Publications

1. Konecny J, Misiachna A, Chvojkova M, Kleteckova L, Kolcheva M, Novak M, Prchal L, Ladislav M, Hemelikova K, Netolicky J, Hrabinova M, Kobrlova T, Karasova JZ, Pejchal J, Fibigar J, Vecera Z, Kucera T, Jendelova P, Zahumenska P, Langore E, Doderovic J, Pang YP, Vales K, Korabecny J, Soukup O, Horak M. Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects. Eur J Med Chem. 2024 Oct 18; 280:116981 [Epub ahead of print]
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2. Dougherty GW, Ostrowski LE, Nothe-Menchen T, Raidt J, Schramm A, Olbrich H, Yin W, Sears PR, Dang H, Smith AJ, Beule AG, Hjeij R, Rutjes N, Haarman EG, Maas SM, Ferkol TW, Noone PG, Olivier KN, Bracht DC, Barbry P, Zaragosi LE, Fierville M, Kliesch S, Wohlgemuth K, Konig J, George S, Loges NT, Ceppe A, Markovetz MR, Luo H, Guo T, Rizk H, Eldesoky T, Dahlke K, Boldt K, Ueffing M, Hill DB, Pang YP, Knowles MR, Zariwala MA, Omran H. Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis. Am J Respir Crit Care Med. 2024 Jul 1; 210 (1):63-76
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3. Hu C, Belur Nagaraj A, Nagaraj AB, Shimelis H, Montalban G, Lee KY, Huang H, Lumby CA, Na J, Susswein LR, Roberts ME, Marshall ML, Hiraki S, LaDuca H, Chao E, Yussuf A, Pesaran T, Neuhausen SL, Haiman CA, Kraft P, Lindstrom S, Palmer JR, Teras LR, Vachon CM, Yao S, Ong I, Nathanson KL, Weitzel JN, Boddicker N, Gnanaolivu R, Polley EC, Mer G, Cui G, Karam R, Richardson ME, Domchek SM, Yadav S, Hruska KS, Dolinsky J, Weroha SJ, Hart SN, Simard J, Masson JY, Pang YP, Couch FJ. Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C. Cancer Res. 2023 Aug 1; 83 (15):2557-2571
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4. Dai H, Peterson KL, Flatten KS, Meng XW, Venkatachalam A, Correia C, Ramirez-Alvarado M, Pang YP, Kaufmann SH. A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C. Cell Death Differ. 2023 Mar; 30(3):794-808. Epub 2022 Nov 14.
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5. Lorenzana IJ, Leske DA, Hatt SR, Dean TW, Jenewein EC, Dagi LR, Beal CJ, Pang Y, Retnasothie DV, Esposito CA, Erzurum SA, Aldrich AE, Crouch ER, Li Z, Kraker RT, Holmes JM, Cotter SA, Pediatric Eye Disease Investigator Group//Pediatric Eye Disease Investigator Group. Relationships among Clinical Factors and Patient-reported Outcome Measures in Adults with Convergence Insufficiency. Optom Vis Sci. 2022 Sep 1; 99 (9):692-701 Epub 2022 Aug 02
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6. Pang YP. How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly. Commun Chem. 2022 Jan 20; 5 (1):9
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7. Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nat Neurosci. 2022 Jan; 25 (1):26-38 Epub 2021 Dec 16
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8. Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y. Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. J Neurochem. 2021 Sep; 158 (6):1381-1393 Epub 2021 July 05
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9. Wiese EK, Hitosugi S, Loa ST, Sreedhar A, Andres-Beck LG, Kurmi K, Pang YP, Karnitz LM, Gonsalves WI, Hitosugi T. Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect. Nat Metab. 2021 Jul; 3 (7):954-968 Epub 2021 July 05
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10. McFerrin KG, Pang YP. How the water-soluble hemicarcerand incarcerates guests at room temperature decoded with modular simulations. Commun Chem. 2021 Mar 1; 4 (1):26 Epub 2021 Mar 01
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11. Dougherty GW, Mizuno K, Nothe-Menchen T, Ikawa Y, Boldt K, Ta-Shma A, Aprea I, Minegishi K, Pang YP, Pennekamp P, Loges NT, Raidt J, Hjeij R, Wallmeier J, Mussaffi H, Perles Z, Elpeleg O, Rabert F, Shiratori H, Letteboer SJ, Horn N, Young S, Strunker T, Stumme F, Werner C, Olbrich H, Takaoka K, Ide T, Twan WK, Biebach L, Grosse-Onnebrink J, Klinkenbusch JA, Praveen K, Bracht DC, Hoben IM, Junger K, Gutzlaff J, Cindric S, Aviram M, Kaiser T, Memari Y, Dzeja PP, Dworniczak B, Ueffing M, Roepman R, Bartscherer K, Katsanis N, Davis EE, Amirav I, Hamada H, Omran H. CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. Nat Commun. 2020 Nov 2; 11 (1):5520 Epub 2020 Nov 02
