Publications

  1. Vassilaki M, Syrjanen JA, Kremers WK, Hagen PT, Knopman DS, Mielke MM, Geda YE, Alhurani RE, Machulda MM, Roberts RO, Petersen RC. Medical Doctors and Dementia: A Longitudinal Study. J Am Geriatr Soc. 2020 Jun; 68 (6):1250-1255 Epub 2020 Feb 22
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  2. Vassilaki M, Aakre JA, Kremers WK, Lesnick TG, Mielke MM, Geda YE, Machulda MM, Knopman DS, Butler L, Traber M, Vemuri P, Lowe VJ, Jack CR Jr, Roberts RO, Petersen RC. Brain amyloid, cortical thickness, and changes in activities of daily living. Ann Clin Transl Neurol. 2020 Apr; 7 (4):474-485 Epub 2020 Apr 21
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  3. Vassilaki M, Aakre JA, Knopman DS, Kremers WK, Mielke MM, Geda YE, Machulda MM, Al Fakir R, Undavalli C, Roberts RO, Petersen RC. Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia. Age Ageing. 2019 Nov 1; 48 (6):888-894
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  4. Jack CR Jr, Therneau TM, Weigand SD, Wiste HJ, Knopman DS, Vemuri P, Lowe VJ, Mielke MM, Roberts RO, Machulda MM, Graff-Radford J, Jones DT, Schwarz CG, Gunter JL, Senjem ML, Rocca WA, Petersen RC. Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework. JAMA Neurol 2019 Oct 1; 76 (10):1174-1183
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  5. Stricker NH, Lundt ES, Edwards KK, Machulda MM, Kremers WK, Roberts RO, Knopman DS, Petersen RC, Mielke MM. Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: Assessing cross-modality equivalence of computerized neuropsychological tests. Clin Neuropsychol. 2019 Aug; 33(6):1102-1126. Epub 2018 Nov 10.
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  6. Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults. Neurology. 2019 Jul 2; 93 (1):e29-e39 Epub 2019 May 30
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  7. Jack CR Jr, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Lowe VJ, Vemuri P, Machulda MM, Schwarz CG, Gunter JL, Senjem ML, Graff-Radford J, Jones DT, Roberts RO, Rocca WA, Petersen RC. Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia. JAMA. 2019 Jun 18; 321 (23):2316-2325
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  8. Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Alhurani RE, Dutt T, Machulda MM, Knopman DS, Vemuri P, Coloma PM, Schauble B, Lowe VJ, Jack CR, Petersen RC, Roberts RO. The Association of Multimorbidity With Preclinical AD Stages and SNAP in Cognitively Unimpaired Persons. J Gerontol A Biol Sci Med Sci. 2019 May 16; 74 (6):877-883
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  9. Krell-Roesch J, Vassilaki M, Mielke MM, Kremers WK, Lowe VJ, Vemuri P, Machulda MM, Christianson TJ, Syrjanen JA, Stokin GB, Butler LM, Traber M, Jack CR Jr, Knopman DS, Roberts RO, Petersen RC, Geda YE. Cortical beta-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. Transl Psychiatry. 2019 Mar 28; 9 (1):123
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  10. Cerhan JH, Butts AM, Syrjanen JA, Aakre JA, Brown PD, Petersen RC, Jack CR Jr, Roberts RO. Factors Associated With Meningioma Detected in a Population-Based Sample. Mayo Clin Proc. 2019 Feb; 94 (2):254-261
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  11. Graff-Radford J, Botha H, Rabinstein AA, Gunter JL, Przybelski SA, Lesnick T, Huston J 3rd, Flemming KD, Preboske GM, Senjem ML, Brown RD Jr, Mielke MM, Roberts RO, Lowe VJ, Knopman DS, Petersen RC, Kremers W, Vemuri P, Jack CR Jr, Kantarci K. Cerebral microbleeds: Prevalence and relationship to amyloid burden. Neurology. 2019 Jan 15; 92 (3):e253-e262 Epub 2018 Dec 19
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  12. Zeydan B, Tosakulwong N, Schwarz CG, Senjem ML, Gunter JL, Reid RI, Gazzuola Rocca L, Lesnick TG, Smith CY, Bailey KR, Lowe VJ, Roberts RO, Jack CR Jr, Petersen RC, Miller VM, Mielke MM, Rocca WA, Kantarci K. Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration. JAMA Neurol. 2019 Jan 1; 76 (1):95-100
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  13. Petersen RC, Lundt ES, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Roberts RO, Lowe VJ, Machulda MM, Kremers WK, Geda YE, Jack CR Jr. Predicting Progression to Mild Cognitive Impairment. Ann Neurol. 2019 Jan; 85 (1):155-160 Epub 2019 Jan 07
