eur Radiol Exp. 2022 Nov 18; 6 (1):58
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Olaizola P, Rodrigues PM, Caballero-Camino FJ, Izquierdo-Sanchez L, Aspichueta P, Bujanda L, Larusso NF, Drenth JPH, Larusso NF , Perugorria MJ, Banales JM. Genetics, pathobiology and therapeutic opportunities of polycystic liver disease. Nat Rev Gastroenterol Hepatol. 2022 Sep; 19 (9):585-604 Epub 2022 May 13
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Trussoni CE, O'Hara SP, LaRusso NF. Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target. Semin Immunopathol. 2022 Jul; 44 (4):527-544 Epub 2022 Feb 17
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Trussoni CE, O'Hara SP, LaRusso NF. Correction to: Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target. Semin Immunopathol. 2022 Jul; 44 (4):545-546
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Masyuk AI, Masyuk TV, Trussoni CE, Pirius NE, LaRusso NF. Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins. Hepatology. 2022 May; 75 (5):1110-1122 Epub 2022 Feb 08
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Walker DI, Juran BD, Cheung AC, Schlicht EM, Liang Y, Niedzwiecki M, LaRusso NF, Gores GJ, Jones DP, Miller GW, Lazaridis KN. High-Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases. Hepatol Commun. 2022 May; 6 (5):965-979 Epub 2021 Nov 26
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Navarro-Corcuera A, Sehrawat TS, Jalan-Sakrikar N, Gibbons HR, Pirius NE, Khanal S, Hamdan FH, Aseem SO, Cao S, Banales JM, Kang N, Faubion WA, LaRusso NF, Shah VH, Huebert RC. Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex. J Hepatol. 2022 Apr; 76 (4):921-933 Epub 2021 Dec 23
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Cheung AC, Juran BD, Schlicht EM, McCauley BM, Atkinson EJ, Moore R, Heimbach JK, Watt KD, Wu TT, LaRusso NF, Gores GJ, Sun Z, Lazaridis KN. DNA methylation profile of liver tissue in end-stage cholestatic liver disease. Epigenomics. 2022 Apr; 14 (8):481-497 Epub 2022 Apr 27
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Bogert PS, O'Hara SP, LaRusso NF. Cellular senescence in the cholangiopathies. Curr Opin Gastroenterol. 2022 Mar 1; 38 (2):121-127
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Jalan-Sakrikar N, De Assuncao TM, Navarro-Corcuera A, Hamdan FH, Loarca L, Kirkeby LA, Resch ZT, O'Hara SP, Juran BD, Lazaridis KN, Rosen CB, Heimbach JK, Taner T, Shah VH, LaRusso NF, Huebert RC. Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation. Hepatol Commun. 2022 Feb; 6 (2):345-360 Epub 2021 Aug 25
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Masyuk TV, Masyuk AI, LaRusso NF. Polycystic Liver Disease: Advances in Understanding and Treatment. Annu Rev Pathol. 2022 Jan 24; 17:251-269 Epub 2021 Nov 01
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Eaton JE, Welle CL, Monahan H, Tahboub Amawi AD, Idilman I, Harmsen WS, Dzyubak B, Beiermann EW, Bakhshi Z, Gores GJ, LaRusso NF, Gossard AA, Lazaridis KN, Venkatesh SK. Comparative Performance of Quantitative and Qualitative Magnetic Resonance Imaging Metrics in Primary Sclerosing Cholangitis. Gastro Hep Adv. 2022; 1 (3):287-295 Epub 2022 Mar 30
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Nishio T, Koyama Y, Liu X, Rosenthal SB, Yamamoto G, Fuji H, Baglieri J, Li N, Brenner LN, Iwaisako K, Taura K, Hagood JS, LaRusso NF, Bera TK, Pastan I, Brenner DA, Kisseleva T. Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Proc Natl Acad Sci U S A. 2021 Jul 20; 118 (29)
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Mousa OY, Juran BD, McCauley BM, Vesterhus MN, Folseraas T, Turgeon CT, Ali AH, Schlicht EM, Atkinson EJ, Hu C, Harnois D, Carey EJ, Gossard AA, Oglesbee D, Eaton JE, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN. Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation. Hepatology. 2021 Jul; 74 (1):281-295 Epub 2021 June 15
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Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. An aged immune system drives senescence and ageing of solid organs. Nature. 2021 Jun; 594 (7861):100-105 Epub 2021 May 12
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Alsuraih M, O'Hara SP, Woodrum JE, Pirius NE, LaRusso NF. Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 (-/-) mouse. JHEP Rep. 2021 Jun; 3 (3):100250 Epub 2021 Jan 27
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Eaton JE, Welle CL, Bakhshi Z, Sheedy SP, Idilman IS, Gores GJ, Rosen CB, Heimbach JK, Taner T, Harnois DM, Lindor KD, LaRusso NF, Gossard AA, Lazaridis KN, Venkatesh SK. Early Cholangiocarcinoma Detection With Magnetic Resonance Imaging Versus Ultrasound in Primary Sclerosing Cholangitis. Hepatology. 2021 May; 73 (5):1868-1881 Epub 2021 Apr 19
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Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Santos-Laso A, Azkargorta M, Elortza F, Martinez-Chantar ML, Perugorria MJ, Aspichueta P, Marzioni M, LaRusso NF, Bujanda L, Drenth JPH, Banales JM. Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models. J Hepatol. 2021 Feb; 74 (2):394-406 Epub 2020 Sept 17
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Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Alvarez EMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo WL, Araya J, Arden C, Arevalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Banreti A, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barila D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Bhattacharya R, Bi X, et al, Cao B, Chen Q, Chen W, Chen Z, Chung S, Colombo MI, Cui J, Deng Z, Dong Z, Duan X, Gao F, Gao M, Ge L, Guo C, Gupta SK, Hu D, Hu W, Inman DM, Jackson WT, Jia L, Jiang Y, Kang SS, Kukar T, Kumar D, LaRusso NF, Lee GM, Lee JY, Lee SJ, Lee WH, Lewis PA, Li J, Li Y, Lin X, Liu H, Liu J, Liu M, Luo Z, Ma C, Maeda A, Martin KR, Martinez J, Masyuk AI, Masyuk TV, McNiven MA, Mukhopadhyay S, Nguyen LT, Passos JF, Peng Y, Qiang L, Ryan KM, Sathyanarayan A, Schott MB, Schulze RJ, Sharma S, Shen H, Shi J, Shridhar V, Singh S, Stevens C, Sun G, Sun Q, Sun Y, Tang J, Thomas SM, Walker DW, Wang G, Wang Q, Wen X, Wilson RA, Xia H, Xiao H, Xiao J, Yang J, Yu H, Yuan J, Yuan S, Zhang B, Zhang L, Zhang M, Zhang P, Zhang S, Zhang W, Zhang X, Zhang Y, Zhang Z, Zhao H, Zhou B, Zhou Z. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021 Jan; 17 (1):1-382 Epub 2021 Feb 08
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Davies BA, Morton LO, Jefferson JR, Rozeveld CN, Doskey LC, LaRusso NF, Katzmann DJ. Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles. Mol Biol Cell. 2020 Oct 15; 31 (22):2463-2474 Epub 2020 Aug 26
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Al Suraih MS, Trussoni CE, Splinter PL, LaRusso NF, O'Hara SP. Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. Liver Int. 2020 Oct; 40 (10):2455-2468 Epub 2020 July 07
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Osman KT, Maselli DB, Idilman IS, Rowan DJ, Viehman JK, Harmsen WS, Harnois DM, Carey EJ, Gossard AA, LaRusso NF, Lindor KD, Venkatesh SK, Eaton JE. Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis. J Clin Gastroenterol. 2020 Sep 23 Epub 2020 Sept 23
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Hogan MC, Chamberlin JA, Vaughan LE, Waits AL, Banks C, Leistikow K, Oftsie T, Madsen C, Edwards M, Glockner J, Kremers WK, Harris PC, LaRusso NF, Torres VE, Masyuk TV. Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement: A Randomized Clinical Trial. Clin J Am Soc Nephrol. 2020 Sep 7; 15 (9):1267-1278 Epub 2020 Aug 25
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Santos-Laso A, Izquierdo-Sanchez L, Rodrigues PM, Huang BQ, Azkargorta M, Lapitz A, Munoz-Garrido P, Arbelaiz A, Caballero-Camino FJ, Fernandez-Barrena MG, Jimenez-Aguero R, Argemi J, Aragon T, Elortza F, Marzioni M, Drenth JPH, LaRusso NF, Bujanda L, Perugorria MJ, Banales JM. Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets. Liver Int. 2020 Jul; 40 (7):1670-1685 Epub 2020 May 06
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Kowdley KV, Vuppalanchi R, Levy C, Floreani A, Andreone P, LaRusso NF, Shrestha R, Trotter J, Goldberg D, Rushbrook S, Hirschfield GM, Schiano T, Jin Y, Pencek R, MacConell L, Shapiro D, Bowlus CL, AESOP Study Investigators. A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis. J Hepatol. 2020 Jul; 73 (1):94-101 Epub 2020 Mar 10
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Eaton JE, Sen A, Hoodeshenas S, Schleck CD, Harmsen WS, Gores GJ, LaRusso NF, Gossard AA, Lazaridis KN, Venkatesh SK. Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2020 Jun; 18 (7):1576-1583.e1 Epub 2019 Nov 01
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Calderon G, McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes. EBioMedicine. 2020 May; 55:102759 Epub 2020 Apr 25
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Bakhshi Z, Hilscher MB, Gores GJ, Harmsen WS, Viehman JK, LaRusso NF, Gossard AA, Lazaridis KN, Lindor KD, Eaton JE. An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort. J Gastroenterol. 2020 May; 55 (5):523-532 Epub 2020 Jan 13
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Guicciardi ME, Trussoni CE, LaRusso NF, Gores GJ. The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis. Hepatology. 2020 Feb; 71 (2):741-748
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Eaton JE, Vesterhus M, McCauley BM, Atkinson EJ, Schlicht EM, Juran BD, Gossard AA, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN. Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning. Hepatology. 2020 Jan; 71 (1):214-224 Epub 2018 Dec 28
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O'Hara SP, Splinter PL, Trussoni CE, Guicciardi ME, Splinter NP, Al Suraih MS, Nasser-Ghodsi N, Stollenwerk D, Gores GJ, LaRusso NF. The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. J Biol Chem. 2019 Dec 6; 294 (49):18698-18713 Epub 2019 Oct 28
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Martin WP, Vaughan LE, Yoshida K, Takahashi N, Edwards ME, Metzger A, Senum SR, Masyuk TV, LaRusso NF, Griffin MD, El-Zoghby Z, Harris PC, Kremers WK, Nagorney DM, Kamath PS, Torres VE, Hogan MC. Bacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Disease. Mayo Clin Proc Innov Qual Outcomes. 2019 Jun; 3 (2):149-159 Epub 2019 May 27
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Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nat Rev Gastroenterol Hepatol. 2019 May; 16 (5):269-281
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Eaton JE, Nelson KM, Gossard AA, Carey EJ, Tabibian JH, Lindor KD, LaRusso NF. Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study. Scand J Gastroenterol. 2019 May; 54 (5):633-639 Epub 2019 May 26
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Abramyan O, LaRusso NF, Tabibian JH. Pancreatobiliary Ductal Dilatation: Unique Pathobiological Processes and Endoscopic Revelations. Gastroenterology. 2019 Mar; 156 (4):876-878 Epub 2018 Oct 26
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Berry R, Han JY, Kardashian AA, LaRusso NF, Tabibian JH. Hemobilia: Etiology, diagnosis, and treatment(). Liver Res. 2018 Dec; 2 (4):200-208 Epub 2018 Sept 22
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Tietz-Bogert PS, Kim M, Cheung A, Tabibian JH, Heimbach JK, Rosen CB, Nandakumar M, Lazaridis KN, LaRusso NF, Sung J, O'Hara SP. Metabolomic Profiling of Portal Blood and Bile Reveals Metabolic Signatures of Primary Sclerosing Cholangitis. Int J Mol Sci. 2018 Oct 16; 19 (10)
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Guicciardi ME, Trussoni CE, Krishnan A, Bronk SF, Lorenzo Pisarello MJ, O'Hara SP, Splinter PL, Gao Y, Vig P, Revzin A, LaRusso NF, Gores GJ. Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice. J Hepatol. 2018 Sep; 69 (3):676-686 Epub 2018 May 24
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Mansini AP, Lorenzo Pisarello MJ, Thelen KM, Cruz-Reyes M, Peixoto E, Jin S, Howard BN, Trussoni CE, Gajdos GB, LaRusso NF, Perugorria MJ, Banales JM, Gradilone SA. MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma. Hepatology. 2018 Aug; 68(2):561-573. Epub 2018 May 21.