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12. Ye K, Meng WX, Sun H, Wu B, Chen M, Pang YP, Gao J, Wang H, Wang J, Kaufmann SH, Dai H. Characterization of an alternative BAK-binding site for BH3 peptides. Nat Commun. 2020 Jul 3; 11 (1):3301 Epub 2020 July 03
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13. Pang YP. Comment on "Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors". ACS Med Chem Lett. 2020 Jun 11; 11 (6):1063-1064 Epub 2020 May 19
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14. Hu S, Xian Y, Fan Y, Mak S, Wang J, Tang J, Pang Y, Pi R, Tsim KW, Liu F, Lin Z, Han Y. Significant combination of Abeta aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent. Eur J Pharmacol. 2020 Jun 5; 876:173065 Epub 2020 Mar 20
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15. Ke Z, Hu S, Cui W, Sun J, Zhang S, Mak S, Wang J, Tang J, Pang Y, Han Y, Tong K. Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression. Neurochem Int. 2019 Sep; 128:143-153 Epub 2019 Apr 26
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16. Block MS, Nevala WK, Pang YP, Allred JB, Strand C, Markovic SN. A pilot clinical trial testing topical resiquimod and a xenopeptide as immune adjuvants for a melanoma vaccine targeting MART-1. Melanoma Res. 2019 Aug; 29 (4):420-427
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17. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TDT, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E. Corrigendum to "Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease" [EBioMedicine 2 (2015) 294-305]. EBioMedicine. 2019 Apr; 42:532 Epub 2019 Apr 04
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18. Pang YP, Casal Moura M, Thompson GE, Nelson DR, Hummel AM, Jenne DE, Emerling D, Volkmuth W, Robinson WH, Specks U. Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors. Front Immunol. 2019; 10:2467 Epub 2019 Oct 25
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19. Pang YP, Elsbernd LR, Block MS, Markovic SN. Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens. Immunohorizons. 2018 Aug 10; 2 (7):216-225
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20. Pang YP. How fast fast-folding proteins fold in silico. Biochem Biophys Res Commun. 2017 Oct 7; 492 (1):135-139 Epub 2017 Aug 09
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21. Darras FH, Pang YP. On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity. Biochem Biophys Res Commun. 2017 Aug 5; 489 (4):451-454 Epub 2017 May 29
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22. Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y. Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis. Chem Biol Interact. 2016 Nov 25; 259 (Pt B):271-275 Epub 2016 Feb 23
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23. Pang YP. FF12MC: A revised AMBER forcefield and new protein simulation protocol. Proteins. 2016 Oct; 84 (10):1490-516 Epub 2016 July 21
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24. Pang YP. Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins. Heliyon. 2016 Sep; 2 (9):e00161 Epub 2016 Sept 20
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25. Cummins NW, Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, de Araujo Correia MCM, Sampath R, Rizza SA, O'Brien D, Yao JD, Kaufmann SH, Badley AD. Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size. J Virol. 2016 Apr; 90(8):4032-4048. Epub 2016 Mar 28.
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26. Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF. Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils. CNS Neurosci Ther. 2015 Dec; 21 (12):953-61 Epub 2015 Oct 28
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27. Pang YP. Low-mass molecular dynamics simulation for configurational sampling enhancement: More evidence and theoretical explanation. Biochem Biophys Rep. 2015 Dec; 4:126-133 Epub 2015 Sept 02
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28. Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell. 2015 Oct 1; 60 (1):21-34 Epub 2015 Sept 17
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29. Hu S, Cui W, Mak S, Xu D, Hu Y, Tang J, Choi C, Lee M, Pang Y, Han Y. Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer. ACS Chem Neurosci. 2015 Sep 16; 6: (9)1536-45.