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  14. Krell-Roesch J, Cerhan LP, Machulda MM, Roberts RO, Mielke MM, Knopman DS, Syrjanen JA, Christianson TJ, Petersen RC, Geda YE. Functional Activity and Neuropsychiatric Symptoms in Normal Aging and Mild Cognitive Impairment: The Mayo Clinic Study of Aging. Alzheimer Dis Assoc Disord. 2019 Jan-Mar; 33 (1):68-71
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  15. Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Machulda MM, Knopman DS, Coloma PM, Schauble B, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC, Roberts RO. Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia. J Am Geriatr Soc. 2018 Dec; 66 (12):2274-2281 Epub 2018 Nov 21
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  16. Schulte PJ, Martin DP, Deljou A, Sabov M, Roberts RO, Knopman DS, Petersen RC, Weingarten TN, Hanson AC, Schroeder DR, Warner DO, Sprung J. Effect of Cognitive Status on the Receipt of Procedures Requiring Anesthesia and Critical Care Admissions in Older Adults. Mayo Clin Proc. 2018 Nov; 93 (11):1552-1562 Epub 2018 Sept 28
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  17. Zhan Y, Clements MS, Roberts RO, Vassilaki M, Druliner BR, Boardman LA, Petersen RC, Reynolds CA, Pedersen NL, Hagg S. Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies. Neurobiol Aging. 2018 Sep; 69:111-116 Epub 2018 June 02
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  18. Wennberg AMV, Lesnick TG, Schwarz CG, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, Vemuri P, Jack CR Jr, Petersen RC, Mielke MM. Longitudinal Association Between Brain Amyloid-Beta and Gait in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2018 Aug 10; 73 (9):1244-1250
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  19. Schulte PJ, Roberts RO, Knopman DS, Petersen RC, Hanson AC, Schroeder DR, Weingarten TN, Martin DP, Warner DO, Sprung J. Association between exposure to anaesthesia and surgery and long-term cognitive trajectories in older adults: report from the Mayo Clinic Study of Aging. Br J Anaesth. 2018 Aug; 121 (2):398-405 Epub 2018 June 27
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  20. Wennberg AMV, Hagen CE, Edwards K, Roberts RO, Machulda MM, Knopman DS, Petersen RC, Mielke MM. Association of antidiabetic medication use, cognitive decline, and risk of cognitive impairment in older people with type 2 diabetes: Results from the population-based Mayo Clinic Study of Aging. Int J Geriatr Psychiatry. 2018 Aug; 33 (8):1114-1120 Epub 2018 June 05
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  21. Roberts RO, Aakre JA, Kremers WK, Vassilaki M, Knopman DS, Mielke MM, Alhurani R, Geda YE, Machulda MM, Coloma P, Schauble B, Lowe VJ, Jack CR Jr, Petersen RC. Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting. JAMA Neurol. 2018 Aug 1; 75 (8):970-979
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  22. Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL. Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography. Alzheimers Dement. 2018 Aug; 14 (8):989-997 Epub 2018 Apr 05
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  23. van Harten AC, Mielke MM, Swenson-Dravis DM, Hagen CE, Edwards KK, Roberts RO, Geda YE, Knopman DS, Petersen RC. Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging. Neurology. 2018 Jul 24; 91 (4):e300-e312 Epub 2018 June 29
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  24. Wennberg AMV, Hagen CE, Machulda MM, Hollman JH, Roberts RO, Knopman DS, Petersen RC, Mielke MM. The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging. Neurobiol Aging. 2018 Jun; 66:68-74 Epub 2018 Feb 19
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  25. Carvalho DZ, St Louis EK, Knopman DS, Boeve BF, Lowe VJ, Roberts RO, Mielke MM, Przybelski SA, Machulda MM, Petersen RC, Jack CR Jr, Vemuri P. Association of Excessive Daytime Sleepiness With Longitudinal beta-Amyloid Accumulation in Elderly Persons Without Dementia. JAMA Neurol. 2018 Jun 1; 75 (6):672-680