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Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 2018 Jul; 17:259-273 Epub 2018 Apr 13
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Mouchli MA, Kurtin PJ, LaRusso NF. A 59-Year-Old Man With New Jaundice. Gastroenterology. 2018 Jun; 154 (8):2035-2036 Epub 2017 Sept 09
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Masyuk TV, Masyuk AI, LaRusso NF. Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis. Hepatology 2018 Jun; 67 (6):2462-2464 Epub 2018 Apr 19
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Murillo Perez CF, Goet JC, Lammers WJ, Gulamhusein A, van Buuren HR, Ponsioen CY, Carbone M, Mason A, Corpechot C, Invernizzi P, Mayo MJ, Battezzati PM, Floreani A, Pares A, Nevens F, Kowdley KV, Bruns T, Dalekos GN, Thorburn D, Hirschfield G, LaRusso NF, Lindor KD, Zachou K, Poupon R, Trivedi PJ, Verhelst X, Janssen HLA, Hansen BE, GLOBAL PBC Study Group. Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history. Hepatology. 2018 May; 67 (5):1920-1930 Epub 2018 Apr 06
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Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Aguero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP, LaRusso NF, Bujanda L, Marin JJG, Banales JM. MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. Hepatology. 2018 Apr; 67 (4):1420-1440 Epub 2018 Feb 21
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Lorenzo Pisarello M, Masyuk TV, Gradilone SA, Masyuk AI, Ding JF, Lee PY, LaRusso NF. Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease. Am J Pathol. 2018 Apr; 188 (4):981-994 Epub 2018 Jan 31
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Cheung AC, Lorenzo Pisarello MJ, LaRusso NF. Pathobiology of biliary epithelia. Biochim Biophys Acta Mol Basis Dis. 2018 Apr; 1864 (4 Pt B):1220-1231 Epub 2017 July 15
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Masyuk AI, Masyuk TV, Lorenzo Pisarello MJ, Ding JF, Loarca L, Huang BQ, LaRusso NF. Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target. Hepatology. 2018 Mar; 67 (3):1088-1108 Epub 2018 Feb 01
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Moncsek A, Al-Suraih MS, Trussoni CE, O'Hara SP, Splinter PL, Zuber C, Patsenker E, Valli PV, Fingas CD, Weber A, Zhu Y, Tchkonia T, Kirkland JL, Gores GJ, Müllhaupt B, LaRusso NF, Mertens JC. Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice. Hepatology. 2018 Jan; 67(1):247-259. Epub 2017 Nov 29.
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Loarca L, De Assuncao TM, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello MJL, Gores GJ, Huebert RC, LaRusso NF. Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. Lab Invest. 2017 Nov; 97 (11):1385-1396 Epub 2017 Sept 11
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O'Hara SP, Karlsen TH, LaRusso NF. Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? Gut. 2017 Nov; 66 (11):1873-1877 Epub 2017 July 21
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Masyuk TV, Masyuk AI, Lorenzo Pisarello M, Howard BN, Huang BQ, Lee PY, Fung X, Sergienko E, Ardecky RJ, Chung TDY, Pinkerton AB, LaRusso NF. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Galphas signaling. Hepatology. 2017 Oct; 66 (4):1197-1218 Epub 2017 Aug 26
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Holditch SJ, Schreiber CA, Harris PC, LaRusso NF, Ramirez-Alvarado M, Cataliotti A, Torres VE, Ikeda Y. B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease. Kidney Int. 2017 Sep; 92 (3):657-668 Epub 2017 Apr 14
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Kittanamongkolchai W, El-Zoghby ZM, Eileen Hay J, Wiesner RH, Kamath PS, LaRusso NF, Watt KD, Cramer CH, Leung N. Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease. Hepatol Int. 2017 Jul; 11 (4):384-389 Epub 2016 Dec 08
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Cheung AC, Lazaridis KN, LaRusso NF, Gores GJ. Emerging pharmacologic therapies for primary sclerosing cholangitis. Curr Opin Gastroenterol. 2017 May; 33 (3):149-157
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Cheung AC, LaRusso NF, Gores GJ, Lazaridis KN. Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. Semin Liver Dis. 2017 May; 37 (2):159-174 Epub 2017 May 31
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O'Hara SP, Splinter PL, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF. ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem. 2017 Mar 24; 292 (12):4833-4846 Epub 2017 Feb 08
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LaRusso NF, Tabibian JH, O'Hara SP. Role of the Intestinal Microbiome in Cholestatic Liver Disease. Dig Dis. 2017; 35 (3):166-168 Epub 2017 Mar 01
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Masyuk TV, Masyuk AI, LaRusso NF. Therapeutic Targets in Polycystic Liver Disease. Curr Drug Targets. 2017; 18 (8):950-957
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Gradilone SA, Pisarello MJL, LaRusso NF. Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma. Curr Drug Targets. 2017; 18 (8):958-963
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Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H. Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology. 2016 Dec; 64 (6):2219-2233 Epub 2016 Oct 20
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Lazaridis KN, LaRusso NF. Primary Sclerosing Cholangitis. N Engl J Med. 2016 Sep 22; 375 (12):1161-70
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Eaton JE, Dzyubak B, Venkatesh SK, Smyrk TC, Gores GJ, Ehman RL, LaRusso NF, Gossard AA, Lazaridis KN. Performance of magnetic resonance elastography in primary sclerosing cholangitis. J Gastroenterol Hepatol. 2016 Jun; 31 (6):1184-90
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Tabibian JH, Varghese C, LaRusso NF, O'Hara SP. The enteric microbiome in hepatobiliary health and disease. Liver Int. 2016 Apr; 36 (4):480-7 Epub 2015 Dec 12
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Shah VH, Gores GJ, LaRusso NF. Hail to the chief-Keith Lindor, our new AASLD president. Hepatology. 2016 Feb; 63 (2):357-9 Epub 2015 Dec 18
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Lynn A, Tabibian JH, LaRusso NF. An Octogenarian With Acute Epigastric Pain: More Than Meets the Eye. Gastroenterology. 2016 Feb; 150: (2)e5-6.
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Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey LR, LaRusso NF. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology. 2016 Jan; 63 (1):185-96 Epub 2015 Aug 10
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Munoz-Garrido P, Marin JJ, Perugorria MJ, Urribarri AD, Erice O, Saez E, Uriz M, Sarvide S, Portu A, Concepcion AR, Romero MR, Monte MJ, Santos-Laso A, Hijona E, Jimenez-Aguero R, Marzioni M, Beuers U, Masyuk TV, LaRusso NF, Prieto J, Bujanda L, Drenth JP, Banales JM. Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease. J Hepatol. 2015 Oct; 63 (4):952-61 Epub 2015 June 01
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Pisarello MJ, Loarca L, Ivanics T, Morton L, LaRusso N. MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment. J Clin Med. 2015 Aug 26; 4 (9):1688-712
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Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14 (4):644-58 Epub 2015 Apr 22
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Hogan MC, Masyuk T, Bergstralh E, Li B, Kremers WK, Vaughan LE, Ihrke A, Severson AL, Irazabal MV, Glockner J, LaRusso NF, Torres VE. Efficacy of 4 Years of Octreotide Long-Acting Release Therapy in Patients With Severe Polycystic Liver Disease. Mayo Clin Proc. 2015 Aug; 90(8):1030-7. Epub 2015 Jul 09.
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Lazaridis KN, LaRusso NF. The Cholangiopathies. Mayo Clin Proc. 2015 Jun; 90 (6):791-800 Epub 2015 May 06
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Tabibian JH, Varghese C, O'Hara SP, LaRusso NF. Microbiome-Immune Interactions and Liver Disease. Clin Liver Dis (Hoboken). 2015 Apr; 5 (4):83-85 Epub 2015 May 07
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Gradilone SA, O'Hara SP, Masyuk TV, Pisarello MJ, LaRusso NF. MicroRNAs and benign biliary tract diseases. Semin Liver Dis. 2015 Feb; 35 (1):26-35 Epub 2015 Jan 29
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La Russo NF, Spurrier B, Farrugia G. Fusion innovation. T and D. 2015; 69(1).
Masyuk TV, Masyuk AI, LaRusso NF. TGR5 in the Cholangiociliopathies. Dig Dis. 2015; 33 (3):420-5 Epub 2015 May 27
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Perugorria MJ, Masyuk TV, Marin JJ, Marzioni M, Bujanda L, LaRusso NF, Banales JM. Polycystic liver diseases: advanced insights into the molecular mechanisms. Nat Rev Gastroenterol Hepatol. 2014 Dec; 11 (12):750-61 Epub 2014 Sept 30
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Masyuk AI, Gradilone SA, LaRusso NF. Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: are they independent or coordinated molecular events? Hepatology. 2014 Nov; 60 (5):1783-5 Epub 2014 Oct 02
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Urribarri AD, Munoz-Garrido P, Perugorria MJ, Erice O, Merino-Azpitarte M, Arbelaiz A, Lozano E, Hijona E, Jimenez-Aguero R, Fernandez-Barrena MG, Jimeno JP, Marzioni M, Marin JJ, Masyuk TV, LaRusso NF, Prieto J, Bujanda L, Banales JM. Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases. Gut. 2014 Oct; 63 (10):1658-67 Epub 2014 Jan 16
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Tabibian JH, Trussoni CE, O'Hara SP, Splinter PL, Heimbach JK, LaRusso NF. Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis. Lab Invest. 2014 Oct; 94 (10):1126-33 Epub 2014 July 21
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O'Hara SP, Gradilone SA, Masyuk TV, Tabibian JH, LaRusso NF. MicroRNAs in Cholangiopathies. Curr Pathobiol Rep. 2014 Sep 1; 2 (3):133-142
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Tabibian JH, O'Hara SP, Splinter PL, Trussoni CE, LaRusso NF. Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis. Hepatology. 2014 Jun; 59 (6):2263-75 Epub 2014 Apr 25
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Gradilone SA, Habringer S, Masyuk TV, Howard BN, Masyuk AI, Larusso NF. HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis. Am J Pathol. 2014 Mar; 184 (3):600-8 Epub 2014 Jan 13
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Masyuk TV, Lee SO, Radtke BN, Stroope AJ, Huang B, Banales JM, Masyuk AI, Splinter PL, Gradilone SA, Gajdos GB, LaRusso NF. Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. Am J Pathol. 2014 Jan; 184 (1):110-21 Epub 2013 Nov 07
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Shah PP, Bechara JP, Kolars J, Drefahl M, LaRusso N, Wood D, Spurrier B. Temporal elements in career selection decisions: An archival study investigating career decisions in medicine. Organization Science. 2014; 25(1):245-61.
