Publications

1. Sun ND, Carr AR, Krogman EN, Chawla Y, Zhong J, Guttormson MC, Chan M, Hsu MA, Dong H, Bogunovic D, Pandey A, Rogers LM, Ting AT. TBK1 and IKKepsilon protect target cells from IFNgamma-mediated T cell killing via an inflammatory apoptotic mechanism. bioRxiv. 2024 Aug 8 Epub 2024 Aug 08
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2. Chen L, He Z, Reis BS, Gelles JD, Chipuk JE, Ting AT, Spicer JA, Trapani JA, Furtado GC, Lira SA. IFN-gamma(+) cytotoxic CD4(+) T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40. Cell Mol Immunol. 2022 Jul; 19 (7):777-790 Epub 2022 Apr 25
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3. Chun N, Ang RL, Chan M, Fairchild RL, Baldwin WM 3rd, Horwitz JK, Gelles JD, Chipuk JE, Kelliher MA, Pavlov VI, Li Y, Homann D, Heeger PS, Ting AT. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI Insight. 2021 Dec 22; 6 (24)
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4. Ang RL, Chan M, Legarda D, Sundberg JP, Sun SC, Gillespie VL, Chun N, Heeger PS, Xiong H, Lira SA, Ting AT. Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death. Proc Natl Acad Sci U S A. 2021 Dec 14; 118 (50)
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5. Taft J, Markson M, Legarda D, Patel R, Chan M, Malle L, Richardson A, Gruber C, Martin-Fernandez M, Mancini GMS, van Laar JAM, van Pelt P, Buta S, Wokke BHA, Sabli IKD, Sancho-Shimizu V, Chavan PP, Schnappauf O, Khubchandani R, Cuceoglu MK, Ozen S, Kastner DL, Ting AT, Aksentijevich I, Hollink IHIM, Bogunovic D. Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell. 2021 Aug 19; 184 (17):4447-4463.e20 Epub 2021 Aug 06
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6. Xu X, Kalac M, Markson M, Chan M, Brody JD, Bhagat G, Ang RL, Legarda D, Justus SJ, Liu F, Li Q, Xiong H, Ting AT. Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL). Cell Death Dis. 2020 Feb 5; 11 (2):94 Epub 2020 Feb 05
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7. Gelles JD, Mohammed JN, Santos LC, Legarda D, Ting AT, Chipuk JE. Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms. Dev Cell. 2019 Oct 21; 51 (2):277-291.e4 Epub 2019 Sept 26
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8. Priem D, Devos M, Druwe S, Martens A, Slowicka K, Ting AT, Pasparakis M, Declerq W, Vandenabeele P, van Loo G, Bertrand MJM. A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell Death Dis. 2019 Sep 18; 10 (10):692 Epub 2019 Sept 18
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9. Ang RL, Ting AT. Tumor necrosis factor-driven cell death in donor organ as a barrier to immunological tolerance. Curr Opin Organ Transplant. 2019 Feb; 24 (1):12-19
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10. Ang RL, Chan M, Ting AT. Ripoptocide - A Spark for Inflammation. Front Cell Dev Biol. 2019; 7:163 Epub 2019 Aug 13
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11. von Massenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, Ousingsawat J, Ang RL, Weinberg JM, Sanz AB, Ortiz A, Zierleyn A, Becker JU, Baratte B, Desban N, Bach S, Schiessl IM, Nogusa S, Balachandran S, Anders HJ, Ting AT, Bleich M, Degterev A, Kunzelmann K, Bornstein SR, Green DR, Hugo C, Linkermann A. Phenytoin inhibits necroptosis. Cell Death Dis. 2018 Mar 2; 9 (3):359 Epub 2018 Mar 02
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12. Garcia-Carmona Y, Ting AT, Radigan L, Athuluri Divakar SK, Chavez J, Meffre E, Cerutti A, Cunningham-Rundles C. TACI Isoforms Regulate Ligand Binding and Receptor Function. Front Immunol. 2018; 9:2125 Epub 2018 Oct 02
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13. Klei LR, Hu D, Panek R, Alfano DN, Bridwell RE, Bailey KM, Oravecz-Wilson KI, Concel VJ, Hess EM, Van Beek M, Delekta PC, Gu S, Watkins SC, Ting AT, Gough PJ, Foley KP, Bertin J, McAllister-Lucas LM, Lucas PC. MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage. Cell Rep. 2016 Sep 27; 17 (1):221-232
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14. Ting AT, Bertrand MJM. More to Life than NF-kappaB in TNFR1 Signaling. Trends Immunol. 2016 Aug; 37 (8):535-545 Epub 2016 July 13
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15. Legarda D, Justus SJ, Ang RL, Rikhi N, Li W, Moran TM, Zhang J, Mizoguchi E, Zelic M, Kelliher MA, Blander JM, Ting AT. CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN. Cell Rep. 2016 Jun 14; 15 (11):2449-61 Epub 2016 June 02
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16. Justus SJ, Ting AT. Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1. Immunol Rev. 2015 Jul; 266 (1):145-60
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17. Garcia-Carmona Y, Cols M, Ting AT, Radigan L, Yuk FJ, Zhang L, Cerutti A, Cunningham-Rundles C. Differential induction of plasma cells by isoforms of human TACI. Blood. 2015 Mar 12; 125 (11):1749-58 Epub 2015 Jan 28
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18. Manganaro L, Pache L, Herrmann T, Marlett J, Hwang Y, Murry J, Miorin L, Ting AT, Konig R, Garcia-Sastre A, Bushman FD, Chanda SK, Young JA, Fernandez-Sesma A, Simon V. Tumor suppressor cylindromatosis (CYLD) controls HIV transcription in an NF-kappaB-dependent manner. J Virol. 2014 Jul; 88 (13):7528-40 Epub 2014 Apr 23
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19. Rosebeck S, Rehman AO, Apel IJ, Kohrt D, Appert A, O'Donnell MA, Ting AT, Du MQ, Baens M, Lucas PC, McAllister-Lucas LM. The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-kappaB signaling. Oncogene. 2014 May 8; 33 (19):2520-30 Epub 2013 June 17
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20. Jianjun Yang Yang, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC 3rd, Ozato K, Sikora AG, Xiong H. T cell-derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med. 2013 Jul 1; 210 (7):1447-62