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  26. Jack CR Jr, Wiste HJ, Schwarz CG, Lowe VJ, Senjem ML, Vemuri P, Weigand SD, Therneau TM, Knopman DS, Gunter JL, Jones DT, Graff-Radford J, Kantarci K, Roberts RO, Mielke MM, Machulda MM, Petersen RC. Longitudinal tau PET in ageing and Alzheimer's disease. Brain. 2018 May 1; 141 (5):1517-1528
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  27. Zeydan B, Lowe VJ, Schwarz CG, Przybelski SA, Tosakulwong N, Zuk SM, Senjem ML, Gunter JL, Roberts RO, Mielke MM, Benarroch EE, Rodriguez M, Machulda MM, Lesnick TG, Knopman DS, Petersen RC, Jack CR Jr, Kantarci K, Kantarci OH. Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis. Mult Scler. 2018 May; 24 (6):739-749 Epub 2017 May 05
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  28. Knopman DS, Lundt ES, Therneau TM, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC, Jack CR Jr. Joint associations of beta-amyloidosis and cortical thickness with cognition. Neurobiol Aging. 2018 May; 65:121-131 Epub 2018 Feb 02
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  29. Fatemi F, Kantarci K, Graff-Radford J, Preboske GM, Weigand SD, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Mielke MM, Petersen RC, Jack CR Jr, Vemuri P. Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly. Neurology. 2018 Feb 6; 90 (6):e466-e473 Epub 2018 Jan 17
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  30. Krell-Roesch J, Lowe VJ, Neureiter J, Pink A, Roberts RO, Mielke MM, Vemuri P, Stokin GB, Christianson TJ, Jack CR, Knopman DS, Boeve BF, Kremers WK, Petersen RC, Geda YE. Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging. Int Psychogeriatr. 2018 Feb; 30 (2):245-251 Epub 2017 Dec 04
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  31. Ramanan VK, Przybelski SA, Graff-Radford J, Castillo AM, Lowe VJ, Mielke MM, Roberts RO, Reid RI, Knopman DS, Jack CR, Petersen RC, Vemuri P. Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. J Alzheimers Dis. 2018; 65 (4):1345-1352
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  32. Krell-Roesch J, Feder NT, Roberts RO, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Geda YE. Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2018; 63 (1):149-155
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  33. Vassilaki M, Aakre JA, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Alhurani RE, Staubo SC, Knopman DS, Petersen RC, Lowe VJ, Jack CR, Roberts RO. Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis. 2018; 64 (1):281-290
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  34. Lowe VJ, Wiste HJ, Senjem ML, Weigand SD, Therneau TM, Boeve BF, Josephs KA, Fang P, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. Brain. 2018 Jan 1; 141 (1):271-287
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  35. Pink A, Przybelski SA, Krell-Roesch J, Stokin GB, Roberts RO, Mielke MM, Spangehl KA, Knopman DS, Jack CR Jr, Petersen RC, Geda YE. Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Neuropsychiatry Clin Neurosci. 2017 Winter; 29 (1):60-66 Epub 2016 Aug 31
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  36. Roberts RO, Knopman DS, Syrjanen JA, Aakre JA, Vassilaki M, Kremers WK, Mielke MM, Machulda MM, Graff-Radford J, Geda YE, Vemuri P, Lowe V, Jack CR Jr, Petersen RC. Weighting and standardization of frequencies to determine prevalence of AD imaging biomarkers. Neurology. 2017 Nov 14; 89 (20):2039-2048 Epub 2017 Oct 13
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  37. Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Lowe VJ, Graff-Radford J, Roberts RO, Mielke MM, Machulda MM, Petersen RC, Jack CR Jr. Age, vascular health, and Alzheimer disease biomarkers in an elderly sample. Ann Neurol. 2017 Nov; 82 (5):706-718 Epub 2017 Oct 26
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  38. Emerson JA, Smith CY, Long KH, Ransom JE, Roberts RO, Hass SL, Duhig AM, Petersen RC, Leibson CL. Nursing Home Use Across The Spectrum of Cognitive Decline: Merging Mayo Clinic Study of Aging With CMS MDS Assessments. J Am Geriatr Soc. 2017 Oct; 65 (10):2235-2243 Epub 2017 Sept 11