Masyuk AI, Masyuk TV, Larusso NF. Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. J Hepatol. 2013 Sep; 59 (3):621-5 Epub 2013 Apr 02
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Masyuk TV, Radtke BN, Stroope AJ, Banales JM, Gradilone SA, Huang B, Masyuk AI, Hogan MC, Torres VE, Larusso NF. Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases. Hepatology. 2013 Jul; 58 (1):409-21 Epub 2013 Mar 06
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Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK, Brenner DA, Rustgi AK, Omary MB. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Gastroenterology. 2013 Jul; 145 (1):16-31
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Moreno-Luna LE, Yang JD, Sanchez W, Paz-Fumagalli R, Harnois DM, Mettler TA, Gansen DN, de Groen PC, Lazaridis KN, Narayanan Menon KV, Larusso NF, Alberts SR, Gores GJ, Fleming CJ, Slettedahl SW, Harmsen WS, Therneau TM, Wiseman GA, Andrews JC, Roberts LR. Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2013 Jun; 36 (3):714-23 Epub 2012 Oct 24
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Tietz Bogert PS, Huang BQ, Gradilone SA, Masyuk TV, Moulder GL, Ekker SC, Larusso NF. The zebrafish as a model to study polycystic liver disease. Zebrafish. 2013 Jun; 10 (2):211-7 Epub 2013 May 13
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Tabibian JH, Macura SI, O'Hara SP, Fidler JL, Glockner JF, Takahashi N, Lowe VJ, Kemp BJ, Mishra PK, Tietz PS, Splinter PL, Trussoni CE, LaRusso NF. Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography. Lab Invest. 2013 Jun; 93 (6):733-43 Epub 2013 Apr 15
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Masyuk AI, Huang BQ, Radtke BN, Gajdos GB, Splinter PL, Masyuk TV, Gradilone SA, LaRusso NF. Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1; 304 (11):G1013-24 Epub 2013 Apr 11
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Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB, LaRusso NF. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1; 73 (7):2259-70 Epub 2013 Jan 31
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O'Hara SP, Tabibian JH, Splinter PL, LaRusso NF. The dynamic biliary epithelia: molecules, pathways, and disease. J Hepatol. 2013 Mar; 58 (3):575-82 Epub 2012 Oct 17
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Hu G, Gong AY, Roth AL, Huang BQ, Ward HD, Zhu G, Larusso NF, Hanson ND, Chen XM. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathog. 2013; 9(4):e1003261. Epub 2013 Apr 04.
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Tabibian JH, Masyuk AI, Masyuk TV, O'Hara SP, LaRusso NF. Physiology of cholangiocytes. Compr Physiol. 2013 Jan; 3 (1):541-65
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Pruthi S, Stange KJ, Malagrino GD Jr, Chawla KS, LaRusso NF, Kaur JS. Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer. Mayo Clin Proc. 2013 Jan; 88(1):68-73.
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Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R. Role for Kruppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013; 8 (9):e75311 Epub 2013 Sept 17
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Wang X, Ye H, Ward CJ, Chu JY, Masyuk TV, Larusso NF, Harris PC, Chow BK, Torres VE. Insignificant effect of secretin in rodent models of polycystic kidney and liver disease. Am J Physiol Renal Physiol. 2012 Oct; 303 (7):F1089-98 Epub 2012 July 18
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Hogan MC, Masyuk TV, Page L, Holmes DR 3rd, Li X, Bergstralh EJ, Irazabal MV, Kim B, King BF, Glockner JF, Larusso NF, Torres VE. Somatostatin analog therapy for severe polycystic liver disease: results after 2 years. Nephrol Dial Transplant. 2012 Sep; 27 (9):3532-9 Epub 2012 July 06
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Banales JM, Saez E, Uriz M, Sarvide S, Urribarri AD, Splinter P, Tietz Bogert PS, Bujanda L, Prieto J, Medina JF, LaRusso NF. Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology. 2012 Aug; 56(2):687-97. Epub 2012 Jul 10.
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Asrani SK, LaRusso NF. Fibrolamellar hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus, and pulmonary emboli. Hepatology. 2012 Mar; 55(3):977-8.
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Masyuk TV, Radtke BN, Stroope AJ, Banales JM, Masyuk AI, Gradilone SA, Gajdos GB, Chandok N, Bakeberg JL, Ward CJ, Ritman EL, Kiyokawa H, LaRusso NF. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Gastroenterology. 2012 Mar; 142 (3):622-633.e4 Epub 2011 Dec 07
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O'Hara SP, Bogert PS, Trussoni CE, Chen X, LaRusso NF. TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis. J Parasitol. 2011 Oct; 97 (5):813-21 Epub 2011 Mar 23
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Severson MA, Wood DL, Chastain CN, Lee LG, Rees AC, Agerter DC, Holtz CP, Broers JK, Savoleinen KH, Spurrier BR, Larusso NF. Health reform: a community experience using design research as a guide. Mayo Clin Proc. 2011 Oct; 86 (10):973-80
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Huebert RC, Jagavelu K, Hendrickson HI, Vasdev MM, Arab JP, Splinter PL, Trussoni CE, Larusso NF, Shah VH. Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs. Am J Pathol. 2011 Oct; 179 (4):1851-60 Epub 2011 Aug 18
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O'Hara SP, Splinter PL, Trussoni CE, Gajdos GB, Lineswala PN, LaRusso NF. Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation. J Biol Chem. 2011 Sep 2; 286 (35):30352-30360 Epub 2011 July 13
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Guntaka SR, Samak G, Seth A, LaRusso NF, Rao R. Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium. Lab Invest. 2011 Sep; 91(9):1396-409. Epub 2011 May 23.
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Larusso NF, Masyuk TV. The role of cilia in the regulation of bile flow. Dig Dis. 2011; 29 (1):6-12 Epub 2011 June 17
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Ninlawan K, O'Hara SP, Splinter PL, Yongvanit P, Kaewkes S, Surapaitoon A, LaRusso NF, Sripa B. Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. Parasitol Int. 2010 Dec; 59(4):616-21. Epub 2010 Sep 29.
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Huebert RC, Jagavelu K, Liebl AF, Huang BQ, Splinter PL, LaRusso NF, Urrutia RA, Shah VH. Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis. Lab Invest. 2010 Dec; 90 (12):1770-81 Epub 2010 July 19
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Masyuk AI, Huang BQ, Ward CJ, Gradilone SA, Banales JM, Masyuk TV, Radtke B, Splinter PL, LaRusso NF. Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299 (4):G990-9 Epub 2010 July 15
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Gradilone SA, Masyuk TV, Huang BQ, Banales JM, Lehmann GL, Radtke BN, Stroope A, Masyuk AI, Splinter PL, LaRusso NF. Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD. Gastroenterology. 2010 Jul; 139 (1):304-14.e2 Epub 2010 Apr 14
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O'Hara SP, Gajdos GB, Trussoni CE, Splinter PL, LaRusso NF. Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization. Infect Immun. 2010 Jul; 78 (7):2927-36 Epub 2010 May 10
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Huebert RC, Vasdev MM, Shergill U, Das A, Huang BQ, Charlton MR, LaRusso NF, Shah VH. Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis. Hepatology. 2010 Jul; 52 (1):238-48
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Hogan MC, Masyuk TV, Page LJ, Kubly VJ, Bergstralh EJ, Li X, Kim B, King BF, Glockner J, Holmes DR 3rd, Rossetti S, Harris PC, LaRusso NF, Torres VE. Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease. J Am Soc Nephrol. 2010 Jun; 21 (6):1052-61 Epub 2010 Apr 29
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Stroope A, Radtke B, Huang B, Masyuk T, Torres V, Ritman E, LaRusso N. Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease. Am J Pathol. 2010 Mar; 176 (3):1282-91 Epub 2010 Jan 21
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O'Hara SP, Splinter PL, Gajdos GB, Trussoni CE, Fernandez-Zapico ME, Chen XM, LaRusso NF. NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem. 2010 Jan 1; 285 (1):216-25 Epub 2009 Nov 10
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Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ. MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology. 2009 May; 49(5):1595-601.
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Masyuk T, Masyuk A, LaRusso N. Cholangiociliopathies: genetics, molecular mechanisms and potential therapies. Curr Opin Gastroenterol. 2009 May; 25 (3):265-71
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Masyuk T, Masyuk A, LaRusso N. MicroRNAs in cholangiociliopathies. Cell Cycle. 2009 May 1; 8 (9):1324-8 Epub 2009 May 23
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O'Hara SP, Small AJ, Gajdos GB, Badley AD, Chen XM, Larusso NF. HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum. J Infect Dis. 2009 Apr 15; 199 (8):1195-204
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Hogan MC, Manganelli L, Woollard JR, Masyuk AI, Masyuk TV, Tammachote R, Huang BQ, Leontovich AA, Beito TG, Madden BJ, Charlesworth MC, Torres VE, LaRusso NF, Harris PC, Ward CJ. Characterization of PKD protein-positive exosome-like vesicles. J Am Soc Nephrol. 2009 Feb; 20 (2):278-88 Epub 2009 Jan 21
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Brennan MD, Duncan AK, Armbruster RR, Montori VM, Feyereisn WL, LaRusso NF. The application of design principles to innovate clinical care delivery. J Healthc Qual. 2009 Jan-Feb; 31 (1):5-9
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Huang B, Masyuk T, LaRusso N. Isolation of primary cilia for morphological analysis. Methods Cell Biol. 2009; 94:103-15. Epub 2009 Dec 23.
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Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF, LaRusso NF. The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD). Hepatology. 2009 Jan; 49 (1):160-74
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O'Hara SP, Mott JL, Splinter PL, Gores GJ, LaRusso NF. MicroRNAs: key modulators of posttranscriptional gene expression. Gastroenterology. 2009 Jan; 136 (1):17-25 Epub 2008 Dec 03
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Sirica AE, Nathanson MH, Gores GJ, Larusso NF. Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference. Hepatology. 2008 Dec; 48(6):2040-6.
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Shanafelt TD, West CP, Poland GA, LaRusso NF, Menaker R, Bahn RS. Principles to promote physician satisfaction and work-life balance. Minn Med. 2008 Dec; 91(12):41-3.
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Dyrbye LN, Lindor KD, LaRusso NF, Cook DA. Research productivity of graduates from 3 physician-scientist training programs. Am J Med. 2008 Dec; 121(12):1107-13.
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Banales JM, Masyuk TV, Bogert PS, Huang BQ, Gradilone SA, Lee SO, Stroope AJ, Masyuk AI, Medina JF, LaRusso NF. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am J Pathol. 2008 Dec; 173 (6):1637-46 Epub 2008 Nov 06
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Wood DL, Brennan MD, Chaudhry R, Chihak AA, Feyereisn WL, Woychick NL, Hagen PT, Curtright JW, Naessens JM, Spurrier BR, Larusso NF. Standardized care processes to improve quality and safety of patient care in a large academic practice: the Plummer Project of the Department of Medicine, Mayo Clinic. Health Serv Manage Res. 2008 Nov; 21 (4):276-80
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Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest. 2008 Nov; 118 (11):3714-24 Epub 2008 Oct 23
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Liu JJ, Glickman JN, Masyuk AI, Larusso NF. Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains. J Gastroenterol Hepatol. 2008 Oct; 23(10):1596-602. Epub 2008 Aug 20.