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21. Blackwell K, Zhang L, Workman LM, Ting AT, Iwai K, Habelhah H. Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IkappaB kinase activation. Mol Cell Biol. 2013 May; 33 (10):1901-15 Epub 2013 Mar 04
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22. O'Donnell MA, Ting AT. NFkappaB and ubiquitination: partners in disarming RIPK1-mediated cell death. Immunol Res. 2012 Dec; 54 (1-3):214-26
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23. O'Donnell MA, Hase H, Legarda D, Ting AT. NEMO inhibits programmed necrosis in an NFkappaB-independent manner by restraining RIP1. PLoS One. 2012; 7 (7):e41238 Epub 2012 July 26
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24. O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol. 2011 Oct 30; 13 (12):1437-42
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25. Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Mol Cancer Ther. 2011 May; 10 (5):902-14 Epub 2011 Mar 03
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26. O'Donnell MA, Ting AT. RIP1 comes back to life as a cell death regulator in TNFR1 signaling. FEBS J. 2011 Apr; 278 (6):877-87 Epub 2011 Feb 08
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27. Wu J, Zhang R, Torreggiani M, Ting A, Xiong H, Striker GE, Vlassara H, Zheng F. Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation. Am J Pathol. 2010 May; 176 (5):2163-76 Epub 2010 Apr 02
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28. O'Donnell MA, Ting AT. Chronicles of a death foretold: dual sequential cell death checkpoints in TNF signaling. Cell Cycle. 2010 Mar 15; 9 (6):1065-71
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29. Legarda-Addison D, Hase H, O'Donnell MA, Ting AT. NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ. 2009 Sep; 16 (9):1279-88 Epub 2009 Apr 17
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30. Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep. 2008 Sep; 9 (9):930-6 Epub 2008 July 18
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31. Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Eur J Immunol. 2008 May; 38 (5):1204-14
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32. Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29; 319 (5867):1189-90
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33. Legarda-Addison D, Ting AT. Negative regulation of TCR signaling by NF-kappaB2/p100. J Immunol. 2007 Jun 15; 178 (12):7767-78
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34. O'Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol. 2007 Mar 6; 17 (5):418-24 Epub 2007 Feb 15
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35. Zhao Q, Yang M, Ting AT, Logothetis DE. PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death. Channels (Austin). 2007 Jan-Feb; 1 (1):46-55 Epub 2007 Jan 29
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36. Yang M, Hase H, Legarda-Addison D, Varughese L, Seed B, Ting AT. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. J Immunol. 2005 Sep 1; 175 (5):2814-24
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37. Zhang Y, Ting AT, Marcu KB, Bliska JB. Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia. J Immunol. 2005 Jun 15; 174 (12):7939-49
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38. Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B. Large-scale screens for cDNAs with in vivo activity. Novartis Found Symp. 2005; 267:219-29; discussion 229-30
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39. Goodkin ML, Ting AT, Blaho JA. NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection. J Virol. 2003 Jul; 77(13):7261-80.
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40. He KL, Ting AT. Essential role for IKKgamma/NEMO in TCR-induced IL-2 expression in Jurkat T cells. Eur J Immunol. 2003 Jul; 33(7):1917-24.
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41. He KL, Ting AT. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol Cell Biol. 2002 Sep; 22(17):6034-45.
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42. Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. Mol Cell Biol. 1999 Aug; 19(8):5759-67.
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43. Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998 Jan 1; 391(6662):82-6.
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44. Ting AT, Pimentel-Muiños FX, Seed B. RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J. 1996 Nov 15; 15(22):6189-96.
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45. Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham RT, Leibson PJ. Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells. J Biol Chem. 1995 Jul 7; 270 (27):16415-21
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46. Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham RT, Leibson PJ. Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol. 1994 Mar 1; 152 (5):2098-104
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47. Ting AT, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ. Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med. 1992 Dec 1; 176 (6):1751-5
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48. Ting AT, Schoon RA, Abraham RT, Leibson PJ. Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis. J Biol Chem. 1992 Nov 25; 267 (33):23957-62
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49. Ting AT, Einspahr KJ, Abraham RT, Leibson PJ. Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway. J Immunol. 1991 Nov 1; 147(9):3122-7.
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50. Leiter EH, Christianson GJ, Serreze DV, Ting AT, Worthen SM. MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice. J Exp Med. 1989 Oct 1; 170(4):1243-62.
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