Publications

1. Schanche T, Han YS, Jensen CW, Arteaga GM, Tveita T, Sieck GC. beta-adrenergic stimulation after rewarming does not mitigate hypothermia-induced contractile dysfunction in rat cardiomyocytes. Cryobiology. 2024 Sep; 116:104927 Epub 2024 June 25
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2. Han YS, Pakkam M, Fogarty MJ, Sieck GC, Brozovich FV. Alterations in cardiac contractile and regulatory proteins contribute to age-related cardiac dysfunction in male rats. Physiol Rep. 2024 Aug; 12 (16):e70012
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3. Han YS, Bandi R, Fogarty MJ, Sieck GC, Brozovich FV. Aging related decreases in NM myosin expression and contractility in a resistance vessel. Front Physiol. 2024; 15:1411420 Epub 2024 May 14
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4. Cho JS, Han YS, Jensen C, Sieck G. Effects of arginase inhibition on myocardial Ca(2+) and contractile responses. Physiol Rep. 2022 Jul; 10 (14):e15396
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5. Jensen CW, Han YS, Sieck GC. Inhibiting Actin Polymerization Increases Tension Cost in Porcine Airway Smooth Muscle. FASEB J. 2022 May; 36 Suppl 1
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6. Brozovich FV, Han YS, Arteaga GM, Sharain K, Sieck GC. Changes in Cardiac and Vascular Contractile Protein in a Rat Model of Heart Failure with Preserved Ejection Fraction. FASEB J. 2022 May; 36 Suppl 1
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7. Davis LA, Forero L, Hernandez-Vizcarrondo G, Han YS, Mantilla CB, Sieck GC. Force and Shortening Velocity are Reduced in 24-month Fischer 344 Rats. FASEB J. 2022 May; 36 Suppl 1
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8. Han YS, Delmotte PF, Arteaga GM, Sieck GC. Dynamic cytosolic Ca(2+) and force responses to muscarinic stimulation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1; 321 (1):L91-L101 Epub 2021 Apr 28
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9. Han YS, Delmotte P, Sieck GC. Effects of TNFalpha on Dynamic Cytosolic Ca(2 +) and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle. Front Physiol. 2021; 12:730333 Epub 2021 July 30
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10. Delmotte P, Han YS, Sieck GC. Cytoskeletal remodeling slows cross-bridge cycling and ATP hydrolysis rates in airway smooth muscle. Physiol Rep. 2020 Aug; 8 (16):e14561
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11. Lyle MA, Alabdaljabar MS, Han YS, Brozovich FV. The vasculature in HFpEF vs HFrEF: differences in contractile protein expression produce distinct phenotypes. Heliyon. 2020 Jan; 6 (1):e03129 Epub 2019 Dec 30
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12. Tveita T, Arteaga GM, Han YS, Sieck GC. Cardiac troponin-I phosphorylation underlies myocardial contractile dysfunction induced by hypothermia rewarming. Am J Physiol Heart Circ Physiol. 2019 Oct 1; 317 (4):H726-H731 Epub 2019 Aug 02
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13. Sieck GC, Dogan M, Young-Soo H, Osorio Valencia S, Delmotte P. Mechanisms underlying TNFalpha-induced enhancement of force generation in airway smooth muscle. Physiol Rep. 2019 Sep; 7 (17):e14220
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14. Li EA, Xi W, Han YS, Brozovich FV. Phosphodiesterase expression in the normal and failing heart. Arch Biochem Biophys. 2019 Feb 15; 662:160-168 Epub 2018 Dec 11