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Masyuk AI, Gradilone SA, Banales JM, Huang BQ, Masyuk TV, Lee SO, Splinter PL, Stroope AJ, Larusso NF. Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295 (4):G725-34 Epub 2008 Aug 07
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Chen XM, O'Hara SP, LaRusso NF. The immunobiology of cholangiocytes. Immunol Cell Biol. 2008 Aug-Sep; 86(6):497-505. Epub 2008 May 27.
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Masyuk AI, Masyuk TV, LaRusso NF. Cholangiocyte primary cilia in liver health and disease. Dev Dyn. 2008 Aug; 237 (8):2007-12
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O'Hara SP, Small AJ, Chen XM, LaRusso NF. Host cell actin remodeling in response to Cryptosporidium. Subcell Biochem. 2008; 47:92-100
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Gradilone SA, Masyuk AI, Splinter PL, Banales JM, Huang BQ, Tietz PS, Masyuk TV, Larusso NF. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A. 2007 Nov 27; 104 (48):19138-43 Epub 2007 Nov 16
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Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, Lesage G, Akiba Y, Kaunitz JD, Ehrlich BE, Larusso NF, Nathanson MH. Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology. 2007 Nov; 133(5):1592-602. Epub 2007 Aug 14.
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Chen XM, Splinter PL, O'Hara SP, LaRusso NF. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem. 2007 Sep 28; 282 (39):28929-28938 Epub 2007 July 27
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Woollard JR, Punyashtiti R, Richardson S, Masyuk TV, Whelan S, Huang BQ, Lager DJ, vanDeursen J, Torres VE, Gattone VH, LaRusso NF, Harris PC, Ward CJ. A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. Kidney Int. 2007 Aug; 72(3):328-36. Epub 2007 May 23.
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Segovis CM, Mueller PS, Rethlefsen ML, LaRusso NF, Litin SC, Tefferi A, Habermann TM. If you feed them, they will come: a prospective study of the effects of complimentary food on attendance and physician attitudes at medical grand rounds at an academic medical center. BMC Med Educ. 2007 Jul 12; 7:22 Epub 2007 July 12
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Sheth P, Delos Santos N, Seth A, LaRusso NF, Rao RK. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G308-18. Epub 2007 Apr 19.
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Bogert PT, LaRusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2007 May; 23(3):299-305.
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Leerapun A, Suravarapu SV, Bida JP, Clark RJ, Sanders EL, Mettler TA, Stadheim LM, Aderca I, Moser CD, Nagorney DM, LaRusso NF, de Groen PC, Menon KV, Lazaridis KN, Gores GJ, Charlton MR, Roberts RO, Therneau TM, Katzmann JA, Roberts LR. The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population. Clin Gastroenterol Hepatol. 2007 Mar; 5 (3):394-402; quiz 267
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Masyuk TV, Masyuk AI, Torres VE, Harris PC, Larusso NF. Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. Gastroenterology. 2007 Mar; 132 (3):1104-16 Epub 2006 Dec 20
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O'Hara SP, Small AJ, Nelson JB, Badley AD, Chen XM, Gores GJ, Larusso NF. The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism. Infect Immun. 2007 Feb; 75 (2):684-96 Epub 2006 Nov 21
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Allina J, Hu B, Sullivan DM, Fiel MI, Thung SN, Bronk SF, Huebert RC, van de Water J, LaRusso NF, Gershwin ME, Gores GJ, Odin JA. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun. 2006 Dec; 27(4):232-41. Epub 2007 Jan 10.
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Nelson JB, O'Hara SP, Small AJ, Tietz PS, Choudhury AK, Pagano RE, Chen XM, LaRusso NF. Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains. Cell Microbiol. 2006 Dec; 8 (12):1932-45 Epub 2006 July 18
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Blechacz B, Splinter PL, Greiner S, Myers R, Peng KW, Federspiel MJ, Russell SJ, LaRusso NF. Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. Hepatology. 2006 Dec; 44 (6):1465-77
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Splinter PL, Lazaridis KN, Dawson PA, LaRusso NF. Cloning and expression of SLC10A4, a putative organic anion transport protein. World J Gastroenterol. 2006 Nov 14; 12 (42):6797-805
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Hiesberger T, Gourley E, Erickson A, Koulen P, Ward CJ, Masyuk TV, Larusso NF, Harris PC, Igarashi P. Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C. J Biol Chem. 2006 Nov 10; 281(45):34357-64. Epub 2006 Sep 06.
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Masyuk AI, Masyuk TV, Splinter PL, Huang BQ, Stroope AJ, LaRusso NF. Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology. 2006 Sep; 131 (3):911-20
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Huang BQ, Masyuk TV, Muff MA, Tietz PS, Masyuk AI, Larusso NF. Isolation and characterization of cholangiocyte primary cilia. Am J Physiol Gastrointest Liver Physiol. 2006 Sep; 291(3):G500-9.
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Muff MA, Masyuk TV, Stroope AJ, Huang BQ, Splinter PL, Lee SO, Larusso NF. Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease. Lab Invest. 2006 Sep; 86 (9):940-50 Epub 2006 June 19
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LaRusso NF, Shneider BL, Black D, Gores GJ, James SP, Doo E, Hoofnagle JH. Primary sclerosing cholangitis: summary of a workshop. Hepatology. 2006 Sep; 44 (3):746-64
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Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA. Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. J Pediatr. 2006 Aug; 149(2):159-64.
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Tietz PS, Larusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2006 May; 22 (3):279-87
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Mazzone A, Tietz P, Jefferson J, Pagano R, LaRusso NF. Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes. Hepatology. 2006 Feb; 43(2):287-96.
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Masyuk AI, LaRusso NF. Aquaporins in the hepatobiliary system. Hepatology. 2006 Feb; 43 (2 Suppl 1):S75-81
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Tietz PS, McNiven MA, Splinter PL, Huang BQ, Larusso NF. Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes. Biol Cell. 2006 Jan; 98 (1):43-52
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Chen XM, O'Hara SP, Nelson JB, Splinter PL, Small AJ, Tietz PS, Limper AH, LaRusso NF. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol. 2005 Dec 1; 175 (11):7447-56
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O'Hara SP, Huang BQ, Chen XM, Nelson J, LaRusso NF. Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells. J Parasitol. 2005 Oct; 91(5):995-9.
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Laforenza U, Cova E, Gastaldi G, Tritto S, Grazioli M, LaRusso NF, Splinter PL, D'Adamo P, Tosco M, Ventura U. Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. J Nutr. 2005 Oct; 135(10):2329-36.
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Levy C, Lymp J, Angulo P, Gores GJ, Larusso N, Lindor KD. The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis. Dig Dis Sci. 2005 Sep; 50(9):1734-40.
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Keating RJ, LaRusso NF, Kolars JC. Perceived impact of duty hours limits on the fragmentation of patient care: results from an academic health center. Am J Med. 2005 Jul; 118(7):788-93.
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Tietz P, Jefferson J, Pagano R, Larusso NF. Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion. J Lipid Res. 2005 Jul; 46 (7):1426-32 Epub 2005 Apr 16
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Chen XM, O'Hara SP, Huang BQ, Splinter PL, Nelson JB, LaRusso NF. Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion. Proc Natl Acad Sci U S A. 2005 May 3; 102 (18):6338-43 Epub 2005 Apr 25
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Tietz PS, LaRusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2005 May; 21 (3):337-43
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Marinelli RA, Tietz PS, LaRusso NF. Regulated vesicle trafficking of membrane transporters in hepatic epithelia. J Hepatol. 2005 Apr; 42(4):592-603.
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Gradilone SA, Tietz PS, Splinter PL, Marinelli RA, LaRusso NF. Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B. BMC Physiol. 2005; 5:13. Epub 2005 Aug 18.
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Chen XM, O'Hara SP, Huang BQ, Nelson JB, Lin JJ, Zhu G, Ward HD, LaRusso NF. Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion. Infect Immun. 2004 Dec; 72 (12):6806-16
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Lazaridis KN, Strazzabosco M, Larusso NF. The cholangiopathies: disorders of biliary epithelia. Gastroenterology. 2004 Nov; 127 (5):1565-77
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Masyuk TV, Huang BQ, Masyuk AI, Ritman EL, Torres VE, Wang X, Harris PC, Larusso NF. Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. Am J Pathol. 2004 Nov; 165 (5):1719-30
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Chen XM, Splinter PL, Tietz PS, Huang BQ, Billadeau DD, LaRusso NF. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. J Biol Chem. 2004 Jul 23; 279 (30):31671-8 Epub 2004 May 07
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Kip NS, Lazaridis KN, Masyuk AI, Splinter PL, Huebert RC, LaRusso NF. Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion. World J Gastroenterol. 2004 May 15; 10 (10):1440-6
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Tietz PS, LaRusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2004 May; 20 (3):270-4
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Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Infect Immun. 2004 May; 72 (5):3011-21
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Huang BQ, Chen XM, LaRusso NF. Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: a morphologic study. J Parasitol. 2004 Apr; 90(2):212-21.
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Splinter PL, Masyuk AI, Marinelli RA, LaRusso NF. AQP4 transfected into mouse cholangiocytes promotes water transport in biliary epithelia. Hepatology. 2004 Jan; 39(1):109-16.
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Masyuk TV, Huang BQ, Ward CJ, Masyuk AI, Yuan D, Splinter PL, Punyashthiti R, Ritman EL, Torres VE, Harris PC, LaRusso NF. Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. Gastroenterology. 2003 Nov; 125 (5):1303-10
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Marinelli RA, Tietz PS, Caride AJ, Huang BQ, LaRusso NF. Water transporting properties of hepatocyte basolateral and canalicular plasma membrane domains. J Biol Chem. 2003 Oct 31; 278(44):43157-62.
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Ward CJ, Yuan D, Masyuk TV, Wang X, Punyashthiti R, Whelan S, Bacallao R, Torra R, LaRusso NF, Torres VE, Harris PC. Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet. 2003 Oct 15; 12(20):2703-10. Epub 2003 Aug 12.
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Ros JE, Roskams TAD, Geuken M, Havinga R, Splinter PL, Petersen BE, LaRusso NF, van der Kolk DM, Kuipers F, Faber KN, Muller M, Jansen PLM. ATP binding cassette transporter gene expression in rat liver progenitor cells. Gut. 2003 Jul; 52(7):1060-7.
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Chen XM, Huang BQ, Splinter PL, Cao H, Zhu G, McNiven MA, LaRusso NF. Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Gastroenterology. 2003 Jul; 125 (1):216-28
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Gradilone SA, Garcia F, Huebert RC, Tietz PS, Larocca MC, Kierbel A, Carreras FI, Larusso NF, Marinelli RA. Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. Hepatology. 2003 Jun; 37(6):1435-41.
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Tietz PS, Marinelli RA, Chen XM, Huang B, Cohn J, Kole J, McNiven MA, Alper S, LaRusso NF. Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. J Biol Chem. 2003 May 30; 278 (22):20413-9 Epub 2003 Mar 26
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Gong AY, Tietz PS, Muff MA, Splinter PL, Huebert RC, Strowski MZ, Chen XM, LaRusso NF. Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. Am J Physiol Cell Physiol. 2003 May; 284 (5):C1205-14
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Tietz P, LaRusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2003 May; 19 (3):264-9
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Mueller PS, Litin SC, Sowden ML, Habermann TM, LaRusso NF. Strategies for improving attendance at medical grand rounds at an academic medical center. Mayo Clin Proc. 2003 May; 78(5):549-53.
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Carreras FI, Gradilone SA, Mazzone A, Garcia F, Huang BQ, Ochoa JE, Tietz PS, Larusso NF, Calamita G, Marinelli RA. Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. Hepatology. 2003 May; 37(5):1026-33.