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30. Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Ma VP, Choi TC, Ma ED, Tao L, Pang Y, Rowan MJ, Anwyl R, Han Y, Wang Q. Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 2015 Jul 21; 5:10256 Epub 2015 July 21
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31. Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Tsim KW, Pang YP, Han YF. Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway. CNS Neurosci Ther. 2015 Jun; 21 (6):520-9 Epub 2015 Apr 28
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32. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. EBioMedicine. 2015 Apr 1; 2 (4):294-305
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33. Pang YP. At least 10% shorter C-H bonds in cryogenic protein crystal structures than in current AMBER forcefields. Biochem Biophys Res Commun. 2015 Mar 6; 458(2):352-5. Epub 2015 Feb 04.
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34. Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S. Plasma butyrylcholinesterase regulates ghrelin to control aggression. Proc Natl Acad Sci U S A. 2015 Feb 17; 112 (7):2251-6 Epub 2015 Feb 02
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35. Pang YP. Use of 1-4 interaction scaling factors to control the conformational equilibrium between alpha-helix and beta-strand. Biochem Biophys Res Commun. 2015 Feb 6; 457(2):183-6. Epub 2014 Dec 25.
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36. Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, Cummins NW, Correia C, Meng XW, Tarara JE, Ramirez-Alvarado M, Katzmann DJ, Ochsenbauer C, Kappes JC, Kaufmann SH, Badley AD. Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation. J Cell Biol. 2014 Sep 29; 206(7):867-76. Epub 2014 Sep 22.
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37. Pang YP. Low-mass molecular dynamics simulation: a simple and generic technique to enhance configurational sampling. Biochem Biophys Res Commun. 2014 Sep 26; 452(3):588-92. Epub 2014 Aug 30.
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38. Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014 Jan 3; 289(1):89-99. Epub 2013 Nov 21
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39. Pang YP. Insect acetylcholinesterase as a target for effective and environmentally safe insecticides. Advances in Insect Physiology. 2014; 46:435-94.
    
40. Yu S, Park JG, Kahn JN, Tumer NE, Pang YP. Common pharmacophore of structurally distinct small-molecule inhibitors of intracellular retrograde trafficking of ribosome inactivating proteins. Sci Rep. 2013 Dec 2; 3:3397 Epub 2013 Dec 02
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41. Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF. Substantial neuroprotection against K(+) deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway. CNS Neurosci Ther. 2013 Oct; 19(10):764-72. Epub 2013 Jul 04.
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42. Hu S, Cui W, Mak S, Tang J, Choi C, Pang Y, Han Y. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3beta pathways. Neurochem Int. 2013 Mar; 62(4):468-77. Epub 2013 Jan 26.
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43. Kim MS, Machida Y, Vashisht AA, Wohlschlegel JA, Pang YP, Machida YJ. Regulation of error-prone translesion synthesis by Spartan/C1orf124. Nucleic Acids Res. 2013 Feb 1; 41 (3):1661-8 Epub 2012 Dec 18
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44. Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP. Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases. Sci Rep. 2013; 3:1068 Epub 2013 Jan 15
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45. Yao L, Li W, She H, Dou J, Jia L, He Y, Yang Q, Zhu J, Capiro NL, Walker DI, Pennell KD, Pang Y, Liu Y, Han Y, Mao Z. Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. J Biol Chem. 2012 Oct 5; 287(41):34246-55. Epub 2012 Aug 13.
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46. Pang YP, Brimijoin S, Ragsdale DW, Brimijoin S, Zhu KY, Suranyi R. Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides. Curr Drug Targets. 2012 Apr; 13 (4):471-82
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47. Pang YP, Dai HM, Smith A, Meng XW, Schneider PA, Kaufmann SH. Bak conformational changes induced by ligand binding: insight into bh3 domain binding and bak homo-oligomerization. Scientific Reports. 2012 Feb 10; 2.
    
48. Park JG, Kahn JN, Tumer NE, Pang YP. Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins. Sci Rep. 2012; 2:631 Epub 2012 Sept 05
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49. Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY. Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum. Sci Rep. 2012; 2:288. Epub 2012 Feb 27.