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  39. Nedelska Z, Przybelski SA, Lesnick TG, Schwarz CG, Lowe VJ, Machulda MM, Kremers WK, Mielke MM, Roberts RO, Boeve BF, Knopman DS, Petersen RC, Jack CR Jr, Kantarci K. (1)H-MRS metabolites and rate of beta-amyloid accumulation on serial PET in clinically normal adults. Neurology. 2017 Sep 26; 89 (13):1391-1399 Epub 2017 Aug 25
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  40. Mielke MM, Hagen CE, Wennberg AMV, Airey DC, Savica R, Knopman DS, Machulda MM, Roberts RO, Jack CR Jr, Petersen RC, Dage JL. Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging. JAMA Neurol. 2017 Sep 1; 74 (9):1073-1080
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  41. Sprung J, Roberts RO, Weingarten TN, Nunes Cavalcante A, Knopman DS, Petersen RC, Hanson AC, Schroeder DR, Warner DO. Postoperative delirium in elderly patients is associated with subsequent cognitive impairment. Br J Anaesth. 2017 Aug 1; 119 (2):316-323
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  42. Flemming KD, Graff-Radford J, Aakre J, Kantarci K, Lanzino G, Brown RD Jr, Mielke MM, Roberts RO, Kremers W, Knopman DS, Petersen RC, Jack CR Jr. Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults: Mayo Clinic Study of Aging. JAMA Neurol. 2017 Jul 1; 74 (7):801-805
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  43. Vassilaki M, Christianson TJ, Mielke MM, Geda YE, Kremers WK, Machulda MM, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Roberts RO. Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals. Ann Neurol. 2017 Jun; 81 (6):871-882 Epub 2017 June 09
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  44. Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Knopman DS, Lowe V, Vemuri P, Mielke MM, Roberts RO, Machulda MM, Senjem ML, Gunter JL, Rocca WA, Petersen RC. Age-specific and sex-specific prevalence of cerebral beta-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study. Lancet Neurol. 2017 Jun; 16 (6):435-444 Epub 2017 Apr 26
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  45. Vemuri P, Knopman DS, Lesnick TG, Przybelski SA, Mielke MM, Graff-Radford J, Murray ME, Roberts RO, Vassilaki M, Lowe VJ, Machulda MM, Jones DT, Petersen RC, Jack CR Jr. Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals. JAMA Neurol. 2017 Jun 1; 74 (6):718-726
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  46. Wennberg AMV, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, Vemuri P, Jack CR Jr, Petersen RC, Mielke MM. Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging. J Am Geriatr Soc. 2017 Apr; 65 (4):792-799 Epub 2016 Nov 21
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  47. Carvalho DZ, St Louis EK, Boeve BF, Mielke MM, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Geda YE, Petersen RC, Jack CR Jr, Vemuri P. Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults. Sleep Med. 2017 Apr; 32:236-243 Epub 2016 Nov 03
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  48. Sprung J, Roberts RO, Knopman DS, Price LL, Schulz HP, Tatsuyama CL, Weingarten TN, Schroeder DR, Hanson AC, Petersen RC, Warner DO. Mild Cognitive Impairment and Exposure to General Anesthesia for Surgeries and Procedures: A Population-Based Case-Control Study. Anesth Analg. 2017 Apr; 124 (4):1277-1290
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  49. Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC. Defining imaging biomarker cut points for brain aging and Alzheimer's disease. Alzheimers Dement. 2017 Mar; 13 (3):205-216 Epub 2016 Sept 30
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  50. Krell-Roesch J, Vemuri P, Pink A, Roberts RO, Stokin GB, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Kremers WK, Geda YE. Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE epsilon4 Genotype. JAMA Neurol. 2017 Mar 1; 74 (3):332-338
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  51. Staubo SC, Aakre JA, Vemuri P, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Knopman DS, Petersen RC, Jack CR Jr, Roberts RO. Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness. Alzheimers Dement. 2017 Feb; 13(2):168-177. Epub 2016 Jul 25.