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Masyuk TV, Ritman EL, LaRusso NF. Hepatic artery and portal vein remodeling in rat liver: vascular response to selective cholangiocyte proliferation. Am J Pathol. 2003 Apr; 162 (4):1175-82
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Spirli C, Fabris L, Duner E, Fiorotto R, Ballardini G, Roskams T, Larusso NF, Sonzogni A, Okolicsanyi L, Strazzabosco M. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology. 2003 Mar; 124(3):737-53.
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Splinter PL, Masyuk AI, LaRusso NF. Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs. J Biol Chem. 2003 Feb 21; 278 (8):6268-74 Epub 2002 Dec 04
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Brandt TL, Romme CR, LaRusso NF, Lindor KD. A novel incentive system for faculty in an academic medical center. Ann Intern Med. 2002 Nov 5; 137 (9):738-43
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Masyuk AI, Masyuk TV, Tietz PS, Splinter PL, LaRusso NF. Intrahepatic bile ducts transport water in response to absorbed glucose. Am J Physiol Cell Physiol. 2002 Sep; 283 (3):C785-91
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Elkin PL, Sorensen B, De Palo D, Poland G, Poland G, Bailey KR, Wood DL, LaRusso NF. Optimization of a research web environment for academic internal medicine faculty. J Am Med Inform Assoc. 2002 Sep-Oct; 9 (5):472-8
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Hirata K, Dufour JF, Shibao K, Knickelbein R, O'Neill AF, Bode HP, Cassio D, St-Pierre MV, LaRusso NF, Leite MF, Nathanson MH. Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology. 2002 Aug; 36(2):284-96.
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Chen XM, LaRusso NF. Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy. Semin Liver Dis. 2002 Aug; 22(3):277-89.
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Gong AY, Masyuk AI, Splinter PL, Huebert RC, Tietz PS, LaRusso NF. Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units. Am J Physiol Cell Physiol. 2002 Jul; 283 (1):C338-46
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Huebert RC, Splinter PL, Garcia F, Marinelli RA, LaRusso NF. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. J Biol Chem. 2002 Jun 21; 277 (25):22710-7 Epub 2002 Apr 03
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Chen XM, Keithly JS, Paya CV, LaRusso NF. Cryptosporidiosis. N Engl J Med. 2002 May 30; 346(22):1723-31.
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Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ. In primary sclerosing cholangitis, gallbladder polyps are frequently malignant. Am J Gastroenterol. 2002 May; 97(5):1138-42.
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Alpini G, McGill JM, LaRusso NF. The pathobiology of biliary epithelia. Hepatology. 2002 May; 35(5):1256-68.
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Tietz P, LaRusso NF. Cholangiocyte biology. Curr Opin Gastroenterol. 2002 May; 18(3):360-5.
McDonald FS, Schultz HJ, LaRusso NF. A learner-centered academic career development curriculum. Acad Med. 2002 May; 77 (5):463
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Masyuk AI, Marinelli RA, LaRusso NF. Water transport by epithelia of the digestive tract. Gastroenterology. 2002 Feb; 122 (2):545-62
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Tietz PS, Chen XM, Gong AY, Huebert RC, Masyuk A, Masyuk T, Splinter PL, Masyuk T, LaRusso NF. Experimental models to study cholangiocyte biology. World J Gastroenterol. 2002 Feb; 8 (1):1-4
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Dranoff JA, Masyuk AI, Kruglov EA, LaRusso NF, Nathanson MH. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Am J Physiol Gastrointest Liver Physiol. 2001 Oct; 281(4):G1059-67.
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Jaiswal M, LaRusso NF, Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am J Physiol Gastrointest Liver Physiol. 2001 Sep; 281 (3):G626-34
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Cova E, Gong A, Marinelli RA, LaRusso NF. Water movement across rat bile duct units is transcellular and channel-mediated. Hepatology. 2001 Sep; 34(3):456-63.
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Jaiswal M, LaRusso NF, Nishioka N, Nakabeppu Y, Gores GJ. Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. Cancer Res. 2001 Sep 1; 61(17):6388-93.
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Nathanson MH, Burgstahler AD, Masyuk A, Larusso NF. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochem J. 2001 Aug 15; 358(Pt 1):1-5.
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Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A. Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest. 2001 Jul; 108(2):223-32.
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Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. Gastroenterology. 2001 Jun; 120 (7):1774-83
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Masyuk TV, Ritman EL, LaRusso NF. Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. Am J Pathol. 2001 Jun; 158 (6):2079-88
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Harnois DM, Angulo P, Jorgensen RA, Larusso NF, Lindor KD. High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis. Am J Gastroenterol. 2001 May; 96(5):1558-62.
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Garcia F, Kierbel A, Larocca MC, Gradilone SA, Splinter P, LaRusso NF, Marinelli RA. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. J Biol Chem. 2001 Apr 13; 276(15):12147-52. Epub 2001 Jan 17.
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Tietz PS, Hadac EM, Miller LJ, LaRusso NF. Upregulation of secretin receptors on cholangiocytes after bile duct ligation. Regul Pept. 2001 Feb 2; 97 (1):1-6
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Jaiswal M, LaRusso NF, Shapiro RA, Billiar TR, Gores GJ. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology. 2001 Jan; 120 (1):190-9
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Masyuk AI, Gong AY, Kip S, Burke MJ, LaRusso NF. Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions. Gastroenterology. 2000 Dec; 119 (6):1672-80
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Angulo P, Pearce DH, Angulo P, Johnson CD, Henry JJ, LaRusso NF, Petersen BT, Lindor KD. Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis. J Hepatol. 2000 Oct; 33 (4):520-7
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Lazaridis KN, Tietz P, Wu T, Kip S, Dawson PA, LaRusso NF. Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. Proc Natl Acad Sci U S A. 2000 Sep 26; 97 (20):11092-7
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Prall RT, Larusso NF, Larusso NF. Biliary tract physiology. Curr Opin Gastroenterol. 2000 Sep; 16 (5):432-6
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Bharucha AE, Jorgensen R, Lichtman SN, LaRusso NF, Lindor KD. A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. Am J Gastroenterol. 2000 Sep; 95 (9):2338-42
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Larkin JM, Woo B, Balan V, Marks DL, Oswald BJ, LaRusso NF, McNiven MA. Rab3D, a small GTP-binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes. Hepatology. 2000 Aug; 32(2):348-56.
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Kim WR, Therneau TM, Wiesner RH, Poterucha JJ, Benson JT, Malinchoc M, LaRusso NF, Lindor KD, Dickson ER. A revised natural history model for primary sclerosing cholangitis. Mayo Clin Proc. 2000 Jul; 75 (7):688-94
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Marinelli RA, Pham LD, Tietz PS, LaRusso NF. Expression of aquaporin-4 water channels in rat cholangiocytes. Hepatology. 2000 Jun; 31(6):1313-7.
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Prall RT, Lindor KD, Wiesner RH, LaRusso NF. Current therapies and clinical controversies in the management of primary sclerosing cholangitis. Curr Gastroenterol Rep. 2000 Apr; 2 (2):99-103
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Chen XM, LaRusso NF. Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells. Gastroenterology. 2000 Feb; 118 (2):368-79
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Roberts LR, LaRusso NF. Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks. World J Gastroenterol. 2000 Feb; 6(1):37-41.
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Patel AH, Harnois DM, Klee GG, LaRusso NF, Gores GJ. The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis. Am J Gastroenterol. 2000 Jan; 95 (1):204-7
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Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res. 2000 Jan 1; 60 (1):184-90
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Jaiswal M., LaRusso NF, Gores GJ. Cholangiocarcinoma, pro-inflammatory cyokines. Cancer Research Alert. 2000; 1:141-3.
Que FG, Phan VA, Phan VH, Celli A, Batts K, LaRusso NF, Gores GJ. Cholangiocarcinomas express Fas ligand and disable the Fas receptor. Hepatology. 1999 Dec; 30 (6):1398-404
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Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA. Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis. Hepatology. 1999 Nov; 30 (5):1121-7
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Angulo P, Larson DR, Therneau TM, LaRusso NF, Batts KP, Lindor KD. Time course of histological progression in primary sclerosing cholangitis. Am J Gastroenterol. 1999 Nov; 94(11):3310-3.
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de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM. Biliary tract cancers. N Engl J Med. 1999 Oct 28; 341 (18):1368-78
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Prall RT, Larusso NF, Larusso NF. Biliary tract physiology. Curr Opin Gastroenterol. 1999 Sep; 15 (5):423-9
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Chen XM, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. Am J Physiol. 1999 Sep; 277 (3):G599-608
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Kim WR, Poterucha JJ, Wiesner RH, LaRusso NF, Lindor KD, Petz J, Therneau TM, Malinchoc M, Dickson ER. The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis. Hepatology. 1999 Jun; 29 (6):1643-8
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Que FG, Phan VA, Phan VH, LaRusso NF, Gores GJ. GUDC inhibits cytochrome c release from human cholangiocyte mitochondria. J Surg Res. 1999 May 15; 83 (2):100-5
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Graziadei IW, Wiesner RH, Batts KP, Marotta PJ, LaRusso NF, Porayko MK, Hay JE, Gores GJ, Charlton MR, Ludwig J, Poterucha JJ, Steers JL, Krom RA. Recurrence of primary sclerosing cholangitis following liver transplantation. Hepatology. 1999 Apr; 29 (4):1050-6
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Angulo P, Bharucha AE, Jorgensen RA, DeSotel CK, Sandborn WJ, Larusso NF, Lindor KD. Oral nicotine in treatment of primary sclerosing cholangitis: a pilot study. Dig Dis Sci. 1999 Mar; 44 (3):602-7
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Larusso NF. The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice. P R Health Sci J. 1999 Mar; 18 (1):11-7
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Marinelli RA, Tietz PS, Pham LD, Rueckert L, Agre P, LaRusso NF. Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. Am J Physiol. 1999 Jan; 276 (1):G280-6
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Spirli C, Granato A, Zsembery A, Anglani F, Okolicsanyi L, LaRusso NF, Crepaldi G, Strazzabosco M. Functional polarity of Na/H+ and Cl-/HCO3- in a rat cholangiocyte cell line. Am J Physiol Gastrointest Liver Physiol. 1998 Dec; 38(6):G1236-G1245.
Tietz P, de Groen PC, Anderson NL, Sims C, Esquer-Blasco R, Meheus L, Raymackers J, Dauwe M, LaRusso NF. Cholangiocyte-specific rat liver proteins identified by establishment of a two-dimensional gel protein database. Electrophoresis. 1998 Dec; 19(18):3207-12.
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Spirli C, Granato A, Zsembery A, Anglani F, Okolicsanyi L, LaRusso NF, Crepaldi G, Strazzabosco M. Functional polarity of Na(+)/H(+)and Cl(-)/[Formula: see text]exchangers in a rat cholangiocyte cell line. Am J Physiol Gastrointest Liver Physiol. 1998 Dec 1; 275 (6):G1236-G1245
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Chen XM, Levine SA, Tietz P, Krueger E, McNiven MA, Jefferson DM, Mahle M, LaRusso NF. Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism. Hepatology. 1998 Oct; 28(4):906-13.
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Zsembery A, Spirli C, Granato A, LaRusso NF, Okolicsanyi L, Crepaldi G, Strazzabosco M. Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines. Hepatology. 1998 Oct; 28(4):914-20.
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Celli A, Que FG, Gores GJ, LaRusso NF. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. Am J Physiol. 1998 Oct; 275 (4):G749-57
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de Groen PC, Vroman B, Laakso K, LaRusso NF. Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions. In Vitro Cell Dev Biol Anim. 1998 Oct; 34 (9):704-10
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Celli A, Que FG, Gores GJ, LaRusso NF. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 1998 Oct 1; 275 (4):G749-G757
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Ueno Y, Ishii M, Takahashi S, Igarashi T, Toyota T, LaRusso NF. Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II. Lab Invest. 1998 May; 78(5):629-37.