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50. Lu Y, Pang YP, Park Y, Gao X, Yao J, Zhang X, Zhu KY. Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle. PLoS One. 2012; 7(2):e32288. Epub 2012 Feb 16.
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51. Dai H, Smith A, Meng XW, Schneider PA, Pang YP, Kaufmann SH. Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization. J Cell Biol. 2011 Jul 11; 194 (1):39-48 Epub 2011 July 04
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52. Pang YP, Park JG, Wang S, Vummenthala A, Mishra RK, McLaughlin JE, Di R, Kahn JN, Tumer NE, Janosi L, Davis J, Millard CB. Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach. PLoS One. 2011 Mar 24; 6 (3):e17883
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53. Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F. Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds. Biochem Pharmacol. 2010 Sep 15; 80(6):941-6. Epub 2010 May 26.
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54. Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S. Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle. Chem Biol Interact. 2010 Sep 6; 187 (1-3):142-7 Epub 2010 Jan 28
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55. Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. J Biol Chem. 2010 Jun 25; 285(26):19947-58. Epub 2010 Apr 19.
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56. Pang YP, Davis J, Wang S, Park JG, Nambiar MP, Schmidt JJ, Millard CB. Small molecules showing significant protection of mice against botulinum neurotoxin serotype A. PLoS One. 2010 Apr 13; 5 (4):e10129
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57. Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F. Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad. Biochem Pharmacol. 2010 Feb 1; 79(3):507-15. Epub 2009 Sep 02.
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58. Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. Eur J Pharmacol. 2009 Nov 25; 623(1-3):14-21. Epub 2009 Sep 16.
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59. Pang YP, Vummenthala A, Mishra RK, Park JG, Wang S, Davis J, Millard CB, Schmidt JJ. Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design. PLoS One. 2009 Nov 10; 4 (11):e7730
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60. Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S. Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases. PLoS One. 2009 Aug 28; 4 (8):e6851
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61. Yao K, Cho YY, Bode AM, Vummenthala A, Park JG, Liu K, Pang YP, Dong Z. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 2009 Jul 7; 583(13):2208-12. Epub 2009 Jun 13.
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62. Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY. Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. Neuropharmacology. 2009 Jul; 57(1):33-40. Epub 2009 Apr 22.
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63. Killian BJ, Kravitz JY, Somani S, Dasgupta P, Pang YP, Gilson MK. Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide. J Mol Biol. 2009 Jun 5; 389(2):315-35. Epub 2009 Apr 09.
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64. Tomlinson SM, Malmstrom RD, Russo A, Mueller N, Pang YP, Watowich SJ. Structure-based discovery of dengue virus protease inhibitors. Antiviral Res. 2009 Jun; 82(3):110-4. Epub 2009 Feb 21.
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65. Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP. Structure of HI-6-sarin-acetylcholinesterase determined by x-ray crystallography and molecular dynamics simulation: Reactivator mechanism and design. PLoS ONE. 2009; 4(6).
    
66. Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S. Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides. PLoS One. 2009; 4 (2):e4349 Epub 2009 Feb 04
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67. Zhao Y, Li W, Chow PC, Lau DT, Lee NT, Pang Y, Zhang X, Wang X, Han Y. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neurosci Lett. 2008 Jul 11; 439(2):160-4. Epub 2008 May 08.
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68. Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Gu ZM, Chan K, Wang YT, Zuo Z, Han YF. Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine. Int J Pharm. 2008 Jun 5; 357(1-2):85-94. Epub 2008 Feb 02.
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69. Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY. Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies. Neuropharmacology. 2008 Jun; 54(7):1086-94. Epub 2008 Mar 02.
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70. Liu YW, Li CY, Luo JL, Li WM, Fu HJ, Lao YZ, Liu LJ, Pang YP, Chang DC, Li ZW, Peoples RW, Ai YX, Han YF. Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochem Biophys Res Commun. 2008 May 16; 369(4):1007-11. Epub 2008 Mar 06.
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71. Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF. Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008 Apr; 22(4):414-20.
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72. Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochem Biophys Res Commun. 2008 Feb 15; 366(3):631-6. Epub 2007 Nov 26.
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73. Choi J, Park JG, Pang YP. Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin. Tetrahedron Lett. 2008 Feb 11; 49 (7):1103-1106
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74. Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. J Pharm Biomed Anal. 2008 Jan 7; 46(1):75-81. Epub 2007 Sep 04.