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  52. Amra S, O'Horo JC, Singh TD, Wilson GA, Kashyap R, Petersen R, Roberts RO, Fryer JD, Rabinstein AA, Gajic O. Derivation and validation of the automated search algorithms to identify cognitive impairment and dementia in electronic health records. J Crit Care. 2017 Feb; 37:202-205 Epub 2016 Oct 08
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  53. Machulda MM, Hagen CE, Wiste HJ, Mielke MM, Knopman DS, Roberts RO, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC. [Formula: see text]Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status. Clin Neuropsychol. 2017 Jan; 31 (1):99-117 Epub 2016 Oct 11
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  54. Savica R, Wennberg AM, Hagen C, Edwards K, Roberts RO, Hollman JH, Knopman DS, Boeve BF, Machulda MM, Petersen RC, Mielke MM. Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2017; 55(2):559-567.
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  55. Roberts RO, Kang YN, Hu C, Moser CD, Wang S, Moore MJ, Graham RP, Lai JP, Petersen RC, Roberts LR. Decreased Expression of Sulfatase 2 in the Brains of Alzheimer's Disease Patients: Implications for Regulation of Neuronal Cell Signaling. J Alzheimers Dis Rep. 2017; 1 (1):115-124 Epub 2017 Sept 28
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  56. Pink A, Przybelski SA, Krell-Roesch J, Stokin GB, Roberts RO, Mielke MM, Knopman DS, Jack CR, Petersen RC, Geda YE. Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2017; 58 (4):1273-1281
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  57. Krell-Roesch J, Pink A, Roberts RO, Stokin GB, Mielke MM, Spangehl KA, Bartley MM, Knopman DS, Christianson TJ, Petersen RC, Geda YE. Timing of Physical Activity, Apolipoprotein E epsilon4 Genotype, and Risk of Incident Mild Cognitive Impairment. J Am Geriatr Soc. 2016 Dec; 64 (12):2479-2486 Epub 2016 Nov 01
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  58. Dage JL, Wennberg AMV, Airey DC, Hagen CE, Knopman DS, Machulda MM, Roberts RO, Jack CR Jr, Petersen RC, Mielke MM. Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort. Alzheimers Dement. 2016 Dec; 12 (12):1226-1234 Epub 2016 July 18
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  59. Knopman DS, Jack CR Jr, Lundt ES, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum. Neurobiol Aging. 2016 Oct; 46:32-42 Epub 2016 June 16
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  60. Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia. Neurology. 2016 Aug 16; 87 (7):691-8 Epub 2016 July 15
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  61. Krell-Roesch J, Ruider H, Lowe VJ, Stokin GB, Pink A, Roberts RO, Mielke MM, Knopman DS, Christianson TJ, Machulda MM, Jack CR, Petersen RC, Geda YE. FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2016 Jul 14; 53 (4):1609-16
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  62. Vassilaki M, Aakre JA, Mielke MM, Geda YE, Kremers WK, Alhurani RE, Machulda MM, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Roberts RO. Multimorbidity and neuroimaging biomarkers among cognitively normal persons. Neurology. 2016 May 31; 86 (22):2077-84 Epub 2016 Apr 13
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  63. Wennberg AM, Gustafson D, Hagen CE, Roberts RO, Knopman D, Jack C, Petersen RC, Mielke MM. Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging. J Alzheimers Dis. 2016 May 4; 53 (2):573-81
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  64. Alhurani RE, Vassilaki M, Aakre JA, Mielke MM, Kremers WK, Machulda MM, Geda YE, Knopman DS, Petersen RC, Roberts RO. Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging. JAMA Neurol. 2016 Apr; 73 (4):439-46
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  65. Graff-Radford J, Madhavan M, Vemuri P, Rabinstein AA, Cha RH, Mielke MM, Kantarci K, Lowe V, Senjem ML, Gunter JL, Knopman DS, Petersen RC, Jack CR Jr, Roberts RO. Atrial fibrillation, cognitive impairment, and neuroimaging. Alzheimers Dement. 2016 Apr; 12 (4):391-8 Epub 2015 Oct 23