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Ludwig J, Ritman EL, LaRusso NF, Sheedy PF, Zumpe G. Anatomy of the human biliary system studied by quantitative computer-aided three-dimensional imaging techniques. Hepatology. 1998 Apr; 27(4):893-9.
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Alpini G, Glaser SS, Ueno Y, Pham L, Podila PV, Caligiuri A, LeSage G, LaRusso NF. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol Gastrointest Liver Physiol. 1998 Apr 1; 274 (4):G767-G775
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Tietz P, Levine S, Holman R, Fretham C, LaRusso NF. Characterization of apical and basolateral plasma membrane domains derived from cultured rat cholangiocytes. Anal Biochem. 1997 Dec 15; 254(2):192-9.
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Marotta PJ, LaRusso NF, Wiesner RH. Sclerosing cholangitis. Baillieres Clin Gastroenterol. 1997 Dec; 11 (4):781-800
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Lazaridis KN, Pham L, Tietz P, Marinelli RA, deGroen PC, Levine S, Dawson PA, LaRusso NF. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J Clin Invest. 1997 Dec 1; 100 (11):2714-21
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Loftus EV Jr, Sandborn WJ, Lindor KD, Larusso NF. Interactions between chronic liver disease and inflammatory bowel disease. Inflamm Bowel Dis. 1997 Winter; 3 (4):288-302
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Marinelli RA, LaRusso NF. Aquaporin water channels in liver: their significance in bile formation. Hepatology. 1997 Nov; 26(5):1081-4.
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Schlenker T, Romac JM, Sharara AI, Roman RM, Kim SJ, LaRusso N, Liddle RA, Fitz JG. Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. Am J Physiol. 1997 Nov; 273(5 Pt 1):G1108-17.
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LaRusso N. Search for medical treatment for primary biliary cirrhosis. Lancet. 1997 Oct 11; 350(9084):1046.
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Harnois DM, Que FG, Celli A, LaRusso NF, Gores GJ. Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line. Hepatology. 1997 Oct; 26 (4):884-90
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Harnois DM, Gores GJ, Ludwig J, Steers JL, LaRusso NF, Wiesner RH. Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer? J Hepatol. 1997 Sep; 27 (3):512-6
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Marinelli RA, Pham L, Agre P, LaRusso NF. Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. J Biol Chem. 1997 May 16; 272 (20):12984-8
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Lazaridis KN, Pham L, Vroman B, de Groen PC, LaRusso NF. Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. Am J Physiol. 1997 May; 272 (5 Pt 1):G1168-74
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Alpini G, Ulrich C, Roberts S, Phillips JO, Ueno Y, Podila PV, Colegio O, LeSage GD, Miller LJ, LaRusso NF. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol. 1997 Feb; 272 (2 Pt 1):G289-97
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Loftus EV, Sandborn WJ, Lindor KD, LaRusso NF. Hepatobiliary disease in inflammatory bowel disease. Inflamm Bowel Dis. 1997; 3:288-302.
Roberts SK, Ludwig J, Larusso NF, Larusso NF. The pathobiology of biliary epithelia. Gastroenterology. 1997 Jan; 112 (1):269-79
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Que FG, Gores GJ, LaRusso NF. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. Am J Physiol. 1997 Jan; 272 (1 Pt 1):G106-15
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Wiesner RH, Porayko MK, Hay JE, LaRusso NF, Steers JL, Krom RAF, Dickson ER. Liver transplantation for primary sclerosing cholangitis: impact of risk factors on outcome. Liver Transpl Surg. 1996 Sep; 2(Suppl 1):99-108.
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Kartheuser AH, Dozois RR, LaRusso NF, Wiesner RH, Ilstrup DM, Schleck CD. Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: ileal pouch-anal anastomosis versus Brooke ileostomy. Mayo Clin Proc. 1996 Aug; 71 (8):748-56
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Alpini G, Roberts S, Kuntz SM, Ueno Y, Gubba S, Podila PV, LeSage G, LaRusso NF. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology. 1996 May; 110 (5):1636-43
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Marinelli RA, Larusso NF. Solute and water transport pathways in cholangiocytes. Semin Liver Dis. 1996 May; 16(2):221-9.
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Yano M, Marinelli RA, Roberts SK, Balan V, Pham L, Tarara JE, de Groen PC, LaRusso NF. Rat hepatocytes transport water mainly via a non-channel-mediated pathway. J Biol Chem. 1996 Mar 22; 271 (12):6702-7
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Lindor KD, Jorgensen RA, Anderson ML, Gores GJ, Hofmann AF, LaRusso NF. Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study. Am J Gastroenterol. 1996 Mar; 91(3):511-5.
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Penna C, Dozois R, Tremaine W, Sandborn W, Tremaine W, Sandborn W, LaRusso N, Schleck C, LaRusso N, Ilstrup D. Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. Gut. 1996 Feb; 38 (2):234-9
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Ueno Y, Phillips JO, Ludwig J, Lichtman SN, LaRusso NF. Development and characterization of a rodent model of immune-mediated cholangitis. Proc Natl Acad Sci U S A. 1996 Jan 9; 93 (1):216-20
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LaRusso NF. Morphology, physiology, and biochemistry of biliary epithelia. Toxicol Pathol. 1996 Jan-Feb; 24: (1)84-9.
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Vroman B, LaRusso NF. Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. Lab Invest. 1996 Jan; 74(1):303-13.
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Tietz PS, Holman RT, Miller LJ, LaRusso NF. Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains. Biochemistry. 1995 Nov 28; 34 (47):15436-43
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Myers BM, Tietz PS, Tarara JE, LaRusso NF. Dynamic measurements of the acute and chronic effects of lysosomotropic agents on hepatocyte lysosomal pH using flow cytometry. Hepatology. 1995 Nov; 22(5):1519-26.
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Balan V, LaRusso NF. Hepatobiliary disease in inflammatory bowel disease. Gastroenterol Clin North Am. 1995 Sep; 24(3):647-69.
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Nakano A, Marks DL, Tietz PS, de Groen PC, LaRusso NF. Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes. Hepatology. 1995 Jul; 22(1):262-6.
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Tietz PS, Alpini G, Pham LD, Larusso NF. Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. Am J Physiol. 1995 Jul; 269(1 Pt 1):G110-8.
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Tan CK, Podila PV, Taylor JE, Nagorney DM, Wiseman GA, Gores GJ, LaRusso NF. Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition. Gastroenterology. 1995 Jun; 108 (6):1908-16
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Jorgensen RA, Lindor KD, Sartin JS, LaRusso NF, Wiesner RH. Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis. J Clin Gastroenterol. 1995 Apr; 20 (3):215-9
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Marks DL, LaRusso NF, McNiven MA. Isolation of the microtubule-vesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids. Gastroenterology. 1995 Mar; 108 (3):824-33
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Roberts SK, Yano M, Ueno Y, Pham L, Alpini G, Agre P, LaRusso NF. Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. Proc Natl Acad Sci U S A. 1994 Dec 20; 91 (26):13009-13
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Roberts SK, Larusso NF. Pathobiology of biliary epithelia. Curr Opin Gastroenterol. 1994 Sep; 10:526-533.
Alpini G, Phillips JO, Vroman B, LaRusso NF. Recent advances in the isolation of liver cells. Hepatology. 1994 Aug; 20(2):494-514.
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Ueno Y, LaRusso NF. Primary sclerosing cholangitis. J Gastroenterol. 1994 Aug; 29 (4):531-43
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Alpini G, Ulrich CD 2nd, Phillips JO, Pham LD, Miller LJ, LaRusso NF. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol. 1994 May; 266 (5 Pt 1):G922-8
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Janas RM, Marks DL, LaRusso NF. Purification and partial characterization of a heat-resistant, cytosolic neuropeptidase from rat liver. Biochem Biophys Res Commun. 1994 Jan 28; 198(2):574-81.
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Myers BM, Prendergast FG, Holman R, Kuntz SM, Larusso NF. Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. Gastroenterology. 1993 Dec; 105(6):1814-23.
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Roberts SK, Kuntz SM, Gores GJ, LaRusso NF. Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts. Proc Natl Acad Sci U S A. 1993 Oct 1; 90 (19):9080-4
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Nichols JC, Gores GJ, LaRusso NF, Wiesner RH, Nagorney DM, Ritts RE Jr. Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis. Mayo Clin Proc. 1993 Sep; 68 (9):874-9
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Kartheuser AH, Dozois RR, Wiesner RH, LaRusso NF, Ilstrup DM, Schleck CD. Complications and risk factors after ileal pouch-anal anastomosis for ulcerative colitis associated with primary sclerosing cholangitis. Ann Surg. 1993 Apr; 217 (4):314-20
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Sandborn WJ, Wiesner RH, Tremaine WJ, Larusso NF, Larusso NF. Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin. Gut. 1993 Feb; 34 (2):242-6
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Larusso NF, Link AM. Tempora mutantur, nos et mutamur in illis!. Gastroenterology. 1993; 104:3-5.
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Larusso NF, Link AM. Gaining acceptance to gastroenterology: how the review process works. Gastroenterology. 1993; 104:1252-1254.
Kartheuser AH, Dozois RR, Wiesner RH, La Russo NF, Ilstrup DM, Schleck CD. [Complications and risk factors of ileo-anal anastomosis with reservoir for ulcero-hemorrhagic rectocolitis associated with primary sclerosing cholangitis]. [French]. Ann Chir. 1993; 47(10):1000-8.
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Dickson ER, Murtaugh PA, Wiesner RH, Grambsch PM, Fleming TR, Ludwig J, LaRusso NF, Malinchoc M, Chapman RW, Kaplan MM. Primary sclerosing cholangitis: refinement and validation of survival models. Gastroenterology. 1992 Dec; 103 (6):1893-901
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Wiesner RH, Porayko MK, Dickson ER, Gores GJ, LaRusso NF, Hay JE, Wahlstrom HE, Krom RA. Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology. 1992 Nov; 16(5):1290-9.
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Janas RM, Marks DL, LaRusso NF. An aluminum silicate binding assay for quantitation of degradation of cholecystokinin octapeptide and other short peptides. Anal Biochem. 1992 Oct; 206 (1):6-11
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Kato A, Gores GJ, LaRusso NF. Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism. J Biol Chem. 1992 Aug 5; 267 (22):15523-9
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Hoerl BJ, Vroman BT, Kasperbauer JL, LaRusso NF, Scott RE. Biological characteristics of primary cultures of human gallbladder epithelial cells. Lab Invest. 1992 Feb; 66(2):243-50.
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Link AM, Larusso NF. Further, faster, and (hopefully) better!. Gastroenterology. 1992; 103:1099-1101.
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Craig DA, MacCarty RL, Wiesner RH, Grambsch PM, LaRusso NF. Primary sclerosing cholangitis: value of cholangiography in determining the prognosis. AJR Am J Roentgenol. 1991 Nov; 157 (5):959-64
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Myers BM, Prendergast FG, Holman R, Kuntz SM, LaRusso NF. Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J Clin Invest. 1991 Oct; 88 (4):1207-15
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Hay JE, Lindor KD, Wiesner RH, Dickson ER, Krom RA, LaRusso NF. The metabolic bone disease of primary sclerosing cholangitis. Hepatology. 1991 Aug; 14: (2)257-61.
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Marks DL, Kost LJ, Kuntz SM, Romero JC, LaRusso NF. Hepatic processing of recombinant human renin: mechanisms of uptake and degradation. Am J Physiol. 1991 Aug; 261 (2 Pt 1):G349-58
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Duerr RH, Targan SR, Landers CJ, LaRusso NF, Lindsay KL, Wiesner RH, Shanahan F. Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology. 1991 May; 100(5 Pt 1):1385-91.