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75. Pang YP, Mullins TJ, Swartz BA, McAllister JS, Smith BE, Archer CJ, Musselman RG, Peters AE, Wallenfelt BP, Pinnow KW. EUDOC on the IBM Blue Gene/L system: Accelerating the transfer of drug discoveries from laboratory to patient. IBM Journal of Research & Development. 2008 Jan-Mar; 52(1-2):69-81.
    
76. Wang Q, Pang YP. Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations. PLoS One. 2007 Oct 10; 2 (10):e1025
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77. Luo J, Li W, Liu Y, Zhang W, Fu H, Lee NT, Yu H, Pang Y, Huang P, Xia J, Li ZW, Li CY, Han YF. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):505-9. Epub 2007 Jul 20.
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78. Wang Q, Pang YP. Preference of small molecules for local minimum conformations when binding to proteins. PLoS One. 2007 Sep 5; 2 (9):e820 Epub 2007 Sept 05
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79. Yu H, Ho JMK, Kan KKW, Cheng BWH, Li WM, Zhang L, Lin G, Pang YP, Gu ZM, Chan K, Wang YT, Han YF. Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood. J Pharm Biomed Anal. 2007 Sep 3; 44(5):1133-8.
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80. Ekstrom FJ, Astot C, Pang YP. Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes. Clin Pharmacol Ther. 2007 Sep; 82(3):282-93. Epub 2007 Apr 18.
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81. Li WM, Kan KK, Carlier PR, Pang YP, Han YF. East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Curr Alzheimer Res. 2007 Sep; 4(4):386-96.
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82. Tang J, Park JG, Millard CB, Schmidt JJ, Pang YP. Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A. PLoS One. 2007 Aug 22; 2 (8):e761
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83. Fu H, Li W, Liu Y, Lao Y, Liu W, Chen C, Yu H, Lee NT, Chang DC, Li P, Pang YP, Tsim KWK, Li MT, Han YF. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. J Proteome Res. 2007 Jul; 6(7):2435-46. Epub 2007 May 27.
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84. Wang Q, Pang YP. Accurate reproduction of 161 small-molecule complex crystal structures using the EUDOC program: expanding the use of EUDOC to supramolecular chemistry. PLoS One. 2007 Jun 13; 2 (6):e531 Epub 2007 June 13
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85. Li W, Xue J, Niu C, Fu H, Lam CS, Luo J, Chan HH, Xue H, Kan KK, Lee NT, Li C, Pang Y, Li M, Tsim KW, Jiang H, Chen K, Li X, Han YF. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Mol Pharmacol. 2007 May; 71(5):1258-67.
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87. Le SB, Hailer MK, Buhrow S, Wang Q, Flatten K, Pediaditakis P, Bible KC, Lewis LD, Sausville EA, Pang YP, Ames MM, Lemasters JJ, Holmuhamedov EL, Kaufmann SH. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem. 2007 Mar 23; 282(12):8860-72. Epub 2007 Jan 09.
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90. Pang YP. Species marker for developing novel and safe pesticides. Bioorg Med Chem Lett. 2007 Jan 1; 17(1):197-9. Epub 2006 Oct 12.
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102. Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase. J Am Chem Soc. 2005 Aug 10; 127(31):11029-36.
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108. Pang YP. Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences. Bioorg Med Chem. 2004 Jun 1; 12(11):3063-8.
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109. Park JG, Langenwalter KJ, Weinbaum CA, Casey PJ, Pang YP. Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. J Comb Chem. 2004 May-Jun; 6 (3):407-13
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125. Mangel WF, McGrath WJ, Brown MT, Baniecki ML, Barnard DL, Pang YP. A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it. Curr Med Chem. 2001 Jul; 8(8):933-9.
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136. Bible KC, Bible RH Jr, Kottke TJ, Svingen PA, Xu K, Pang YP, Hajdu E, Kaufmann SH. Flavopiridol binds to duplex DNA. Cancer Res. 2000 May 1; 60 (9):2419-28
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161. Pang YP, Silva ND, Haydock C, Prendergast FG. Docking studies on the complexed and uncomplexed FKBP12 structures with bound and unbound ligands - an implication of a conformational selection mechanism for binding. Journal of Molecular Modeling. 1997; 3(7):240-248.
     
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