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  66. Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Machulda M, Lowe VJ, Mielke MM, Roberts RO, Gunter JL, Senjem ML, Geda YE, Rocca WA, Petersen RC, Jack CR Jr. Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study. Neurology. 2016 Mar 22; 86 (12):1128-35 Epub 2016 Feb 24
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  67. Mielke MM, Machulda MM, Hagen CE, Christianson TJ, Roberts RO, Knopman DS, Vemuri P, Lowe VJ, Kremers WK, Jack CR Jr, Petersen RC. Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort. Alzheimers Dement. 2016 Mar; 12 (3):281-91 Epub 2015 Nov 19
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  68. Sprung J, Roberts RO, Knopman DS, Olive DM, Gappa JL, Sifuentes VL, Behrend TL, Farmer JD, Weingarten TN, Hanson AC, Schroeder DR, Petersen RC, Warner DO. Association of Mild Cognitive Impairment With Exposure to General Anesthesia for Surgical and Nonsurgical Procedures: A Population-Based Study. Mayo Clin Proc. 2016 Feb; 91 (2):208-17 Epub 2016 Jan 20
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  69. Petersen RC, Wiste HJ, Weigand SD, Rocca WA, Roberts RO, Mielke MM, Lowe VJ, Knopman DS, Pankratz VS, Machulda MM, Geda YE, Jack CR Jr. Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community. JAMA Neurol. 2016 Jan; 73 (1):85-92
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  70. Jack CR Jr, Therneau TM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Mielke MM, Vemuri P, Roberts RO, Machulda MM, Senjem ML, Gunter JL, Rocca WA, Petersen RC. Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study. Lancet Neurol. 2016 Jan; 15 (1):56-64 Epub 2015 Nov 18
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  71. Bartley MM, Geda YE, Christianson TJ, Pankratz VS, Roberts RO, Petersen RC. Frailty and Mortality Outcomes in Cognitively Normal Older People: Sex Differences in a Population-Based Study. J Am Geriatr Soc. 2016 Jan; 64 (1):132-7
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  72. Roberts RO, Christianson TJ, Kremers WK, Mielke MM, Machulda MM, Vassilaki M, Alhurani RE, Geda YE, Knopman DS, Petersen RC. Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia. JAMA Neurol. 2016 Jan; 73 (1):93-101
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  73. Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Mielke MM, Vemuri P, Lowe V, Senjem ML, Gunter JL, Reyes D, Machulda MM, Roberts R, Petersen RC. Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings. Brain. 2015 Dec; 138 (Pt 12):3747-59 Epub 2015 Sept 30
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  74. Knopman DS, Jack CR Jr, Lundt ES, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Role of beta-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment. JAMA Neurol. 2015 Dec; 72 (12):1475-83
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  75. Knopman DS, Beiser A, Machulda MM, Fields J, Roberts RO, Pankratz VS, Aakre J, Cha RH, Rocca WA, Mielke MM, Boeve BF, Devine S, Ivnik RJ, Au R, Auerbach S, Wolf PA, Seshadri S, Petersen RC. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 2015 Nov 10; 85 (19):1712-21 Epub 2015 Oct 09
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  87. Zhang X, Harmsen WS, Mettler TA, Kim WR, Roberts RO, Therneau TM, Roberts LR, Chaiteerakij R. Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology. 2014 Dec; 60 (6):2008-16 Epub 2014 July 31
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  92. Nicholson AM, Finch NA, Thomas CS, Wojtas A, Rutherford NJ, Mielke MM, Roberts RO, Boeve BF, Knopman DS, Petersen RC, Rademakers R. Progranulin protein levels are differently regulated in plasma and CSF. Neurology. 2014 May 27; 82 (21):1871-8 Epub 2014 Apr 25
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  115. Chaiteerakij R, Yang JD, Harmsen WS, Slettedahl SW, Mettler TA, Fredericksen ZS, Kim WR, Gores GJ, Roberts RO, Olson JE, Therneau TM, Roberts LR. Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced cancer risk. Hepatology. 2013 Feb; 57 (2):648-55 Epub 2012 Dec 12
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  116. Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cosmic. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013; 13:165. Epub 2013 Nov 06.