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Porayko MK, LaRusso NF, Wiesner RH. Primary sclerosing cholangitis: a progressive disease? Semin Liver Dis. 1991 Feb; 11(1):18-25.
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Rosen CB, Nagorney DM, Wiesner RH, Coffey RJ Jr, LaRusso NF. Cholangiocarcinoma complicating primary sclerosing cholangitis. Ann Surg. 1991 Jan; 213 (1):21-5
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Wiesner RH, Larusso NF. Advances in primary sclerosing cholangitis. Contemp Gastroenterol. 1991; 4:54-61.
Lindor KD, Wiesner RH, Colwell LJ, Steiner B, Beaver S, LaRusso NF. The combination of prednisone and colchicine in patients with primary sclerosing cholangitis. Am J Gastroenterol. 1991 Jan; 86(1):57-61.
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LaRusso NF, Ishii M, Vroman BT. The ins and outs of membrane movement in biliary epithelia. Trans Am Clin Climatol Assoc. 1991; 102:245-58; discussion 258-9
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Tietz PS, Yamazaki K, LaRusso NF. Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. Biochem Pharmacol. 1990 Sep 15; 40 (6):1419-21
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Kost LJ, Gores GJ, Sayles JM, Miller LJ, Lemasters JJ, Herman B, LaRusso NF. Lack of metabolic effects of cholecystokinin on hepatocytes. Hepatology. 1990 Aug; 12 (2):301-5
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Lindor KD, Wiesner RH, MacCarty RL, Ludwig J, LaRusso NF. Advances in primary sclerosing cholangitis. Am J Med. 1990 Jul; 89 (1):73-80
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Hunter EB, Powers SP, Kost LJ, Pinon DI, Miller LJ, LaRusso NF. Physicochemical determinants in hepatic extraction of small peptides. Hepatology. 1990 Jul; 12 (1):76-82
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Porayko MK, Wiesner RH, LaRusso NF, Ludwig J, MacCarty RL, Steiner BL, Twomey CK, Zinsmeister AR. Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease. Gastroenterology. 1990 Jun; 98 (6):1594-602
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Ishii M, Vroman B, LaRusso NF. Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. Gastroenterology. 1990 May; 98 (5 Pt 1):1284-91
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Nakano A, Tietz PS, LaRusso NF. Circadian rhythms of biliary protein and lipid excretion in rats. Am J Physiol. 1990 May; 258 (5 Pt 1):G653-9
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Ishii M, Vroman B, LaRusso NF. Fluid-phase endocytosis by intrahepatic bile duct epithelial cells isolated from normal rat liver. J Histochem Cytochem. 1990 Apr; 38: (4)515-24.
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LaRusso NF, Ishii M, Vroman BT. The ins and outs of membrane movement in biliary epithelia. Transactions of the American Clinical & Climatological Association. 1990; 102:245-58, discussion 258-9.
de Groen PC, LeSage GD, Tietz PS, LaRusso NF. Purification and immunological quantification of rat liver lysosomal glycosidases. Biochem J. 1989 Nov 15; 264 (1):115-23
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Ishii M, Vroman B, LaRusso NF. Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. Gastroenterology. 1989 Nov; 97 (5):1236-47
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Yamazaki K, LaRusso NF. The liver and intracellular digestion: how liver cells eat! Hepatology. 1989 Nov; 10 (5):877-86
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Wiesner RH, Grambsch PM, Dickson ER, Ludwig J, MacCarty RL, Hunter EB, Fleming TR, Fisher LD, Beaver SJ, LaRusso NF. Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis. Hepatology. 1989 Oct; 10 (4):430-6
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Gores GJ, Kost LJ, Miller LJ, LaRusso NF. Processing of cholecystokinin by isolated liver cells. Am J Physiol. 1989 Aug; 257 (2 Pt 1):G242-8
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Gerecht WB, Henry NK, Hoffman WW, Muller SM, LaRusso NF, Rosenblatt JE, Wilson WR. Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis. Arch Intern Med. 1989 Jun; 149(6):1279-84.
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Cangemi JR, Wiesner RH, Beaver SJ, Ludwig J, MacCarty RL, Dozois RR, Zinsmeister AR, LaRusso NF. Effect of proctocolectomy for chronic ulcerative colitis on the natural history of primary sclerosing cholangitis. Gastroenterology. 1989 Mar; 96(3):790-4.
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Gross JB Jr, Myers BM, Kost LJ, Kuntz SM, LaRusso NF. Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload. J Clin Invest. 1989 Jan; 83 (1):30-9
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Hay JE, Wiesner RH, Shorter RG, LaRusso NF, Baldus WP. Primary sclerosing cholangitis and celiac disease. A novel association. Ann Intern Med. 1988 Nov 1; 109 (9):713-7
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Balasubramaniam K, Wiesner RH, LaRusso NF. Primary sclerosing cholangitis with normal serum alkaline phosphatase activity. Gastroenterology. 1988 Nov; 95 (5):1395-8
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LaRusso NF, Wiesner RH, Ludwig J, MacCarty RL, Beaver SJ, Zinsmeister AR. Prospective trial of penicillamine in primary sclerosing cholangitis. Gastroenterology. 1988 Oct; 95 (4):1036-42
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Sewell RB, Grinpukel SA, Zinsmeister AR, LaRusso NF. Pharmacologic perturbation of rat liver lysosomes: effects on release of lysosomal enzymes and of lipids into bile. Gastroenterology. 1988 Oct; 95(4):1088-98.
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Ludwig J, Wiesner RH, LaRusso NF. Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. J Hepatol. 1988 Oct; 7 (2):193-9
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Yamazaki K, Powers SP, LaRusso NF. Biliary proteins: assessment of quantitative techniques and comparison in gallstone and nongallstone subjects. J Lipid Res. 1988 Aug; 29 (8):1055-63
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Wiesner RH, Grambsch P, LaRusso NF, Dickson ER. Is primary sclerosing cholangitis a progressive disease or not? Hepatology. 1988 Jul-Aug; 8 (4):970-2
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Brandt DJ, MacCarty RL, Charboneau JW, LaRusso NF, Wiesner RH, Ludwig J. Gallbladder disease in patients with primary sclerosing cholangitis. AJR Am J Roentgenol. 1988 Mar; 150: (3)571-4.
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Yamazaki K, LaRusso NF. Electropermeabilization: getting inside the cell to study autophagy. Hepatology. 1988 Mar-Apr; 8 (2):418-9
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Keiser JA, Romero JC, Kost LJ, LaRusso NF. Hepatic extraction of renin: quantitation and characterization in the isolated perfused rat liver. Hepatology. 1987 Nov-Dec; 7 (6):1254-61
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Lindor KD, Wiesner RH, LaRusso NF. Recent advances in the management of primary sclerosing cholangitis. Semin Liver Dis. 1987 Nov; 7(4):322-7.
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Czaja MJ, Weiner FR, Schwarzenberg SJ, Sternlieb I, Scheinberg IH, Van Thiel DH, LaRusso NF, Giambrone MA, Kirschner R, Koschinsky ML. Molecular studies of ceruloplasmin deficiency in Wilson's disease. J Clin Invest. 1987 Oct; 80(4):1200-4.
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Coffey RJ Jr, Kost LJ, Moses HL, Larusso NF. Hepatic processing of transforming growth factor B in the rat uptake, metabolism, and biliary excretion. J Clin Invest. 1987 Sep; 80:750-757.
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Lindor KD, Wiesner RH, LaRusso NF, Homburger HA. Enhanced autoreactivity of T-lymphocytes in primary sclerosing cholangitis. Hepatology. 1987 Sep-Oct; 7 (5):884-8
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Lindor KD, Wiesner RH, Katzmann JA, LaRusso NF, Beaver SJ. Lymphocyte subsets in primary sclerosing cholangitis. Dig Dis Sci. 1987 Jul; 32(7):720-5.
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Kawamoto T, Mao SJ, LaRusso NF. Biliary excretion of apolipoprotein B by the isolated perfused rat liver. Relationship to receptor-mediated uptake of human low-density lipoprotein and biliary lipid secretion. Gastroenterology. 1987 May; 92(5 Pt 1):1236-42.
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Kawamoto T, Mao SJ, LaRusso NF. Biliary excretion of apolipoprotein B by the isolated perfused rat liver. Relationship to receptor-mediated uptake of human low-density lipoprotein and biliary lipid secretion. Gastroenterology. 1987 May; 92 (5 Pt 1):1236-42
Perkins JD, Wiesner RH, Banks PM, LaRusso NF, Krom RA. Immunohistologic labeling of infiltrating T lymphocytes in hepatic allografts: a rejection indicator. Transplant Proc. 1987 Feb; 19(1 Pt 3):2474-5.
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Perkins JD, Wiesner RH, Banks PM, LaRusso NF, Ludwig J, Krom RA. Immunohistologic labeling as an indicator of liver allograft rejection. Transplantation. 1987 Jan; 43(1):105-8.
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Ludwig J, MacCarty RL, LaRusso NF, Krom RA, Wiesner RH. Intrahepatic cholangiectases and large-duct obliteration in primary sclerosing cholangitis. Hepatology. 1986 Jul-Aug; 6(4):560-8.
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Cockerill FR 3rd, Hurley DV, Malagelada JR, LaRusso NF, Edson RS, Katzmann JA, Banks PM, Wiltsie JC, Davis JP, Lack EE Jr. Polymicrobial cholangitis and Kaposi's sarcoma in blood product transfusion-related acquired immune deficiency syndrome. Am J Med. 1986 Jun; 80(6):1237-41.
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Gores GJ, Kost LJ, LaRusso NF. The isolated perfused rat liver: conceptual and practical considerations. Hepatology. 1986 May-Jun; 6(3):511-7.
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Larusso NF. Lysosomes and the vacuolar apparatus: the gastrointestinal tract of the cell. Viewpoints Dig Dis. 1986 May; 18:9-12.
Gores GJ, LaRusso NF, Miller LJ. Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanism of hepatic extraction. Am J Physiol. 1986 Mar; 250(3 Pt 1):G344-9.
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Gores GJ, Miller LJ, LaRusso NF. Hepatic processing of cholecystokinin peptides. II. Cellular metabolism, transport, and biliary excretion. Am J Physiol. 1986 Mar; 250(3 Pt 1):G350-6.
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Wiesner RH, LaRusso NF, Dozois RR, Beaver SJ. Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis. Gastroenterology. 1986 Feb; 90(2):316-22.
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LeSage GD, Kost LJ, Barham SS, LaRusso NF. Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload. J Clin Invest. 1986 Jan; 77(1):90-7.
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May GR, Bender CE, LaRusso NF, Wiesner RH. Nonoperative dilatation of dominant strictures in primary sclerosing cholangitis. AJR Am J Roentgenol. 1985 Nov; 145(5):1061-4.
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Gross JB Jr, Ludwig J, Wiesner RH, McCall JT, LaRusso NF. Abnormalities in tests of copper metabolism in primary sclerosing cholangitis. Gastroenterology. 1985 Aug; 89(2):272-8.
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Wee A, Ludwig J, Coffey RJ Jr, LaRusso NF, Wiesner RH. Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hum Pathol. 1985 Jul; 16(7):719-26.
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MacCarty RL, LaRusso NF, May GR, Bender CE, Wiesner RH, King JE, Coffey RJ. Cholangiocarcinoma complicating primary sclerosing cholangitis: cholangiographic appearances. Radiology. 1985 Jul; 156(1):43-6.