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15. Han YS, Schaible N, Tveita T, Sieck G. Discontinued stimulation of cardiomyocytes provides protection against hypothermia-rewarming-induced disruption of excitation-contraction coupling. Exp Physiol. 2018 Jun; 103 (6):819-826 Epub 2018 May 05
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16. Schaible N, Han YS, Tveita T, Sieck GC. Role of superoxide ion formation in hypothermia/rewarming induced contractile dysfunction in cardiomyocytes. Cryobiology. 2018 Apr; 81:57-64 Epub 2018 Feb 16
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17. Dogan M, Han YS, Delmotte P, Sieck GC. TNFalpha enhances force generation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1; 312 (6):L994-L1002 Epub 2017 Apr 06
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18. Schaible N, Han YS, Hoang T, Arteaga G, Tveita T, Sieck G. Hypothermia/rewarming disrupts excitation-contraction coupling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2016 Jun 1; 310 (11):H1533-40 Epub 2016 Mar 18
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19. Han YS, Kavoussi SC, Adelman RA. Visual recovery following open globe injury with initial no light perception. Clin Ophthalmol. 2015; 9:1443-8 Epub 2015 Aug 11
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20. Hu YC, Yan LF, Wu L, Du P, Chen BY, Wang L, Wang SM, Han Y, Tian Q, Yu Y, Xu TY, Wang W, Cui GB. Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: efficacy in preoperative grading. Sci Rep. 2014 Dec 1; 4:7208 Epub 2014 Dec 01
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21. Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO, Rand K, Wan P, Stram A, Sheng X, Pooler LC, Park K, Xia L, Tyrer J, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Goh C, Ahmed M, Govindasami K, Guy M, Tammela TL, Auvinen A, Wahlfors T, Schleutker J, Visakorpi T, Leinonen KA, Xu J, Aly M, Donovan J, Travis RC, Key TJ, Siddiq A, Canzian F, Khaw KT, Takahashi A, Kubo M, Pharoah P, Pashayan N, Weischer M, Nordestgaard BG, Nielsen SF, Klarskov P, Roder MA, Iversen P, Thibodeau SN, McDonnell SK, Schaid DJ, Stanford JL, Kolb S, Holt S, Knudsen B, Coll AH, Gapstur SM, Diver WR, Stevens VL, Maier C, Luedeke M, Herkommer K, Rinckleb AE, Strom SS, Pettaway C, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, Cannon-Albright L, Cybulski C, Wokolorczyk D, Kluzniak W, Park J, Sellers T, Lin HY, Isaacs WB, Partin AW, Brenner H, Dieffenbach AK, Stegmaier C, Chen C, Giovannucci EL, Ma J, Stampfer M, Penney KL, Mucci L, John EM, Ingles SA, Kittles RA, Murphy AB, Pandha H, Michael A, Kierzek AM, Blot W, Signorello LB, Zheng W, Albanes D, Virtamo J, Weinstein S, Nemesure B, Carpten J, Leske C, Wu SY, Hennis A, Kibel AS, Rybicki BA, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Batra J, Clements J, Spurdle A, Teixeira MR, Paulo P, Maia S, Slavov C, Kaneva R, Mitev V, Witte JS, Casey G, Gillanders EM, Seminara D, Riboli E, Hamdy FC, Coetzee GA, Li Q, Freedman ML, Hunter DJ, Muir K, Gronberg H, Neal DE, Southey M, Giles GG, Severi G, Cook MB, Nakagawa H, Wiklund F, Kraft P, Chanock SJ, Henderson BE, Easton DF, Eeles RA, Haiman CA, Breast and Prostate Cancer Cohort Consortium (BPC3)//PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium//COGS (Collaborative Oncological Gene-environment Study) Consortium//GAME-ON/ELLIPSE Consortium. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014 Oct; 46 (10):1103-9 Epub 2014 Sept 14
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22. Konik EA, Han YS, Brozovich FV. The role of pulmonary vascular contractile protein expression in pulmonary arterial hypertension. J Mol Cell Cardiol. 2013 Dec; 65:147-55. Epub 2013 Oct 23.