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  129. Shire AM, Sandhu DS, Kaiya JK, Oseini AM, Yang JD, Chaiteerakij R, Mettler TA, Giama NH, Roberts RO, Therneau TM, Petersen GM, Knutson KL, Roberts LR. Viral hepatitis among Somali immigrants in Minnesota: association of hepatitis C with hepatocellular carcinoma. Mayo Clin Proc. 2012 Jan; 87 (1):17-24
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  130. Knopman DS, Roberts RO. Estimating the number of persons with frontotemporal lobar degeneration in the US population. J Mol Neurosci. 2011 Nov; 45 (3):330-5 Epub 2011 May 17
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  132. Negash S, Smith GE, Pankratz S, Aakre J, Geda YE, Roberts RO, Knopman DS, Boeve BF, Ivnik RJ, Petersen RC. Successful aging: definitions and prediction of longevity and conversion to mild cognitive impairment. Am J Geriatr Psychiatry. 2011 Jun; 19 (6):581-8
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  133. Geda YE, Topazian HM, Roberts LA, Roberts RO, Knopman DS, Pankratz VS, Christianson TJ, Boeve BF, Tangalos EG, Ivnik RJ, Petersen RC. Engaging in cognitive activities, aging, and mild cognitive impairment: a population-based study. J Neuropsychiatry Clin Neurosci. 2011 Spring; 23 (2):149-54
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  135. Shi Y, Hooten WM, Roberts RO, Warner DO. Modifiable risk factors for incidence of pain in older adults. Pain. 2010 Nov; 151 (2):366-371 Epub 2010 Aug 08
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  150. Bergstralh EJ, Roberts RO, Farmer SA, Slezak JM, Lieber MM, Jacobsen SJ. Population-based case-control study of PSA and DRE screening on prostate cancer mortality. Urology. 2007 Nov; 70 (5):936-41
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  151. Burke JP, Jacobson DJ, McGree ME, Nehra A, Roberts RO, Girman CJ, Lieber MM, Jacobsen SJ. Diabetes and sexual dysfunction: results from the Olmsted County study of urinary symptoms and health status among men. J Urol. 2007 Apr; 177 (4):1438-42
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  152. Leerapun A, Suravarapu SV, Bida JP, Clark RJ, Sanders EL, Mettler TA, Stadheim LM, Aderca I, Moser CD, Nagorney DM, LaRusso NF, de Groen PC, Menon KV, Lazaridis KN, Gores GJ, Charlton MR, Roberts RO, Therneau TM, Katzmann JA, Roberts LR. The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population. Clin Gastroenterol Hepatol. 2007 Mar; 5 (3):394-402; quiz 267
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  154. Gades NM, Jacobson DJ, McGree ME, Lieber MM, Roberts RO, Girman CJ, Jacobsen SJ. Dropout in a longitudinal, cohort study of urologic disease in community men. BMC Med Res Methodol. 2006 Dec 14; 6:58.
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  156. Suravarapu S, Bergstralh EJ, Farmer SA, Knopman DS, Jacobsen SJ, Roberts RO. Dementia and low testosterone and bioavailable testosterone levels in men: possible increased risk. Alzheimer Dis Assoc Disord. 2006 Jul-Sep; 20 (3):138-40
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  157. Roberts RO, Cha RH, Knopman DS, Petersen RC, Rocca WA. Postmenopausal estrogen therapy and Alzheimer disease: overall negative findings. Alzheimer Dis Assoc Disord. 2006 Jul-Sep; 20 (3):141-6
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  158. Burke JP, Rhodes T, Jacobson DJ, McGree ME, Roberts RO, Girman CJ, Lieber MM, Jacobsen SJ. Association of anthropometric measures with the presence and progression of benign prostatic hyperplasia. Am J Epidemiol. 2006 Jul 01; 164(1):41-6. Epub 2006 Apr 12.
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  159. Roberts RO, Bergstralh EJ, Farmer SA, Jacobson DJ, Hebbring SJ, Cunningham JM, Thibodeau SN, Lieber MM, Jacobsen SJ. Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia. Prostate. 2006 Mar 1; 66 (4):392-404
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  179. Roberts RO, Bergstralh EJ, Bass SE, Lightner DJ, Lieber MM, Jacobsen SJ. Incidence of physician-diagnosed interstitial cystitis in Olmsted County: a community-based study. BJU Int. 2003 Feb; 91 (3):181-5
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  192. Xia Z, Roberts RO, Schottenfeld D, Lieber MM, Jacobsen SJ. Trends in prostatectomy for benign prostatic hyperplasia among black and white men in the United States: 1980 to 1994. Urology. 1999 Jun; 53 (6):1154-9
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  194. Girman CJ, Jacobsen SJ, Rhodes T, Guess HA, Roberts RO, Lieber MM. Association of health-related quality of life and benign prostatic enlargement. Eur Urol. 1999 Apr; 35(4):277-84.
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