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Allen MJ, Borody TJ, Bugliosi TF, May GR, Larusso NF, Thistle JL. Rapid dissolution of gallstones by methyl tert-butyl ether. N Engl J Med. 1985 Jan 24; 312:217-220.
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Allen MJ, Borody TJ, Bugliosi TF, May GR, LaRusso NF, Thistle JL. Cholelitholysis using methyl tertiary butyl ether. Gastroenterology. 1985 Jan; 88(1 Pt 1):122-5.
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Wiesner RH, LaRusso NF, Ludwig J, Dickson ER. Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology. 1985 Jan; 88(1 Pt 1):108-14.
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Tietz PS, Thistle JL, Miller LJ, LaRusso NF. Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography. J Chromatogr. 1984 Dec 12; 336(2):249-57.
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LaRusso NF. Proteins in bile: how they get there and what they do. Am J Physiol. 1984 Sep; 247(3 Pt 1):G199-205.
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Kibe A, Holzbach RT, LaRusso NF, Mao SJ. Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile. Science. 1984 Aug 3; 225(4661):514-6.
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Larusso NF, Wiesner RH, Ludwig J, MacCarty RL. Primary sclerosing cholangitis. N Engl J Med. 1984 Apr 5; 310:899-903.
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Ludwig J, Czaja AJ, Dickson ER, LaRusso NF, Wiesner RH. Manifestations of nonsuppurative cholangitis in chronic hepatobiliary diseases: morphologic spectrum, clinical correlations and terminology. Liver. 1984 Apr; 4(2):105-16.
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Sewell RB, Grinpukel SA, LaRusso NF, Barham SS. Role of hepatocyte lysosomes in biliary excretory processes. Int Congr Ser. 1984; 660:267-271.
Sewell RB, Barham SS, Zinsmeister AR, LaRusso NF. Microtubule modulation of biliary excretion of endogenous and exogenous hepatic lysosomal constituents. Am J Physiol. 1984 Jan; 246(1 Pt 1):G8-15.
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Dickson ER, LaRusso NF, Wiesner RH. Primary sclerosing cholangitis. Hepatology. 1984 Jan-Feb; 4(1 Suppl):33S-35S.
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Mihas AA, Volanakis JE, Schrohenloher RE, Mihas TA, Bodenheimer HC Jr, Larusso NF, Thayer WR Jr, Charland C, Staples PJ, Ludwig J, Roggendorf M, Deinhardt F, Frosner GG. Correspondence. Circulating immune complexes in primary sclerosing cholangitis Hepatology. 1984; 4: (2)351-4.
Sewell RB, Barham SS, LaRusso NF. Effect of chloroquine on the form and function of hepatocyte lysosomes. Morphologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. Gastroenterology. 1983 Nov; 85(5):1146-53.
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Quigley EM, LaRusso NF, Ludwig J, MacSween RN, Birnie GG, Watkinson G. Familial occurrence of primary sclerosing cholangitis and ulcerative colitis. Gastroenterology. 1983 Nov; 85(5):1160-5.
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Novikoff PM, La Russo NF, Novikoff AB, Stockert RJ, Yam A, Le Sage GD. Immunocytochemical localization of lysosomal beta-galactosidase in rat liver. J Cell Biol. 1983 Nov; 97(5 Pt 1):1559-65.
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Sewell RB, Barham SS, LaRusso NF. Effect of chloroquine on the form and function of hepatocyte lysosomes. Morphologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. Gastroenterology. 1983 Nov; 85 (5):1146-53
MacCarty RL, LaRusso NF, Wiesner RH, Ludwig J. Primary sclerosing cholangitis: findings on cholangiography and pancreatography. Radiology. 1983 Oct; 149(1):39-44.
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Nagorney DM, LaRusso NF, Dozois RR. Development and application of methodology for assessing the role of lysosomes in experimental ulcerogenesis in the guinea pig. Gastroenterology. 1983 Sep; 85(3):548-56.
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Danielson KS, Sheedy PF 2nd, Stephens DH, Hattery RR, LaRusso NF. Computed tomography and peritoneoscopy for detection of liver metastases: review of Mayo Clinic experience. J Comput Assist Tomogr. 1983 Apr; 7(2):230-4.
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Sewell RB, Mao SJ, Kawamoto T, LaRusso NF. Apolipoproteins of high, low, and very low density lipoproteins in human bile. J Lipid Res. 1983 Apr; 24(4):391-401.
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Larusso NF, Wiesner RH, Ludwig J. Recent advances in the diagnosis and management of primary sclerosing cholangitis. Curr Concepts Gastroenterol. 1983 Mar/Apr; 2:6-9.
Bodenheimer HC Jr, LaRusso NF, Thayer WR Jr, Charland C, Staples PJ, Ludwig J. Elevated circulating immune complexes in primary sclerosing cholangitis. Hepatology. 1983 Mar-Apr; 3(2):150-4.
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LaRusso NF, Thistle JL. Effect of litholytic bile acids on cholesterol absorption in gallstone patients. Gastroenterology. 1983 Feb; 84(2):265-71.
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Ludwig J, Dyck PJ, LaRusso NF. Xanthomatous neuropathy of liver. Hum Pathol. 1982 Nov; 13(11):1049-51.
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Malchow-Moller A, Arffmann S, Larusso NF, Krag E. Enzymatic determination of total 3 alpha-hydroxy bile acids in faeces. Validation in healthy subjects of a rapid method suitable for clinical routine purpose. Scand J Gastroenterol. 1982 Apr; 17(3):331-3.
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Sama C, LaRusso NF, Lopez del Pino V, Thistle JL. Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers. Gastroenterology. 1982 Mar; 82(3):515-25.
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LaRusso NF, Kost LJ, Carter JA, Barham SS. Triton WR-1339, a lysosomotropic compound, is excreted into bile and alters the biliary excretion of lysosomal enzymes and lipids. Hepatology. 1982 Mar-Apr; 2(2):209-15.
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Thistle JL, Larusso NF, Hofmann AF, Carlson GL, Ott BJ. Differing effects of ursodeoxycholic of chenodeoxycholic acid on biliary cholesterol saturation and bile acid metabolism in man: a dose- response study. Dig Dis Sci. 1982 Feb; 27:161-168.
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Ludwig J, Wiesner RH, LaRusso NF. Focal dilatation of intrahepatic bile ducts (Caroli's disease), cholangiocarcinoma, and sclerosis of extrahepatic bile ducts: a case report. J Clin Gastroenterol. 1982 Feb; 4(1):53-7.
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Sama C, LaRusso NF. Effect of deoxycholic, chenodeoxycholic, and cholic acids on intestinal absorption of cholesterol in humans. Mayo Clin Proc. 1982 Jan; 57(1):44-50.
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Ludwig J, Barham SS, LaRusso NF, Elveback LR, Wiesner RH, McCall JT. Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hepatology. 1981 Nov-Dec; 1(6):632-40.
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LaRusso NF, Thistle JL. Ursodeoxycholic acid ingestion after ileal resection. Effect on biliary bile acid and lipid composition. Dig Dis Sci. 1981 Aug; 26(8):705-9.
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Lopez del Pino VH, LaRusso NF. Dissociation of bile flow and biliary lipid secretion from biliary lysosomal enzyme output in experimental cholestasis. J Lipid Res. 1981 Feb; 22(2):229-35.
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Larusso NF. Pathogenesis of gallstones, including predisposing factors. Pract Gastroenterol. 1981; 5:21-31.
Wiesner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology. 1980 Aug; 79(2):200-6.
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LaRusso NF, Dickson ER, Pineda AA. Plasmaperfusion and studies of copper metabolism in benign recurrent cholestasis: novel procedures in a rare syndrome. Mayo Clin Proc. 1980 Jul; 55(7):450-4.
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Thistle JL, Carlson GL, Hofmann AF, Larusso NF, MacCarty RL, Flynn GL, Higuchi WI, Babayan VK. Monoctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application. Gastroenterology. 1980 May; 78:1016-1022.
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Larusso NF, Fowler S. Coordinate secretion of acid hydrolases in rat bile: hepatocyte exocytosis of lysosomal protein? J Clin Invest. 1979 Oct; 64:948-954.
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Belobaba DTE, Carlson GL, Larusso NF. A simple method for simultaneous specific activity measurements in a mixture of radiolabeled bile acids. J Chromatogr. 1979; 172:410-416.
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Schalm SW, LaRusso NF, Hofmann AF, Hoffman NE, van Berge-Henegouwen GP, Korman MG. Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid. Gut. 1978 Nov; 19(11):1006-14.
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LaRusso NF, Hoffman NE, Korman MG, Hofmann AF, Cowen AE. Determinants of fasting and postprandial serum bile acid levels in healthy man. Am J Dig Dis. 1978 May; 23(5):385-91.
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LaRusso NF, Lindmark DG, Muller M. Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat. Biochem Pharmacol. 1978; 27(18):2247-54.
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Larusso NF, Tomasz M, Kaplan D, Muller M. Absence of strand breaks in DNA treated with metronidazole. Antimicrob Agents Chemother. 1978; 13:19-24.
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van Berge Henegouwen GP, Tangedahl TN, Hofmann AF, Northfield TC, LaRusso NF, McCall JT. Biliary secretion of copper in healthy man. Quantitation by an intestinal perfusion technique. Gastroenterology. 1977 Jun; 72(6):1228-31.
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LaRusso NF, Szczepanik PA, Hofmann AF. Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. Gastroenterology. 1977 Jan; 72(1):132-40.
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Larusso NF, Tomasz M, Muller M, Lipman R. In vitro interaction of metronidazole with nucleic acid. Mol Pharmacol. 1977; 13:872-882.
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LaRusso NF, Summerskill WH, McCall JT. Abnormalities of chemical tests for copper metabolism in chronic active liver disease: differentiation from Wilson's disease. Gastroenterology. 1976 May; 70(5 PT.1):653-5.
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Hoffman NE, Larusso NF, Hofmann AF. Sampling intestinal content with a sequestering capsule. A noninvasive technique for determining bile acid kinetics in man. Mayo Clin Proc. 1976 Mar; 51(3):171-5.
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LaRusso NF, Hoffman NE, Hofmann AF, Northfield TC, Thistle JL. Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients. Gastroenterology. 1975 Dec; 69(6):1301-14.
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LaRusso NF, McGill DB. Surreptitious laxative ingestion. Delayed recognition of a serious condition: a case report. Mayo Clin Proc. 1975 Dec; 50(12):706-8.
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LaRusso NF, Hoffman NE, Hofmann AF, Korman MG. Validity and sensitivity of an intravenous bile acid tolerance test in patients with liver disease. N Engl J Med. 1975 Jun 5; 292(23):1209-14.
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Korman MG, LaRusso NF, Hoffman NE, Hofmann AF. Development of an intravenous bile acid tolerance test. Plasma disappearance of cholylglycine in health. N Engl J Med. 1975 Jun 5; 292(23):1205-9.
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Northfield TC, LaRusso NF, Hofmann AF, Thistle JL. Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects. Gut. 1975 Jan; 16(1):12-7.
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Larusso NF, Hoffman NE, Hofmann AF. Validity of using 2,4-h-labeled bile acids to study bile acid kinetics in man. J Lab Clin Med. 1974 Nov; 84:759-765.
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LaRusso NF, Korman MG, Hoffman NE, Hofmann AF. Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. N Engl J Med. 1974 Oct 3; 291(14):689-92.
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Hoffman NE, LaRusso NF, Hofmann AF. An improved method for faecal collection: the faecal field-kit. Lancet. 1973 Jun 23; 1(7817):1422-3.
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Nicholas F. LaRusso, M.D.

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