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23. Han YS, Arroyo J, Ogut O. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. Arch Biochem Biophys. 2013 Oct 1; 538 (1):25-33 Epub 2013 Aug 11
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24. Han YS, Brozovich FV. Altered reactivity of tertiary mesenteric arteries following acute myocardial ischemia. J Vasc Res. 2013; 50 (2):100-8 Epub 2012 Nov 21
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25. Han YS, Ogut O. Force relaxation and thin filament protein phosphorylation during acute myocardial ischemia. Cytoskeleton (Hoboken). 2011 Jan; 68 (1):18-31 Epub 2010 Nov 02
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26. Han YS, Ogut O. Regulation of fibre contraction in a rat model of myocardial ischemia. PLoS One. 2010 Mar 4; 5 (3):e9528 Epub 2010 Mar 04
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27. Han YS, Tveita T, Prakash YS, Sieck GC. Mechanisms underlying hypothermia-induced cardiac contractile dysfunction. Am J Physiol Heart Circ Physiol. 2010 Mar; 298 (3):H890-7 Epub 2009 Dec 18
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28. Han YS, Tveita T, Kondratiev TV, Prakash YS, Sieck GC. Changes in cardiovascular beta-adrenoceptor responses during hypothermia. Cryobiology. 2008 Dec; 57(3):246-50. Epub 2008 Sep 19.
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29. Zhao Y, Li W, Chow PC, Lau DT, Lee NT, Pang Y, Zhang X, Wang X, Han Y. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neurosci Lett. 2008 Jul 11; 439(2):160-4. Epub 2008 May 08.
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30. Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochem Biophys Res Commun. 2008 Feb 15; 366(3):631-6. Epub 2007 Nov 26.
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31. Sieck GC, Zhan WZ, Han YS, Prakash YS. Effect of denervation on ATP consumption rate of diaphragm muscle fibers. J Appl Physiol (1985). 2007 Sep; 103(3):858-66. Epub 2007 Jun 07.
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32. Qian Q, Hunter LW, Du H, Ren Q, Han Y, Sieck GC. Pkd2+/- vascular smooth muscles develop exaggerated vasocontraction in response to phenylephrine stimulation. J Am Soc Nephrol. 2007 Feb; 18: (2)485-93.
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33. Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KW, Pang Y, Li Z, Chang DC, Li M, Han Y. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J Neurochem. 2006 Sep; 98(5):1400-10. Epub 2006 Jun 12.
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34. Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KW, Li X, Han Y. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 2006 Apr 3; 17(5):471-4.
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35. Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, Feitoza S, Sieck G, Chini EN. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology. 2004 Feb; 145 (2):881-9 Epub 2003 Oct 16
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36. Han YS, Geiger PC, Cody MJ, Macken RL, Sieck GC. ATP consumption rate per cross bridge depends on myosin heavy chain isoform. J Appl Physiol (1985). 2003 Jun; 94(6):2188-96. Epub 2003 Feb 14.
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37. Sieck GC, Prakash YS, Han YS, Fang YH, Geiger PC, Zhan WZ. Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development. J Appl Physiol (1985). 2003 May; 94(5):1896-902. Epub 2003 Jan 31.
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38. Geiger PC, Cody MJ, Han YS, Hunter LW, Zhan WZ, Sieck GC. Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers. J Appl Physiol (1985). 2002 Apr; 92: (4)1506-14.
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39. Sieck GC, Han YS, Pabelick CM, Prakash YS. Temporal aspects of excitation-contraction coupling in airway smooth muscle. J Appl Physiol (1985). 2001 Nov; 91 (5):2266-74
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40. Han YS, Proctor DN, Geiger PC, Sieck GC. Reserve capacity for ATP consumption during isometric contraction in human skeletal muscle fibers. J Appl Physiol (1985). 2001 Feb; 90 (2):657-64
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41. Han Y, Meng T, Murray NR, Fields AP, Brasier AR. Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis. J Biol Chem. 1999 Jan 8; 274(2):939-47.
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42. Sieck GC, Han YS, Prakash YS, Jones KA. Cross-bridge cycling kinetics, actomyosin ATPase activity and myosin heavy chain isoforms in skeletal and smooth respiratory muscles. Comp Biochem Physiol B Biochem Mol Biol. 1998 Mar; 119 (3):435-50
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43. Perkins WJ, Han YS, Sieck GC. Skeletal muscle force and actomyosin ATPase activity reduced by nitric oxide donor. J Appl Physiol (1985). 1997 Oct; 83 (4):1326-32
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